Protein Alignment pns and dennd5a

DIOPT Version :10

• Sequence 1: NP_647620.1
• Gene: pns / 38178
• FlyBaseID: FBgn0035229
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_001121468.1
• Gene: dennd5a / 100158564
• XenbaseID: XB-GENE-970289
• Length: 1285
• Species: Xenopus tropicalis
• Alignment Length: 1500
• Identity: 578/1500 - (38%)
• Similarity: 806/1500 - (53%)
• Gaps: 295/1500 - (19%)

  Fly    25 SGNGSGPNIQVAPSSTLVQSPTSPGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDLDTGLEP 89
            ||.|.|             |.|:||                     ||||||||||||..|||||
 Frog     2 SGGGGG-------------SSTAPG---------------------RFADYFVICGLDTGTGLEP 32

  Fly    90 DRFA------------------------GDNLHCSPLDRAYKSKPLAHYPENVPWNPFDAHGICM 130
            |..:                        |:|...:||.|.:|||.||.|||||.||.||...:.|
 Frog    33 DELSALCEYIQASKARDGAGRFLPSAAEGENFEQTPLRRTFKSKVLARYPENVEWNAFDQDAVGM 97

  Fly   131 LSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSM------ 189
            |.:|:||.|:||....||::|:|..|||||.|.:||||.|:||:.::.||.|:.||..|
 Frog    98 LCMPKGLAFKTQADPKEPQYHAFIITREDGSRTFGFSLTFFEEVTSKQICSAMQTLYHMHNAEYD 162

  Fly   190 -FITELSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSA----QSY--YDINKDKLYVAKSI 247
             ..|..|||                |..|      |:...|:    |.:  |||.:|.|||:|.|
 Frog   163 IIHTSASNG----------------RDCP------GECTDSSITKLQRFNSYDITRDTLYVSKCI 205

  Fly   248 TLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIR---VYLPPTEP 309
            .||....:..|.:..|:.|::.:.......:.||||:|||||||.||..|:|::   ||.|
 Frog   206 CLIAPMSFMTACKKVLEQLHQAVTSPQPPPLPLESYIYNILYEVPLPPAGRSLKFNGVYGP---- 266

  Fly   310 HLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGE 374
                  ::.||| ...||||.|||.:.:|:.||||.|:||.||.|||.|:||.|..|||||.|.|
 Frog   267 ------IVCQRP-STNELPLFDFPAQEVFELLGVENVVQLFTCALLEFQILLYSQHYQRLMTVAE 324

  Fly   375 CITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHA---ECEAAHKIGSEATLCFVDIDKKH 436
            .||.|:|||.|.|||.|||||:|.||||||||::||||:   :..:..::..||.|||||||...
 Frog   325 TITGLMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHF 389

  Fly   437 IQLPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDA 501
            |:|||:||.||:|::|:.|:..:|..|.|..:.:...|
 Frog   390 IELPEDLPQFPNKLEFIQEVSEILLAFGIPPEGNLHCS--------------------------- 427

  Fly   502 MISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIADFLRRK 566
              .|.:....|:||....::...      .|:|||   :..|:.|    ...:.:.|:...::|.
 Frog   428 --ESISKLRNLKAADLVSDKRNG------NLAGSP---LNSYELL----KENETIARLQALVKRT 477

  Fly   567 GGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPVDQYYQDLR---INNS 628
            |             |||...          |:.....|:::..|   :..|:  ::||   :|..
 Frog   478 G-------------VSLEKQ----------VEVREESSSKKDGK---AHCDE--EELRMHQLNIQ 514

  Fly   629 VREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQM 693
            |||:|.|||..||..||.|||.|:|.::.|.:|||.:|||||:||||||||.:..|||||||:||
 Frog   515 VREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQM 579

  Fly   694 FATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATS-YEPCVLSQDSQQGFEKRLNC 757
            ||:.|||||:...:...|..|::||.||..:|:.:.......|| |:.|...:::.:..|:||:.
 Frog   580 FASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRQLNVRTPTLRTSMYQKCTAIEEAVKAIEQRLSK 644

  Fly   758 IDIEVTPPS--EILANRAAYFRS-FPLLEKGVLNQECASRGNSLR------RVKNGNKWRAREIS 813
            ||.....|.  ::...:..|... ||.|:..||:...|:...:.|      |.|:..|..:..:.
 Frog   645 IDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPATNKWTKRNAPAQWRRKDRQKQHSEHLR 709

  Fly   814 LDQKPGSNAINRLSANLTT-------ADVSPALIAQANWTFVERLLKDIKSKTKRMLLEKMGNEA 871
            ||.......|.. :.|:::       :::||::|||.||.|||.|||:.::||||||:||||.||
 Frog   710 LDNDQREKYIQE-ARNMSSGIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREA 773

  Fly   872 VALGLKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQEARGAGDSSG 932
            |.|| .|:    |:|||.||||:|||||:|||||||.||||||||:||..|.:.:.....|...|
 Frog   774 VELG-HGEVSITGVEENALIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDSRRRATWGSLGG 837

  Fly   933 TEQTPPVSSSPGGKMTIATASPALAWNAMRKRMD-YLSTFQTDFDSPPSPNRSRSRDRNKFVGLE 996
            |:                     |..:..|::.| :|..:
 Frog   838 TD---------------------LVLDCERRKSDPFLVMY------------------------- 856

  Fly   997 QLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAF 1061
               ||..||..|::::..:.:|||.:|..|||||||:||||||||.:.||.|..|.:.||||.||
 Frog   857 ---PLKISLVQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLLDHDLSKKLYKRYAF 918

  Fly  1062 LRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNE 1126
            |||::||||||||||:.|.||||.|||::.|..:||.::|.||:|.|....::|.||.:||.:.|
 Frog   919 LRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTIMIPYHILIVPSKKLGGSMFTANPWICISGELGE 983

  Fly  1127 TQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPCGRWLGR 1191
            |..:.||:..||..:..:|||.|||::|||||||...|||||.|::|||:||||||||||||||:
 Frog   984 TGVLQVPRNILEMTYECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGK 1048

  Fly  1192 GVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPS-VQRQETLAPS--------EIQHQ 1247
            |:||.|.||:|||. :||::.:.|..|   .||||...||| ::|...::|:        :||..
 Frog  1049 GMDDGSLERVLVGD-LLTSSTDTEEKP---CRTPPLQHSPSMIRRLVAISPNSRPKLNTGQIQEA 1109

  Fly  1248 LGNCVNVLVKWHYKPSRDRDVGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKI 1312
            :|..||.:||..:||.::|  |:||.||||::|||..|||||..|.||.|.| ::::|||:..|.
 Frog  1110 IGEAVNGIVKHFHKPEKER--GSLTLLLCGENGLVSALEQVFQHGIRSPRLF-KSIFIWDFLEKA 1171

  Fly  1313 KELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREISSIWRLYVQLMDEINGTA--LGKDGK 1375
            :..:|   .:|:.:.....|             .|:|.     |.:.:.::.||...  :|||||
 Frog  1172 QAYYE---SLEVNELVPEED-------------WQKRA-----RNFSRFINAINNNPRNIGKDGK 1215

  Fly  1376 FQLLICLSLREHLLTRLIKPMALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIVLENSIT 1440
            ||:.:||..|:|.|...|..:|...:..:||||.:.::...|:..||::|:.|.:.:|.||:|:.
 Frog  1216 FQMFVCLGARDHHLHHWIALLADCPIIAQMYEETALIKDHTLVNSLIRVLQTLQEFNITLESSLI 1280

  Fly  1441 QGIRI 1445
            :||.|
 Frog  1281 KGINI 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	59/124 (48%)
		DENN	243..435	CDD:214823	97/197 (49%)
		dDENN	626..701	CDD:129037	47/74 (64%)
		RUN1_DENND5	839..1091	CDD:439039	120/256 (47%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	60/107 (56%)
		RUN2_DENND5	1243..1440	CDD:439040	69/198 (35%)
dennd5a	NP_001121468.1	uDENN	12..137	CDD:214824	61/145 (42%)
		DENN	200..388	CDD:460461	98/198 (49%)
		dDENN	512..587	CDD:129037	47/74 (64%)
		RUN1_DENND5A	741..948	CDD:439052	120/256 (47%)
		PLAT_RAB6IP1	952..1060	CDD:238855	60/107 (56%)
		RUN2_DENND5A	1105..1280	CDD:439054	69/198 (35%)