DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12091 and PPM1K

DIOPT Version :9

Sequence 1:	NP_001261261.1	Gene:	CG12091 / 38177	FlyBaseID:	FBgn0035228	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_689755.3	Gene:	PPM1K / 152926	HGNCID:	25415	Length:	372	Species:	Homo sapiens

Alignment Length:	319	Identity:	62/319 - (19%)
Similarity:	108/319 - (33%)	Gaps:	111/319 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GAPRPR--FVSVVC----GFAKDNLRHKYKPGKYGEDSW-FKASTASADVMGVADGVGGWRSYGI 107
            |.|.|:  ..:|.|    |..|:|           ||.: |...|.......|.||.||..:
Human    84 GKPIPKISLENVGCASQIGKRKEN-----------EDRFDFAQLTDEVLYFAVYDGHGGPAA--- 134

  Fly   108 DPGEFSSFLMRTC-------ERLVQCSHFNPQRPVNLLAYSYCEL---------MEQKKPILGSS 156
              .:|....|..|       |:.::          .||..::.|:         :.....:|.|.
Human   135 --ADFCHTHMEKCIMDLLPKEKNLE----------TLLTLAFLEIDKAFSSHARLSADATLLTSG 187

  Fly   157 TACVLILNRETSTVHTANIGDSGFVVVREGQVVHKSEEQQHYFNTPFQLSLPPPGHGPNVLSDSP 221
            |...:.|.|:...:..|::|||..::.|:|:              |.:|:          :..:|
Human   188 TTATVALLRDGIELVVASVGDSRAILCRKGK--------------PMKLT----------IDHTP 228

  Fly   222 ESAD---------------TMSFPVRDGDVILIATDGVFDNVPEDLMLQ---VLSEVEGERDPVK 268
            |..|               ::..|..:|.:.:..:.|       ||.|:   |::|.|.:|  :|
Human   229 ERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMTRSIG-------DLDLKTSGVIAEPETKR--IK 284

  Fly   269 LQMTANSLALMAR---TLSLNSEFLSPFALSARRNNIQARG--------GKPDDITVVL 316
            |....:|..::..   ...:||:.:..|.......|..|..        |..|:.|.|:
Human   285 LHHADDSFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVV 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12091	NP_001261261.1	PP2Cc	76..316	CDD:294085	53/285 (19%)
PPM1K	NP_689755.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..55
PPM1K	NP_689755.3	PP2Cc	95..346	CDD:238083	59/308 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900