DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iml1 and IML1

DIOPT Version :9

Sequence 1:	NP_728621.1	Gene:	Iml1 / 38176	FlyBaseID:	FBgn0035227	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	NP_012672.1	Gene:	IML1 / 853603	SGDID:	S000003899	Length:	1584	Species:	Saccharomyces cerevisiae

Alignment Length:	1708	Identity:	355/1708 - (20%)
Similarity:	645/1708 - (37%)	Gaps:	430/1708 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KSYDADL------------VMNLKDHPNANVGDVVEIYA----PDEENGTHLLLQIT-EFNGSCG 62
            |:|.|:|            ::||.:.|:...||:||:..    |...||...:..|. :|:|...
Yeast   100 KAYQAELGYHESRFSENLVMLNLVEFPDIKPGDLVELKTYHKNPSASNGDKKIYFIAKDFDGETK 164

  Fly    63 RDV----ISIESGIANAFKMRPYSNVVMRIVKP--ADVALDSIEITFKDQYMGRSEMWRLKTYLT 121
            |..    :||.||........|..:.:...:||  .|:..|.:|...||..:.|.:||.|.:.|.
Yeast   165 RRAKTSNVSILSGQLQTLLDLPSRSRIWIKLKPNKFDLQADVVEFNIKDCLLNRGDMWVLSSKLV 229

  Fly   122 DTCVYVNKKIDYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFD 186
            ||||::::::.:.| .||..:..::..|:::.||.|.|.|:|:|||.::.:...:|::.|||:|:
Yeast   230 DTCVFMDQRLAFLD-SIRGTIKGIYRNGKKIVSGYIGEQTRIIFRSESARLIFLIQITDEMWNFE 293

  Fly   187 IHGDLYFEKAVNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQQDYKGRF 251
            ..|:..|:|.||.|..::|:||:.:..:|.:||..       |.|:|......:| |......:.
Yeast   294 ETGEQLFQKMVNSFFPKIFKKWKDVDTHHTITIAF-------AISMDLSDTSFKD-LTPGESLKN 350

  Fly   252 YEDFYRVAIQNERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPATNSSATQGNFLEVLNI 316
            .:|::|:.:.......|..::..||:.|...:..:|.....:...:.....|...:.||||::|.
Yeast   351 SQDYFRIVVDQVSIIHWVDIMETLREEFMEIRKDLLNKQTDKGYSVANGRFSPVIKSNFLELVNF 415

  Fly   317 SLNTFEKHYLDRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAV 381
            :.......:.......|....::|:||.|:|.||..|..:|.::::...:..||:|:.:.|||.|
Yeast   416 ATTILTDPFKQLDLRHTTTHVMIISPGSGLFDVDYSLLRLTGKKLLSLEMTMDLICLSKAPLHIV 480

  Fly   382 PLLKFHNKDTTLTSADDYSLPHWINLSFYSTNKKIVYSSFIPRIKLPLFGSQLTLHDGVGDGEGE 446
            ||.::.:.:..|    .:.:|.|:::.|::.:.|...|.:.||.|  ::..|:     :|..|.|
Yeast   481 PLFRYRDFENKL----HHCVPLWLSVFFWNDHDKKSNSEWTPRCK--IYDLQM-----MGITENE 534

  Fly   447 ---ENERHFLSCNQSEYKHNSLFDY-DAYDEQIFQP--LPAQSTCSLQR--------------VV 491
               |.:..:|..|:   |..||.:: :.||:..|:.  |.|.|.....:              ||
Yeast   535 LIREVDVEYLQLNK---KVKSLSEFMNDYDKNAFEVKILCAGSNTKQSKKLNSKFDTVFENDVVV 596

  Fly   492 RAKKTSVPSLETYAYRNND--WEN-----------LTPTQIPAMRRKMSDPDIH---HGTSAMLA 540
            :|:|  :|:..|..:.|..  |..           ..|..||.:..|..:...:   :.|:..::
Yeast   597 KARK--IPATATTTHGNTKFIWRGPKVALPAIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKIS 659

  Fly   541 ALQPDTTN-----LSESLASEKNSRRTIVSIAPIVRPG---RALINPFDPSQVTIKLTSNRRRWT 597
            .  |.|:|     :::||.|.:::.....|:|.....|   |..:..|....:| |..||
Yeast   660 T--PTTSNNDNLEMNDSLVSVRSADNQNTSLALDSLKGLSKRNSLKDFTQRVIT-KFISN----- 716

  Fly   598 HIFPKGPTGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSNNNNDQEDYGCEN--GEQYDRVSSHSL 660
                                    ....:.:.::.|...::.|....|...  .....::|...|
Yeast   717 ------------------------IDTSKNKKIKSTLLRDDVDNSPLGSNTPLPSSESKISGLKL 757

  Fly   661 LNKSDSSQSFV--MGD----EPIDFFKRRQNSPMNPQPANVPNLTATQAKSYL------------ 707
            ..|..:.::.:  .|:    :.:..|....|..|:..|::....:.|:..|.|
Yeast   758 QQKGLADENVISKRGNLIIKKNLSIFGLPSNEIMSGSPSSYLGSSHTRTSSKLSNMSDKAAFITE 822

  Fly   708 -----------WGATGEQEWTPAITTVKHLRPIVEGEHHHLGSLEALRALDPPPDAEAGGGRGKI 761
                       :..|.:.:...:.|.|....|.:.........|..:|..|..|...|....
Yeast   823 GQKSKHDDSNTYSLTQQLKHRISETWVDIKSPSIPVSSEFANELLPIRWKDVWPKYVARKYS--- 884

  Fly   762 IIGVDWKSLTIPACLPITTDYFPDKRSLNNDYVISDYTLLPDDVNHDYAQSRAVYRKPLSTEEVC 826
                .|:|.|.||.||||...||.|...:.:::..::::   .:|.|..|....|:      ::.
Yeast   885 ----KWRSFTTPAELPITISDFPSKDDFDRNFIFRNHSV---TLNTDQEQYNQTYK------DLL 936

  Fly   827 KEIVSQRLAQGFQLIVVDEKPPTASGCSSGSAVQPVKLSRETNK------EYL-----------L 874
            ::::..||..|||:.|             |..|:.::||||:.:      :||           |
Yeast   937 RDMIYMRLLTGFQICV-------------GRQVEKIELSRESGESETVVNKYLDFNQNDAFKLYL 988

  Fly   875 SIGRIFHKISLSGS-VITVTGYRPRH---------PYPPINVDYRYRFHAPQHETYEISGVNFTT 929
            .|....|:|:.|.| :|.|..|..:.         .|.|: |..||      ..::..:.::...
Yeast   989 MIDSEIHRITCSSSGIIDVERYLRKDEANLFDQVPSYIPL-VKTRY------ESSFRDAMIDPLH 1046

  Fly   930 EKLENFNWNHMDLYICTRGD--VDYPLMESLKYW---RYRMYLLPRE---NIVSKIASCQRCDIF 986
            .|.|:.|||.:|..:...||  :|       :.|   |.:..:||.:   |..|.:.:.:...:.
Yeast  1047 VKRESLNWNQIDQVLAGYGDNLID-------RKWHGFRAKYVVLPTDIPPNTYSMVINGKSETLN 1104

  Fly   987 PDVTADNTREQVEDFVRLIEAV--SKLKRQYARKARYLASLLQDSPIAHITKRRHSTSIISRPQP 1049
            |:      ..:||...|||.::  |:|:.:..:|.|.             |||...       ||
Yeast  1105 PE------EIRVEGLRRLIGSITRSRLRTEKEKKGRK-------------TKREEI-------QP 1143

  Fly  1050 NQGLTNSPFRERVGSNRLPEKRPSINVRPKL---ENGRIPRIFPATDAAAAAGVAARDDQDDGFP 1111
            .......|....:...:...:..:||.:..:   :|..:.|
Yeast  1144 EVMFYTGPLYNFINEQQTSLESSAINFKDSIFVNDNNLLNR------------------------ 1184

  Fly  1112 VDIKFSPNATLPEIFEAMKHPVNGVGFFSQT---QSLPSCTFVSYDALMWLKTRLNNGRHPLDLL 1173
                   |..|.::...::...:.:...::.   :....| ||..:.:.||....::    :|..
Yeast  1185 -------NVELSKLAYQIQRGEDRITLVNRKWHWKKHEKC-FVGSEMVNWLIRNFSD----IDTR 1237

  Fly  1174 E-------AMRKERMICHASGDWKKPVVPGFVFY-----YVVQQDKNAK--DYAPPLDDYSAFVN 1224
            |       .:.||.:..|...  |...:.|..||     ||:..:|..|  .:...|.|    ..
Yeast  1238 EDAIKYGQKVMKEGLFVHVLN--KHNFLDGHYFYQFSPEYVMDTNKLEKTNSHRSTLSD----PK 1296

  Fly  1225 EWLEIEFQGCSFLWHDEPVTTP----VPNF------LRDSPAPQSWTETSSNKRVYRQSHLEIDV 1279
            :.|.....|.|   :|....||    ||..      :.|:..|.......||..|     :::|.
Yeast  1297 QMLRKASTGSS---NDPSAMTPFSSVVPAISASNASVADAKEPSRPILMLSNSLV-----IDVDP 1353

  Fly  1280 NQKSDRMEWGHVKHHTVLQPRFAFEIVVEWVTSSGPIVADLIGGWMRKANQFNF-LVSVPAD--- 1340
            ..||.:.|...|.:..|..|...|.|.:||:|::..::.||:|.|.|...::.. ::.:|.:
Yeast  1354 AGKSSKQESCTVHYDRVHNPDHCFHIRLEWLTTTPKLIDDLVGNWSRLCERYGLKMIEIPWEELC 1418

  Fly  1341 --PMAEPFTKKSDPLRGPIFIPLCTTFLPNGAALFDEFPEESRSDRMLF------FQEAILGKFG 1397
              |...||..         |:.:.....|        :.:....||.||      :...:|...|
Yeast  1419 TIPSVNPFHS---------FVEIKLAINP--------WEDPEFKDRELFAKSKFYYHVYLLKASG 1466

  Fly  1398 FLPCVLEKK---------------YSVGKDLPKEYQYVHCTGNMFALIR---C---ATNNYQVES 1441
            ||   |:.:               ||.||...|..||:|.||...|.:|   |   |.||..:
Yeast  1467 FL---LDNRASKFLQNQDIEFDIMYSWGKPQFKYVQYIHHTGAYVAELRENGCLFLAPNNIYI-- 1526

  Fly  1442 PILKEANVTRCVYGHTNNTNVPKKVGFLWAWNHMIPNKKWKAQTINNSADGELFQLKMLKDFREF 1506
                         ...|..|:..|                    |::::...|...|::.:|:..
Yeast  1527 -------------SRVNPGNIIGK--------------------IHSASSSSLDAQKVILNFKST 1558

  Fly  1507 CSNSDQRLSTFWTQSQEL 1524
            |.:. |:|.:.:..::|:
Yeast  1559 CLDY-QKLRSIFLDAKEM 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iml1	NP_728621.1	IML1	100..385	CDD:371996	79/284 (28%)
Iml1	NP_728621.1	DEP_DEPDC5-like	1122..1202	CDD:239896	15/94 (16%)
IML1	NP_012672.1	IML1	208..484	CDD:403468	79/284 (28%)
IML1	NP_012672.1	DEP_DEPDC5-like	1188..1271	CDD:239896	15/89 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345494
Domainoid	1	1.000	153	1.000	Domainoid score	I915
eggNOG	1	0.900	-	-		E1_KOG3572
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	276	1.000	Inparanoid score	I576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005773
OrthoInspector	1	1.000	-	-		oto98981
orthoMCL	1	0.900	-	-		OOG6_103753
Panther	1	1.100	-	-	LDO	PTHR13179
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R606
SonicParanoid	1	1.000	-	-		X4166
TreeFam	0	0.000	Not matched by this tool.
	10	9.910