DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pns and Dennd5b

DIOPT Version :9

Sequence 1:NP_647620.1 Gene:pns / 38178 FlyBaseID:FBgn0035229 Length:1449 Species:Drosophila melanogaster
Sequence 2:XP_038964850.1 Gene:Dennd5b / 100365679 RGDID:2318606 Length:1302 Species:Rattus norvegicus


Alignment Length:1510 Identity:598/1510 - (39%)
Similarity:816/1510 - (54%) Gaps:292/1510 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 SGSGNGSGNGSGPNIQVAPSSTLVQSPTSPGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDL 83
            ||||...|.|||                                  :.|...|||.|||:||:|.
  Rat     2 SGSGAAPGPGSG----------------------------------SSPAACRFAHYFVLCGIDA 32

  Fly    84 DTGLEPDRFA----------------------------GDNLHCSPLDRAYKSKPLAHYPENVPW 120
            |:|||||..|                            |:|...|||.|.:|||.|||||:|:.|
  Rat    33 DSGLEPDELAVLYQWLEADRHGKSQDAANTTSGRNSLRGENFDQSPLRRTFKSKVLAHYPQNIEW 97

  Fly   121 NPFDAHGICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHT 185
            ||||...:.||.:|:||.||||....:|:||||..|||||.|.|||.|.||||:.::.||.|:.|
  Rat    98 NPFDQDAVNMLCMPKGLSFRTQADNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQT 162

  Fly   186 LQSMFITE------LSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSY--YDINKDKLY 242
            |..|...|      .|:.....||:....:|..:..|            ..|.|  ||||:|.||
  Rat   163 LYQMHNAEQYSSVYASSSCSMDSLASSIDEGDATSLL------------KLQRYNSYDINRDTLY 215

  Fly   243 VAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIRVYLPPT 307
            |:|||.||...|:..|.:.||..|::.:..|....:.||||::||||||.||.||:|::.| ...
  Rat   216 VSKSICLITPLPFMQACRKFLLQLHKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFY-GVY 279

  Fly   308 EPHLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIV 372
            ||      :|.||| ...||||.|:|||...:.||:|.::|:.||||||.|:||.|.||||||.|
  Rat   280 EP------VICQRP-GPNELPLSDYPLREACELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTV 337

  Fly   373 GECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEAAHK----IGSEATLCFVDID 433
            .|.||:|||||.|.|||.|||||:|.||||||||::|||.:: |...:    :..||.|||||||
  Rat   338 AEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSK-EGTDRSKLELPQEANLCFVDID 401

  Fly   434 KKHIQLPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGG 498
            ...|:||||.|.||:||||:.|:..||.:|.|.                                
  Rat   402 NHFIELPEEFPQFPNKVDFIQELSEVLLQFGIP-------------------------------- 434

  Fly   499 VDAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVP----RI 559
                      |.|......|..:.:.|.             :.|    :|:..:..:||    .:
  Rat   435 ----------PEGSLHCSESATKLKNMV-------------LKD----LANDKKNGNVPTNNVSV 472

  Fly   560 ADFLRRKGGIRGAGSPVGSPTVS---LSSSPVGIYHDVDAVDATMPVSTRRAEKQ-KLSPVDQYY 620
            .:.|:            ||.|::   ..:...|:  .|..:|  .|.|....||. ||...:...
  Rat   473 YELLK------------GSETIARLQALAKRTGV--TVGKID--FPASLSEKEKDLKLQCEEADL 521

  Fly   621 QDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFL 685
            :|.::|..:||:|.|||..||..||.|||...|..:.|:::||.:|||||:||||||||.:..||
  Rat   522 RDSQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTSREQMQNFDKASFLSDQPEPYLPFL 586

  Fly   686 SRFLESQMFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATS-YEPCVLSQDSQQ 749
            |||:|:|||||.|||||::.|| :.|..|::||.|::.:|..:.......|| |:.|...:::.|
  Rat   587 SRFIETQMFATFIDNKIMSQWE-EKDPLLRVFDSRIEKMRLYNVRAPTLRTSIYQKCSSLKEAAQ 650

  Fly   750 GFEKRLNCIDIEVTPPS--EILANRAAYFRS-FPLLEKGVL------NQECASRGNSLRRVKNGN 805
            ..|:||..:|.....|.  ::...:..|.:. ||.|:..||      |....||..:.:|.|...
  Rat   651 SIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPANNNRWVSRSTTAQRRKERL 715

  Fly   806 KWRAREISLD---QKPGSNAINRLSANL---TTADVSPALIAQANWTFVERLLKDIKSKTKRMLL 864
            :..|..|.||   ::........|..||   ..:|:|||:|||.||.|||.|||:.:.||||||:
  Rat   716 RQNAEHIGLDSDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNWKFVEGLLKECRMKTKRMLV 780

  Fly   865 EKMGNEAVALGLKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQEAR 925
            ||||:|||.|| .|:    |:||||||||:|||||:||||||..||||||||:||..:.:.:|  
  Rat   781 EKMGHEAVELG-HGEANITGLEENTLIASLCDLLERIWSHGLLVKQGKSALWSHLIQFQDREE-- 842

  Fly   926 GAGDSSGTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPS--PNRSRSRD 988
                                                  :.::|:      |||.:  |.|.:|..
  Rat   843 --------------------------------------KQEHLT------DSPVALGPERRKSDS 863

  Fly   989 RNKFVGLEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLR 1053
                 |: .|..|..||..|:::|..|.:|||.:|..|||:||||||||||:|.:.|||::.|.:
  Rat   864 -----GV-MLPTLRVSLIQDMRHVQNMTEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTK 922

  Fly  1054 SLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWI 1118
            .||||.||||||||:||||||||:||.||||.||:::.|..:|||.||.|.:|..:...:||.||
  Rat   923 KLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWI 987

  Fly  1119 MVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKF 1183
            .|||.:.:|..:.:||..||..|..:|||.|||::|||||||...||||:.|::|||:|||||:|
  Rat   988 CVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRF 1052

  Fly  1184 PCGRWLGRGVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSVQRQETLA-------- 1240
            |||||||:||||.|.||:|:|: ::|:|.:.:|  |...||||:.:||:..|:.::.        
  Rat  1053 PCGRWLGKGVDDGSLERILIGE-LMTSASDEDL--GKQCRTPPQQKSPTTTRRLSITSLTGKPAK 1114

  Fly  1241 --PSEIQHQLGNCVNVLVKWHYKPSRDRDVGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNL 1303
              ..:||..:|..||.:||..:||.::|  |:||.||||::|||..|||||..||:|||.|.:|:
  Rat  1115 PNAGQIQEGIGEAVNNIVKHFHKPEKER--GSLTVLLCGENGLVAALEQVFHHGFKSARIFHKNV 1177

  Fly  1304 YIWDYFTKIKELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREISSIWRLYVQLMDEINGT 1368
            :|||:..|....||...|: |::....|              :|:...    :.:...::.:| |
  Rat  1178 FIWDFVEKAVAYFESTDQI-LDNEDDML--------------IQKPSC----KTFCHYVNAVN-T 1222

  Fly  1369 A---LGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDD 1430
            |   :|||||||:|:||..|:|||.:.|..:|.......||||.:.||....:..||:||:.:.|
  Rat  1223 APRNIGKDGKFQILVCLGTRDHLLPQWIPLLAECPAITRMYEENALLRDHMTVNSLIRILQTIQD 1287

  Fly  1431 CHIVLENSITQGIRI 1445
            ..||||.|:.:|:.:
  Rat  1288 FTIVLEGSLIKGVDV 1302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pnsNP_647620.1 uDENN 70..171 CDD:214824 60/128 (47%)
DENN 243..435 CDD:214823 102/195 (52%)
dDENN 626..701 CDD:129037 44/74 (59%)
RUN <989..1083 CDD:295434 53/93 (57%)
PLAT_RAB6IP1 1095..1203 CDD:238855 61/107 (57%)
RUN 1376..1436 CDD:214736 24/59 (41%)
Dennd5bXP_038964850.1 uDENN 19..148 CDD:214824 60/128 (47%)
DENN 215..403 CDD:396629 103/196 (53%)
dDENN 527..602 CDD:129037 44/74 (59%)
RUN 808..952 CDD:397055 83/195 (43%)
PLAT_RAB6IP1 964..1072 CDD:238855 61/107 (57%)
RUN 1155..1292 CDD:413440 55/156 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 143 1.000 Domainoid score I4535
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H44911
Inparanoid 1 1.050 944 1.000 Inparanoid score I324
OMA 1 1.010 - - QHG52593
OrthoDB 1 1.010 - - D35195at33208
OrthoFinder 1 1.000 - - FOG0003741
OrthoInspector 1 1.000 - - otm44664
orthoMCL 1 0.900 - - OOG6_104889
Panther 1 1.100 - - LDO PTHR46070
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2599
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.980

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