DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iml1 and depdc5

DIOPT Version :9

Sequence 1:	NP_728621.1	Gene:	Iml1 / 38176	FlyBaseID:	FBgn0035227	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	XP_021334975.1	Gene:	depdc5 / 562995	ZFINID:	ZDB-GENE-091204-356	Length:	1614	Species:	Danio rerio

Alignment Length:	1718	Identity:	595/1718 - (34%)
Similarity:	870/1718 - (50%)	Gaps:	315/1718 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLYKLNTHTRGCNKSYDADLVMNLKDHPNANVGDVVEIYAPDEENGTHLLLQITEFNGSCGRDVI 66
            |.|||..|.:|...| |.:|:||.|..|...:||:|||..|::|. :.||||:........::.|
Zfish     9 KSYKLVVHKKGFGGS-DDELMMNPKVFPQVKLGDIVEIAHPNDEY-SPLLLQVKSLKEDLQKETI 71

  Fly    67 SIESGIANAFKMRPYSNVVMRIVKPADVALDSIEITFKDQYMGRSEMWRLKTYLTDTCVYVNKKI 131
            |::..:|.|||:|.|.:|::.||.|.:|.||.:|:||||||:||.:|||||..|..||.||.:|:
Zfish    72 SVDQTVAQAFKLRAYQDVIINIVDPKEVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYVTQKV 136

  Fly   132 DYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGDLYFEKA 196
            ::  ..||.|..|:|.:||:|..|.|:|||::||||:::|||:|:|||.|||||||:||||||||
Zfish   137 EF--AGIRAQASELWVKGEKVTCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKA 199

  Fly   197 VNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQQDYKGRFYEDFYRVAIQ 261
            |||||::||.||::.:|:||||:||||||||:||:|:||||..|..::||::||:|||||||..|
Zfish   200 VNGFLSDLFAKWKEKNCSHEVTVVLFSRTFYSAKTLEEFPESQRASVRQDHEGRYYEDFYRVVAQ 264

  Fly   262 NERCDDWCTVLGQLRKLFTSYQATVLRYHERENMK----IPPATNSSATQGNFLEVLNISLNTFE 322
            |||.|:|.::|..::|||..|...|       .:|    .|...||::.|||:||.:|:|.|.|:
Zfish   265 NERRDEWMSLLVTIKKLFIQYPVLV-------RLKGADGFPCGHNSTSAQGNYLEAINLSFNVFD 322

  Fly   323 KHYLDRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFH 387
            |||::|.||||||:|||||||||||.|||.|..:||||:||||:|.||||:||||||||||.|.|
Zfish   323 KHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLH 387

  Fly   388 NK----DTTLTSADDYSLPHWINLSFYSTNKKIVYSSFIPRIKLPLFGSQLTLHDGVGDGEGEEN 448
            |:    |:.:  .|||:||||||.|||::..:...|.|.|||||.  |.:      |...:.:.:
Zfish   388 NRTVHGDSRI--GDDYNLPHWINHSFYTSKSQNSCSCFTPRIKLA--GKK------VHAEKAKNS 442

  Fly   449 ERHFLSCNQSEYKHNSL---FDYDAYDEQIFQ-PLPA---QSTCSLQRVVRAKKTSVPSLETYAY 506
            :.|.|...:.  ..|||   .||||||.|:|: |.|:   :||......:.:..::..|.|..:.
Zfish   443 KEHSLGAPKD--AENSLPIQVDYDAYDSQVFRLPGPSRAQRSTNFSSSHINSTDSNRSSRERESV 505

  Fly   507 RNNDWENLTPTQIP--------AMRRKMSDPDIHHGTSAML----AALQPDTTN----------- 548
            ....|.:......|        ..|...||..:.|.::.:|    |..|.:.::
Zfish   506 SRKSWGSADVGSSPPNRHTGPDEQRSLASDDSLGHMSNILLIPRPAQGQYEVSSSLGYTSCTREL 570

  Fly   549 LSESLASEKNS----RRTIVSIAPI--VRPG-----RALINPFDPSQVTIKLTSNRRRWTHIFPK 602
            |.:.:.|:::|    |.|:.|....  ||||     |||||||.||::.:|||||||||.|.||.
Zfish   571 LEKMVESQRDSSAPGRFTVGSAESTLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPV 635

  Fly   603 GPTGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSN----NNNDQEDYGCENGEQYDRVSSHSLLNK 663
            ||:|..||.||                  ||:.|    ..::|.|....:.|..:.....:..:|
Zfish   636 GPSGEPIQIHH------------------QTRQNMAELQGSEQRDPARTSAELLELAYHEATGSK 682

  Fly   664 SDSSQSFVMGDEPIDFFKRRQNSPMNPQPANVP-NLTATQAKSYLWGATGEQEWTPAITTVKHLR 727
            ..:|:.  .|:..:..             :.|| |::.:.|.|   .:||              .
Zfish   683 RTASRH--AGENGLYI-------------SGVPDNISGSPASS---SSTG--------------T 715

  Fly   728 PIVEGE-HHHLGSLEALRALDPPPDAEAGGGRGKIIIGVDWKSLTIPACLPITTDYFPDKRSLNN 791
            |:..|. ..:.|||:.:..|..||...:    ....:||||||||.|||||:|||||||:::|.|
Zfish   716 PVNRGSFEDYSGSLDPILLLSAPPTVPS----FCCTVGVDWKSLTTPACLPLTTDYFPDRQTLQN 776

  Fly   792 DYVISDYTLLPDDVNHDYAQSRAVYRKPLSTEEVCKEIVSQRLAQGFQLIVVDEK---PPTASGC 853
            ||....|.|||    |...:.|......::..:|.:|.:.|||.||:|:||...:   |..|...
Zfish   777 DYTEGCYDLLP----HTDLERRDDETPVMTAHQVFEEFICQRLMQGYQIIVQPNRKPQPAIAPPL 837

  Fly   854 SSGSAVQPVKLSRETNKE----YLLSIGRIFHKISLSGSVITVTGYRPRHPYPPINVDYRYRF-- 912
            ||........:||...:|    |.||:||.|||:.|...:||||.|.|::||....:.|.|..
Zfish   838 SSSPLYSRGLVSRRKPEEEESLYWLSMGRTFHKVCLKDKIITVTRYLPKYPYESTQIQYSYNLCP 902

  Fly   913 -HAPQHETYEISGVNFTTEKLENFNWNHMDLYICTRGDVDYPLMESLKYWRYRMYLLPRENIVSK 976
             ||..|  :....|.|:.|:||.:.||::|.|||:.|..|:.|::|||:||.|..|||... ..:
Zfish   903 PHADAH--FMPFWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIDSLKFWRTRFLLLPAGG-ARR 964

  Fly   977 IASCQ-RCDIFPD----------VTADNTREQVEDFVRLIEAVSKLKRQY-----ARKARYLASL 1025
            :|..: ..|::.:          .|.|.|  .::.|:|.:|.:::::|::     .||...:..|
Zfish   965 VADGEGHWDVYGEGAGAGRDGLAGTGDWT--LLDGFIRFLEGLNRIRRRHRSDRMIRKGATIKGL 1027

  Fly  1026 LQDSPIAHITKR-------RHSTSIIS-----------------------RP------QPNQGLT 1054
            .....:...|..       :..||.:|                       :|      ..|..||
Zfish  1028 QVTGALTSYTPEPIAPPLGKKGTSALSALLELEQTQKTFEEQQLAAQHGGKPCGPFSEAANVALT 1092

  Fly  1055 ------------------NSPFRERVGSNRLPEKRPSINVRPKLENGRIPRIFPATDAAAAAGVA 1101
                              .||....:..::||.::...|   .:|.|...:|........:|...
Zfish  1093 TTFVDSPRKDAAFILDFIRSPRSSYICHSQLPAEQVPAN---PIEGGLSDKISNQPGERTSAASQ 1154

  Fly  1102 ARDDQDDGFPVD---------IKFSPNATLPEIFEAMKHPVNGVGFFSQTQSLPSCTFVSYDALM 1157
            |..|...|..::         :..|.::||.||.||:|||..||....:.:.||...|||.:.:.
Zfish  1155 ATGDPTPGASLETGGQSGSSGLSLSSSSTLMEILEAIKHPTTGVQLLPEQRGLPPNCFVSAEVVH 1219

  Fly  1158 WLKTRLNNGRH---PLDLLEAMRKERMICHASGDWKKPVVPGFVFYYVVQQD--KNAKDYAPP-- 1215
            ||.:.:.|...   .:::::.|.:|.:|.|||||..:..|.||.||.:|.:|  |......||
Zfish  1220 WLVSTVENVATQGIAVEIMQKMLEEGLITHASGDAMRTFVYGFYFYRIVDKDNEKAPLTQLPPAG 1284

  Fly  1216 --------LDDYSAFVNEWLEIEFQGCSFLWHDEPVTTP---VPNFLRDSPAPQSWTETSSNKRV 1269
                    |:|::.|..:|.|:.|    .:....|...|   :| :|...||..:...:|.::..
Zfish  1285 ANVWSAAALEDFALFQRKWFEVAF----VMEERRPCDLPAFLLP-WLPSRPASYASRHSSFSRSF 1344

  Fly  1270 YRQSH----------------LEIDVNQKSDRMEWGHVKHHTVLQPRFAFEIVVEWVTSSGPIVA 1318
            ..:|.                |::|||.:|||.||....:|.......||||.:.|:..:..::.
Zfish  1345 GGRSQAAALLAATVPEQKTVTLDVDVNNRSDRTEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLF 1409

  Fly  1319 DLIGGWMRKANQFNFLVSVPADPMAEPFTKKS----DPLRGPIFIPL---CTTFLPNGA-ALFDE 1375
            :::.||.|||....||: ||.  :..||...|    ||||..:||||   |  .|..|: .||:.
Zfish  1410 EMVQGWHRKAASCGFLL-VPV--LEVPFALSSYLYGDPLRAQLFIPLNIQC--LLKEGSDNLFEG 1469

  Fly  1376 FPEESRSDRMLFFQEAILGKFGFLPCVLEKKYSVGK-DLPKEY--QYVHCTGNMFALIRCATNNY 1437
            |..|:..|||..||||||.:|||    ::.|:|... :.|.|.  ||:|.||.:|..:..:...|
Zfish  1470 FEPETYWDRMQLFQEAILTRFGF----VQDKFSASAFNFPSENKPQYIHVTGTVFLQLPYSKRKY 1530

  Fly  1438 QVESPILKEANVTRCVYGHTNNTN-----VPKKVGFLWAWNHMIPNKKWKAQTINNS--ADGELF 1495
                     ::..|.....|.:||     ..::||:.||:|.|: .|.|:...:.:.  ||
Zfish  1531 ---------SSGQRRRRNSTTSTNQSLFGSEERVGYNWAYNTML-TKAWRTGVLGDEKLAD---- 1581

  Fly  1496 QLKMLKDFREFCSNSDQRLSTFWTQSQE 1523
              ::|:||.:||:|.|.||.|||....|
Zfish  1582 --RLLRDFTDFCANKDNRLVTFWESCVE 1607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iml1	NP_728621.1	IML1	100..385	CDD:371996	173/288 (60%)
Iml1	NP_728621.1	DEP_DEPDC5-like	1122..1202	CDD:239896	31/82 (38%)
depdc5	XP_021334975.1	IML1	111..385	CDD:315028	168/282 (60%)
depdc5	XP_021334975.1	DEP_DEPDC5-like	1184..1267	CDD:239896	31/82 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592298
Domainoid	1	1.000	373	1.000	Domainoid score	I847
eggNOG	1	0.900	-	-		E1_KOG3572
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34718
Inparanoid	1	1.050	862	1.000	Inparanoid score	I405
OMA	1	1.010	-	-		QHG47488
OrthoDB	1	1.010	-	-		D45642at2759
OrthoFinder	1	1.000	-	-		FOG0005773
OrthoInspector	1	1.000	-	-		oto39790
orthoMCL	1	0.900	-	-		OOG6_103753
Panther	1	1.100	-	-	LDO	PTHR13179
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R606
SonicParanoid	1	1.000	-	-		X4166
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840