Protein Alignment pns and dennd5b

DIOPT Version :10

• Sequence 1: NP_647620.1
• Gene: pns / 38178
• FlyBaseID: FBgn0035229
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_031753574.1
• Gene: dennd5b / 100216203
• XenbaseID: XB-GENE-1009600
• Length: 1321
• Species: Xenopus tropicalis
• Alignment Length: 1474
• Identity: 581/1474 - (39%)
• Similarity: 814/1474 - (55%)
• Gaps: 264/1474 - (17%)

  Fly    71 RFADYFVICGLDLDTGLEPDRFA-----------------GDNLHCSPLDRAYKSKPLAHYPENV 118
            |.|.||||||.|.|:|||||..|                 |:|...|||.|.:|||.|||||:||
 Frog    13 RLAHYFVICGTDADSGLEPDELAVLYQWLEADRHGKGHDTGENFEQSPLRRTFKSKVLAHYPQNV 77

  Fly   119 PWNPFDAHGICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAI 183
            .|:|||...:.||.:|:||.||||....:|.||||..|||||.|.|||.|.||||:.:|.||.|:
 Frog    78 EWSPFDQDAVNMLCMPKGLSFRTQADDRDPEFHSFIITREDGSRTYGFVLTFYEEVTSRQICAAM 142

  Fly   184 HTLQSMFITELSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQS-------AQSY--YDINKD 239
            .||..|...|.||  ..::.|....|           .:|..|.:|       :|.|  |||:||
 Frog   143 QTLYQMHNAEQSN--SVYASSSCSMD-----------SLASSADESDDASLAKSQRYNSYDISKD 194

  Fly   240 KLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIRVYL 304
            .|||:|.|.||...|:..:.:.||..||:.:.......:.||||::||||||.||.||:|::.|.
 Frog   195 TLYVSKCICLITPLPFMQSCRKFLTQLYKAVTSPQPPPLPLESYIHNILYEVPLPPPGRSLKFYG 259

  Fly   305 PPTEPHLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRL 369
            ...       |::.||| ..:||||.|:|||..|:.||:|.::||.||||||.|:||.|.|||||
 Frog   260 VYE-------AIVCQRP-GPSELPLSDYPLRETFELLGLENLVQLFTCVLLEMQILLYSQDYQRL 316

  Fly   370 MIVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEAAHK----IGSEATLCFV 430
            |.|.|.||||||||.|.|||.|||||:|.||||||||::|||.:: |...:    :..||.||||
 Frog   317 MTVAEGITSLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSK-EGTDRSKLELPQEANLCFV 380

  Fly   431 DIDKKHIQLPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSG 495
            |||...|:||||.|.||:|::|:.||..||.::                       |:...|:..
 Frog   381 DIDNHFIELPEEFPQFPNKLEFIQEISEVLLQY-----------------------GIPPEGNLH 422

  Fly   496 SGGVDAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIA 560
            .......:.|..|...:...:..            .|||:   .:..|:.|..:    :.:.|:.
 Frog   423 CSESATKLKSLALDDWVNDKKNG------------NLSGN---NINMYELLKGN----ETIARLQ 468

  Fly   561 DFLRRKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPVDQYYQDLRI 625
            ...:|.|        :....::| ::|:     |||.|           :||:...::..||.::
 Frog   469 ALTKRTG--------ITMDKINL-AAPL-----VDAED-----------EQKVQCAEKELQDYKL 508

  Fly   626 NNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLE 690
            |..:||:|.|||..||..||.|||......:.|::|||.:|||||:||||||||.:..|||||:|
 Frog   509 NVQLREVFANRFTQMFSDYEAFVIQSAHDMESWLNNREQMQNFDKASFLSDQPEPYLPFLSRFIE 573

  Fly   691 SQMFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGE-NMIAATSYEPCVLSQDSQQGFEKR 754
            :|||||.|||||:::|: :.:..|::||.|::.||..:|. ..:.:::|:.|...:::.|..|:|
 Frog   574 TQMFATFIDNKIMSLWD-EKEPLLRVFDSRIQKLRLYNGRAPALRSSNYKKCTALKEAAQAIEQR 637

  Fly   755 LNCIDIEVTPPS--EILANRAAYFRS-FPLLEKGVL------NQECASRGNSLRRVKNGNKWRAR 810
            |..||.....|.  ::...:..|.:. ||.|:..||      |....||..:.:|.|:..:..:.
 Frog   638 LTKIDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLMTGPTNNNRWVSRSATAQRRKDKLRQHSE 702

  Fly   811 EISLD---QKPGSNAINRLSA----------------------------------------NLTT 832
            .:.||   ::|....:.|.::                                        ....
 Frog   703 HLGLDNDLREPSEEIVIRQNSMAFWEWDQGSPPPARPPKKSYSECCLKYMQEARSLGKTVRQPKL 767

  Fly   833 ADVSPALIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALGLKGD----GIEENTLIASMCDL 893
            :|:|||:|||.|..|||.|||:.:.||||||:||||:|||.|| .|:    |:||||||||:|||
 Frog   768 SDLSPAVIAQTNSKFVEGLLKECRMKTKRMLVEKMGHEAVELG-HGEANITGLEENTLIASLCDL 831

  Fly   894 LEKIWSHGLQNKQGKSALWAHLQAYLEMQEARGAGDSSGTEQTPPVSSSPGGKMTIATASPALAW 958
            ||:||||||..||||||||:||..:.|.:|.        .|:|....::||
 Frog   832 LERIWSHGLLVKQGKSALWSHLVQFQEREER--------LERTAESPTAPG-------------- 874

  Fly   959 NAMRKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFVGLEQLCPLPESLEFDVKNVLAMADIKTHIG 1023
                                  |:|.:|.     .|: .|..|..||..|::::..:::|||.:|
 Frog   875 ----------------------PDRRKSD-----TGV-SLPSLRVSLIQDMRHIQNLSEIKTDVG 911

  Fly  1024 YTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTN 1088
            ..|.|:||||||||||:|.:.||::::|.|.||||.|||||||||||||||||:||.||||.||:
 Frog   912 RARGWIRLSLEKKLLSQHLKQLLTNQSLTRKLYKRYAFLRCEEEKEQFLYHLLSLNAVDYFCFTS 976

  Fly  1089 IYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMR 1153
            ::.|..:||||||.|.:|..:..|:||.||.|||.:.:|..:.:||..||..|..:|||.:||::
 Frog   977 VFTTIMVPYRVVIIPIKKLSNAITTSNPWICVSGELGDTGVMQIPKNLLEMTFESQNLGKMTTVQ 1041

  Fly  1154 IGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPCGRWLGRGVDDDSTERLLVGQRVLTNAKNAELVP 1218
            :||||||...||||:.||:|:|:||||||||||||||:||||.|.||:|:|: ::|...:.:|
 Frog  1042 LGHDNSGLLAKWLVDCVVVRSEITGHTYKFPCGRWLGKGVDDGSLERVLIGE-LITPTSDDDL-- 1103

  Fly  1219 GSDTRTPPRTRSPSVQRQ--------ETLAPS--EIQHQLGNCVNVLVKWHYKPSRDRDVGTLTN 1273
            |..:||||:.:||:|.|:        :.:.|:  :||..:|..:|.:||..:||.::|  |:||.
 Frog  1104 GKQSRTPPQQKSPTVARRLSITSLTGKNIKPNAGQIQEGIGEAINNIVKHFHKPEKER--GSLTV 1166

  Fly  1274 LLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKIKELFEHNLQMELEDSSSSLDSSFSNG 1338
            ||||:.|||..|||:|..||:|||.|.::::|||:..|....||...|:               |
 Frog  1167 LLCGESGLVSALEQLFHHGFKSARIFQKSVFIWDFIEKAVAYFETTDQI---------------G 1216

  Fly  1339 SGSGGNSLQRREISSIWRLYVQLMDEINGTA--LGKDGKFQLLICLSLREHLLTRLIKPMALTKV 1401
            .|...:.:.|    |..:.:...::.|....  :|||||||||:||..|:|||...|..:|....
 Frog  1217 DGEADHLIPR----SSCKTFCHYVNAIVAAPRHIGKDGKFQLLVCLGARDHLLALWIPLLAECPA 1277

  Fly  1402 THEMYEEESFLRRRNLLTFLIQILEPLDDCHIVLENSITQGIRI 1445
            ...||||.:.||....:..||::|:.|.|.:||||.|:.:|:.:
 Frog  1278 ITRMYEENALLRDPMTVNSLIRVLQTLQDFNIVLEGSLVKGVDV 1321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	60/116 (52%)
		DENN	243..435	CDD:214823	101/195 (52%)
		dDENN	626..701	CDD:129037	44/74 (59%)
		RUN1_DENND5	839..1091	CDD:439039	121/255 (47%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	62/107 (58%)
		RUN2_DENND5	1243..1440	CDD:439040	74/198 (37%)
dennd5b	XP_031753574.1	uDENN	11..130	CDD:214824	60/116 (52%)
		DENN	197..385	CDD:460461	102/196 (52%)
		dDENN	509..584	CDD:129037	44/74 (59%)
		RUN	774..979	CDD:459241	121/255 (47%)
		PLAT_RAB6IP1	983..1091	CDD:238855	62/107 (58%)
		RUN2_DENND5B	1138..1316	CDD:439055	74/198 (37%)