DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pns and Dennd3

DIOPT Version :9

Sequence 1:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	NP_001074535.1	Gene:	Dennd3 / 105841	MGIID:	2146009	Length:	1274	Species:	Mus musculus

Alignment Length:	1273	Identity:	237/1273 - (18%)
Similarity:	391/1273 - (30%)	Gaps:	479/1273 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RAYKSKPLAHYPENVPW--NPFDAH-----------GICMLSLPQGLRFRTQKHCI----EPR-- 149
            |:::.|  ...|...||  :|.|:.           |:.:|:||| |.|   ..|:    ||:
Mouse    80 RSFRKK--REKPRMEPWKSHPGDSKGPDSEDVTIPGGVDLLALPQ-LCF---PGCVCVASEPKED 138

  Fly   150 -FHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNGQQTHSLSRVKQDGPVS 213
             .|....|...|.|.||....:|..:.: ..|             ..||:.....|.:.
Mouse   139 YIHFLVLTDVCGNRTYGVVAQYYRPLHD-EYC-------------FYNGKSHWEPSVIS------ 183

  Fly   214 RSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLICQAPYA------FAAQMFLKNLYRCLPR 272
               .|.|........|...||:..||.|....:...:|:....      |||::.|      :|.
Mouse   184 ---ARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSL------IPS 239

  Fly   273 QPGAGISLESYVYNILYEVMLPQPGKSIRVYLPP-TEPHLPPIALILQRPLLATELPLLDFPLRL 336
            .|...:.|   ::|:          |.::|..|. .:|..|.:.|.|..|||.
Mouse   240 PPPGPLHL---IFNM----------KPLQVVFPSRADPESPIVDLDLHLPLLC------------ 279

  Fly   337 LFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFL 401
             |:   .|.|:|:|||:|.|.:::..|:|:..|.::.||..:.|.|..|.|.:.|||...:..|:
Mouse   280 -FR---PEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFV 340

  Fly   402 DAPVPFVMGLHAECEAAH--KIGSEAT-LCFVDIDKKHIQLPEELPVFPHKVDFMAEIGSVLDKF 463
            .||..|:||.|.:    |  ::..||. |..:|||.
Mouse   341 MAPTSFLMGCHLD----HFEEVRKEADGLVLIDIDH----------------------------- 372

  Fly   464 EIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQMQET 528
                                  |.|:.|.||     |..|....:|  |..|:...:|.|.:|
Mouse   373 ----------------------GSVTCSKSS-----DDNIDIPDVP--LLLAQTFIQRVQSLQ-- 406

  Fly   529 VYTLSGSPGGGVVDYQPLIAHPS-RIDHVPRIADFLRRKGGIRGAGSPVGSPTVSLSSSPVGIYH 592
                               .||. .:.|:....|.  .:|..|
Mouse   407 -------------------LHPDLHLAHLSASTDL--NEGRAR---------------------- 428

  Fly   593 DVDAVDATMPVSTRRAEKQKLSPVDQYYQDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQARDE 657
                         |||.:|.|            |..::.|.|...|.:|...:..:.|.::.
Mouse   429 -------------RRAWQQTL------------NCKIQHITLQLLVGIFREVKNHLNYEHRV--- 465

  Fly   658 WISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKILAMWE--SQPDEQLQLFDQR 720
                      |:...||..:....:.|..:.|::.||.:.:..::....:  ::.|...|..:.|
Mouse   466 ----------FNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDR 520

  Fly   721 VKLLRRRHGENMIAATSYEPCVLSQDSQQGFEKRLNCIDIEVTPPSEILANRAAYFRSFPLLEKG 785
            :        :.|:.:.. .|.|....|::             ..|..|...|...  |.|.|:
Mouse   521 I--------DRMLISPR-RPTVEKMASRK-------------ASPLHITHRRMVV--SMPNLQ-- 559

  Fly   786 VLNQECASRGNSLRRVKNGNKWRAREISLDQKPGSNAINRLSANLTTADVSPALIAQANWTFVER 850
                                     :|||.:.|..|:..|:.........||.|......|::.:
Mouse   560 -------------------------DISLPELPPRNSSLRIMDTSNCRSSSPVLKVTPKSTYMFK 599

  Fly   851 LLKDIKSKTKRMLLEKMGNEAV-----ALGLKGDGIEENTLIASMCDLLEKIWSHGLQN-KQGKS 909
             :.||....:...::....:.|     |:.|.|.|  ::.|:|      ...:..||.: .||:.
Mouse   600 -IPDIHFPLESQCVQAYYTDFVTLLSKAMALLGPG--DSLLLA------RYFYLRGLLHLMQGQL 655

  Fly   910 ALWAHLQAYLEMQ-------------------EARGAGDSSGTEQTPPVSSSPGGKMTIATASPA 955
                 |.|.|:.|                   |:..|.:.:..|:||.:
Mouse   656 -----LSALLDFQNLYKTDIGIFPADLVKRTVESMSASERAQAERTPEL---------------- 699

  Fly   956 LAWNAMRKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFVGLEQLCPLPE---SLEFDVKNVLAMAD 1017
                    |......|....::|.:.:..::.:            ||:   .|...||.|.....
Mouse   700 --------RRLITEVFDKHGEAPKADDAVKNFE------------LPKKHMQLNDFVKRVQESGI 744

  Fly  1018 IKTHIGYTRAWVRLSL--EKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHLLTLNT 1080
            :|..:...|.:..|:.  ||::....||.                |..|.:|.|.....:
Mouse   745 VKDAVIIHRLFDALTFGHEKQIDPETFRD----------------FYTCWKETEAEAQEV----- 788

  Fly  1081 VDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNETQRVPVPKGSLEFIFHYKN 1145
                         .||..::....:....|..||:|         :|.|     |..:.....|.
Mouse   789 -------------SLPALLMEHLDKNECVYKLSSSV---------KTNR-----GVGKIAMTQKR 826

  Fly  1146 LGLLTTMRIGHDNSGPSHKWLVEQV-------------------VMRNEVTGHTYKFPCG----- 1186
            |.|||..|.|:........  :|:|                   |.:.||.....|..|.
Mouse   827 LFLLTEGRPGYVEIATFRN--IEEVKNSTVAFLLLRIPTLKIKTVAKKEVFEANLKSECDLWHLM 889

  Fly  1187 ---RWLGRGVDDDSTERLLVGQRVLTNAKNAELVPGS-------------------DTRTP---P 1226
               .|.|:.:.||..:...| |:.|||....:.|.|:                   ..::|   |
Mouse   890 VKEMWAGKQLADDHKDPQYV-QQALTNVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVP 953

  Fly  1227 RTRSPSVQRQETLAPSEIQHQLGNCVNVLVKWHYKPSR 1264
            :|.|.:::.:...:..|...|   .:.||:   |.|.|
Mouse   954 KTTSETLKHKINPSAGETAPQ---AIEVLL---YTPGR 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	23/86 (27%)
		DENN	243..435	CDD:214823	54/201 (27%)
		dDENN	626..701	CDD:129037	13/74 (18%)
		RUN	<989..1083	CDD:295434	17/98 (17%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	27/134 (20%)
		RUN	1376..1436	CDD:214736
Dennd3	NP_001074535.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..108		7/29 (24%)
		DENN	187..373	CDD:280329	61/275 (22%)
		dDENN	437..499	CDD:129037	13/74 (18%)
		Linker. /evidence=ECO:0000305	520..970		101/601 (17%)
		DUF4401	<615..645	CDD:291049	7/37 (19%)
		WD 1. /evidence=ECO:0000255	975..1013		5/14 (36%)
		WD40	<999..1274	CDD:225201
		WD 2. /evidence=ECO:0000255	1019..1055
		WD40	1021..1274	CDD:295369
		WD40 repeat	1030..1065	CDD:293791
		WD 3. /evidence=ECO:0000255	1059..1099
		WD40 repeat	1072..1118	CDD:293791
		WD 4. /evidence=ECO:0000255	1103..1140
		WD 5. /evidence=ECO:0000255	1146..1181
		WD 6. /evidence=ECO:0000255	1186..1228
		WD40 repeat	1200..1240	CDD:293791
		WD 7. /evidence=ECO:0000255	1234..1273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810