DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12091 and PPM1F

DIOPT Version :9

Sequence 1:	NP_001261261.1	Gene:	CG12091 / 38177	FlyBaseID:	FBgn0035228	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_055449.1	Gene:	PPM1F / 9647	HGNCID:	19388	Length:	454	Species:	Homo sapiens

Alignment Length:	280	Identity:	62/280 - (22%)
Similarity:	98/280 - (35%)	Gaps:	106/280 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 VMGVADGVGGWRSY--------GIDPGEFSSFLMRTCERLVQCSHFN-------PQRPVNLLAYS 141
            :.|::|.|.  |:|        |:|...:::..:          |.|       |..|...|..:
Human   182 LFGLSDPVN--RAYFAVFDGHGGVDAARYAAVHV----------HTNAARQPELPTDPEGALREA 234

  Fly   142 YCE-----LMEQKKPILGSST--ACVLILNRETSTVHTANIGDSGFVVVREGQVV-----HKSEE 194
            :..     |.:.|:..|.|.|  .|.||..   :|:|.|.:|||..::|::||||     |:.|.
Human   235 FRRTDQMFLRKAKRERLQSGTTGVCALIAG---ATLHVAWLGDSQVILVQQGQVVKLMEPHRPER 296

  Fly   195 QQHYFNTPFQLSLPPPG-----------HGPNVLSDSPESADTMSFPVRDG-------------D 235
            |..      :..:...|           :|  .|:.|....|....|...|             |
Human   297 QDE------KARIEALGGFVSHMDCWRVNG--TLAVSRAIGDVFQKPYVSGEADAASRALTGSED 353

  Fly   236 VILIATDGVFDNVPED----LMLQVLSEVEGERDPVKLQMTANSLALMARTLSLNSEFLSPFALS 296
            .:|:|.||.||.||..    |:...|:..:|....|..::.|                      :
Human   354 YLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVA----------------------A 396

  Fly   297 ARRNNIQARGGKPDDITVVL 316
            ||..      |..|:|||::
Human   397 ARER------GSHDNITVMV 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12091	NP_001261261.1	PP2Cc	76..316	CDD:294085	62/278 (22%)
PPM1F	NP_055449.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PP2C	155..406	CDD:278884	59/274 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900