DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12091 and PTC7

DIOPT Version :9

Sequence 1:	NP_001261261.1	Gene:	CG12091 / 38177	FlyBaseID:	FBgn0035228	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_011943.2	Gene:	PTC7 / 856475	SGDID:	S000001118	Length:	343	Species:	Saccharomyces cerevisiae

Alignment Length:	332	Identity:	93/332 - (28%)
Similarity:	156/332 - (46%)	Gaps:	32/332 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SRAISRALRSSFSTLLETATGGGSGAAAKGATKSGATPGS-------SGAPRPRFVSVVCGFAKD 66
            |:.||.:.|:.:|:   ..:|..|..:...|..||:..|.       :..|:.| ..::....||
Yeast    22 SQIISFSKRTFYSS---AKSGYQSNNSHGDAYSSGSQSGPFTYKTAVAFQPKDR-DDLIYQKLKD 82

  Fly    67 NLRHKYKPGKYGEDSWFKASTASADVM-GVADGVGGWRSYGIDPGEFSSFLMRTCERLVQCSHFN 130
            ::|     ...|||::|..|....|:. |||||||||..:|.|....|..|.:..:.:......|
Yeast    83 SIR-----SPTGEDNYFVTSNNVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAEN 142

  Fly   131 PQR-----PVNLLAYSYCELMEQKKPILGSSTACVLILNRETSTVHTANIGDSGFVVVREGQVVH 190
            ..:     |..::..:|.::.::|...:|.:||.|... .....:..||:|||...|.|:.::|.
Yeast   143 SSKETLLTPKKIIGAAYAKIRDEKVVKVGGTTAIVAHF-PSNGKLEVANLGDSWCGVFRDSKLVF 206

  Fly   191 KSEEQQHYFNTPFQLSLPP-------PGHGPNVLSDSPESADTMSFPVRDGDVILIATDGVFDNV 248
            :::.|...||.|:|||:.|       ...|...:.::|..||..||.::..|:|::|||||.||:
Yeast   207 QTKFQTVGFNAPYQLSIIPEEMLKEAERRGSKYILNTPRDADEYSFQLKKKDIIILATDGVTDNI 271

  Fly   249 PEDLMLQVLSEVEGERDPVKLQMTANSLALMARTLSLNSEFLSPFALS-ARRNNIQARGGKPDDI 312
            ..| .:::..:....|...:||:.:........:||.:..:.|.||.. ::.......|||.|||
Yeast   272 ATD-DIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDPNYPSVFAQEISKLTGKNYSGGKEDDI 335

  Fly   313 TVVLATV 319
            |||:..|
Yeast   336 TVVVVRV 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12091	NP_001261261.1	PP2Cc	76..316	CDD:294085	75/253 (30%)
PTC7	NP_011943.2	PTC1	50..343	CDD:223704	85/301 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343189
Domainoid	1	1.000	103	1.000	Domainoid score	I1493
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6100
Inparanoid	1	1.050	110	1.000	Inparanoid score	I1383
Isobase	1	0.950	-	0	Normalized mean entropy	S1764
OMA	1	1.010	-	-		QHG56397
OrthoFinder	1	1.000	-	-		FOG0002449
OrthoInspector	1	1.000	-	-		otm46545
orthoMCL	1	0.900	-	-		OOG6_100742
Panther	1	1.100	-	-	LDO	PTHR12320
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R127
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740