DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iml1 and DEPDC5

DIOPT Version :9

Sequence 1:	NP_728621.1	Gene:	Iml1 / 38176	FlyBaseID:	FBgn0035227	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	NP_001229825.1	Gene:	DEPDC5 / 9681	HGNCID:	18423	Length:	1603	Species:	Homo sapiens

Alignment Length:	1720	Identity:	602/1720 - (35%)
Similarity:	867/1720 - (50%)	Gaps:	326/1720 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLYKLNTHTRGCNKSYDADLVMNLKDHPNANVGDVVEIYAPDEENGTHLLLQITEFNGSCGRDVI 66
            |:|||..|.:|...| |.:||:|.|..|:..:||:|||..|::|. :.||||:........::.|
Human     5 KVYKLVIHKKGFGGS-DDELVVNPKVFPHIKLGDIVEIAHPNDEY-SPLLLQVKSLKEDLQKETI 67

  Fly    67 SIESGIANAFKMRPYSNVVMRIVKPADVALDSIEITFKDQYMGRSEMWRLKTYLTDTCVYVNKKI 131
            |::..:...|::|||.:|.:.:|.|.||.||.:|:||||||:||.:|||||..|..||.|:.:|:
Human    68 SVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKV 132

  Fly   132 DYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGDLYFEKA 196
            ::  ..||.|..|:|.:.|:|..|.|:|||::||||:::|||:|:|||.|||||||:||||||||
Human   133 EF--AGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKA 195

  Fly   197 VNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQQDYKGRFYEDFYRVAIQ 261
            |||||.:||.||::.:|:||||:||||||||.|||:|||||..|..::||:|||||||||:|.:|
Human   196 VNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQ 260

  Fly   262 NERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPATNSSATQGNFLEVLNISLNTFEKHYL 326
            |||.::|.::|..::|||..|...| |..:.|.  .|...||::.|||:||.:|:|.|.|:|||:
Human   261 NERREEWTSLLVTIKKLFIQYPVLV-RLEQAEG--FPQGDNSTSAQGNYLEAINLSFNVFDKHYI 322

  Fly   327 DRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKDT 391
            :|.||||||:|||||||||||.|||.|..:||||:||||:|.||||:||||||||||.|.||:..
Human   323 NRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSA 387

  Fly   392 TLTS--ADDYSLPHWINLSFYSTNKKIVYSSFIPRIKLPLFGSQLTLHDGVGDGEGEENERHFLS 454
            ...|  .|||::|||||.|||::..::..:||.|||||.  |.:..       .|..:|.|. .|
Human   388 PRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLA--GKKPA-------SEKAKNGRD-TS 442

  Fly   455 CNQSEYKHNSL---FDYDAYDEQIFQ-PLPAQSTC-SLQRVVRAKK------------TSVPSLE 502
            ....:...|:|   .||||||.|:|: |.|:::.| :..|.||.::            :|.|||.
Human   443 LGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLP 507

  Fly   503 TYAYRNNDWENLTPTQIPAMRRKMSDPDIHHGTSA-MLAALQPDTTNLSESLASEKNSRRTIV-- 564
            :         ...||:  .:|.:.|| |...|.|| :|....|.......|.:....|.|.::
Human   508 S---------RTLPTE--EVRSQASD-DSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLEN 560

  Fly   565 --------SIAP------------IVRPG-----RALINPFDPSQVTIKLTSNRRRWTHIFPKGP 604
                    |.||            .||||     |||||||.||::.:|||||||||.|.||.||
Human   561 MMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGP 625

  Fly   605 TGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSNNNNDQEDYGCENGE--QYDRVSSHSLLNKSDSS 667
            :|..||.||         |..|.  :.:.|.:...|......|..|  .::....||...:....
Human   626 SGEAIQIHH---------QTRQN--MAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDG 679

  Fly   668 QSFV--MGDEPIDF-FKRRQNSPMNPQPANVPNLTATQAKSYLWGATGEQEWTPAITTVKHLRPI 729
            .||:  .|.|.:.. ......:.|||:..|..:|                  ..:::|
Human   680 MSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSL------------------EDSVST------- 719

  Fly   730 VEGEHHHLGSLEALRALDPPPDAEAGGGRGKII------IGVDWKSLTIPACLPITTDYFPDKRS 788
                     |.:.:..|..||          ::      :||||||||.|||||:|||||||::.
Human   720 ---------SPDPILTLSAPP----------VVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQG 765

  Fly   789 LNNDYVISDYTLLPD-DV---NHDYAQSRAVYRKPLSTEEVCKEIVSQRLAQGFQLIVVDE---- 845
            |.|||....|.|||: |:   :.|..|        ::.::|.:|.:.|||.||:|:||..:
Human   766 LQNDYTEGCYDLLPEADIDRRDEDGVQ--------MTAQQVFEEFICQRLMQGYQIIVQPKTQKP 822

  Fly   846 KPPTASGCSSGSAVQPVKLSR---ETNKEYLLSIGRIFHKISLSGSVITVTGYRPRHPYPPINVD 907
            .|......||........:||   |...:|.||:||.|||::|...:||||.|.|::||....:.
Human   823 NPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIH 887

  Fly   908 YRYRFHAPQHETYEISG--VNFTTEKLENFNWNHMDLYICTRGDVDYPLMESLKYWRYRMYLLPR 970
            |.|.. .|.|...|...  |.|:.|:||.:.||::|.|||:.|..|:.|:||||:||.|..|||
Human   888 YTYSL-CPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLP- 950

  Fly   971 ENIVSKIASCQR-------CDIFPD-VTADNTREQVED-FVRLIEAVSKLKRQY-----ARKARY 1021
                :.:.:.:|       |||:.| ..||....|:.| |||.:|.:::::|::     .||...
Human   951 ----ACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTA 1011

  Fly  1022 LASLLQDSPIAHITKRRHSTSIISRPQPNQGLT-------------------------------- 1054
            :..|....||:     .||....:.|...:|.:
Human  1012 MKGLQMTGPIS-----THSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSA 1071

  Fly  1055 ------------NSP------FRERVGSNRLPEKR--PSINV----RPKLENGRI---------- 1085
                        :||      |.|.|.|.|.....  |.::|    .|.|:...:
Human  1072 ESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDR 1136

  Fly  1086 --PRIFPATDAAAAAGVAARDDQDDGFP--VDIKFSPNATLPEIFEAMKHPVNGVGFFSQTQSLP 1146
              .:.|..:......|.::.:..|....  |....:.::||.||.||||||..||...|:.:.|.
Human  1137 GNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLS 1201

  Fly  1147 SCTFVSYDALMWLKTR---LNNGRHPLDLLEAMRKERMICHASGDWKKPVVPGFVFYYVV---QQ 1205
            ...|:|.:.:.||...   :......:|:::.|.:|::|.||||:..:..:.||.||.:|   :.
Human  1202 PYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEP 1266

  Fly  1206 DKNAKD------YAPPLDDYSAFVNEWLEIEFQGCSFLWHDEPVTTPVPNF----LRDSPAPQSW 1260
            |:.|..      :...:||:::|..:|.|:.|..      :|.|.:.:|.|    |...||..:.
Human  1267 DRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVA------EELVHSEIPAFLLPWLPSRPASYAS 1325

  Fly  1261 TETSSNKRVYRQSH----------------LEIDVNQKSDRMEWGHVKHHTVLQPRFAFEIVVEW 1309
            ..:|.::....:|.                |::|||.::||:||....:|.......||||.:.|
Human  1326 RHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHW 1390

  Fly  1310 VTSSGPIVADLIGGWMRKANQFNF-LVSVPADPMAEPFTKKSDPLRGPIFIPL-CTTFLPNGAA- 1371
            :..:..::.:::.||.|||....| ||.|...|.|.|.....||||..:|||| .:..|..|:.
Human  1391 MAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEH 1455

  Fly  1372 LFDEFPEESRSDRMLFFQEAILGKFGFLPCVLEKKYSVGK-DLPKEY--QYVHCTGNMFALIRCA 1433
            |||.|..|:..|||..|||||..:|||    ::.|||... :.|.|.  ||:|.||.:|..:..:
Human  1456 LFDSFEPETYWDRMHLFQEAIAHRFGF----VQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYS 1516

  Fly  1434 TNNYQVESPILKEANVTRCVYGHTNNTN----VPKKVGFLWAWNHMIPNKKWKAQTINNSADG-E 1493
            ...:..:.         |.....|::||    ..::||:.||:|.|: .|.|:     :||.| |
Human  1517 KRKFSGQQ---------RRRRNSTSSTNQNMFCEERVGYNWAYNTML-TKTWR-----SSATGDE 1566

  Fly  1494 LFQLKMLKDFREFCSNSDQRLSTFWTQSQE 1523
            .|..::||||.:||.|.|.||.||||...|
Human  1567 KFADRLLKDFTDFCINRDNRLVTFWTSCLE 1596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iml1	NP_728621.1	IML1	100..385	CDD:371996	173/284 (61%)
Iml1	NP_728621.1	DEP_DEPDC5-like	1122..1202	CDD:239896	29/82 (35%)
DEPDC5	NP_001229825.1	IML1	101..381	CDD:403468	173/284 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..450		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..527		12/54 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..720		6/57 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1135..1165		3/29 (10%)
		DEP_DEPDC5-like	1179..1260	CDD:239896	28/80 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156680
Domainoid	1	1.000	373	1.000	Domainoid score	I891
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34718
Inparanoid	1	1.050	882	1.000	Inparanoid score	I400
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47488
OrthoDB	1	1.010	-	-		D45642at2759
OrthoFinder	1	1.000	-	-		FOG0005773
OrthoInspector	1	1.000	-	-		oto88417
orthoMCL	1	0.900	-	-		OOG6_103753
Panther	1	1.100	-	-	LDO	PTHR13179
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R606
SonicParanoid	1	1.000	-	-		X4166
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940