DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Iml1 and Depdc5

DIOPT Version :9

Sequence 1:	NP_728621.1	Gene:	Iml1 / 38176	FlyBaseID:	FBgn0035227	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	XP_038947914.1	Gene:	Depdc5 / 305464	RGDID:	1311535	Length:	1601	Species:	Rattus norvegicus

Alignment Length:	1722	Identity:	611/1722 - (35%)
Similarity:	868/1722 - (50%)	Gaps:	332/1722 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLYKLNTHTRGCNKSYDADLVMNLKDHPNANVGDVVEIYAPDEENGTHLLLQITEFNGSCGRDVI 66
            |:|||..|.:|...| |.:||:|.|..|:..:||:|||..|::|. :.||||:........::.|
  Rat     5 KVYKLVIHKKGFGGS-DDELVVNPKVFPHIKLGDIVEIAHPNDEY-SPLLLQVKSLKEDLQKETI 67

  Fly    67 SIESGIANAFKMRPYSNVVMRIVKPADVALDSIEITFKDQYMGRSEMWRLKTYLTDTCVYVNKKI 131
            |::..:...|::|||.:|.:.:|.|.||.||.:|:||||||:||.:|||||..|..||.|:.:|:
  Rat    68 SVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKV 132

  Fly   132 DYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGDLYFEKA 196
            ::  ..||.|..|:|.:.|:|..|.|:|:|::||||:::|||:|:|||.|||||||:||||||||
  Rat   133 EF--AGIRAQAGELWVKNEKVMCGYISEETRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKA 195

  Fly   197 VNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQQDYKGRFYEDFYRVAIQ 261
            |||||.:||.||::.:|:||||:||||||||.|||:|||||..|..:|||:|||||||||:|.:|
  Rat   196 VNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSIDEFPEVNRASIQQDHKGRFYEDFYKVVVQ 260

  Fly   262 NERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPATNSSATQGNFLEVLNISLNTFEKHYL 326
            |||.::|.::|..::|||..|...| |..:...  .|...||::.|||:||.:|:|.|.|:|||:
  Rat   261 NERREEWTSLLVTIKKLFIQYPVLV-RLEQAGG--FPQGDNSTSAQGNYLEAINLSFNVFDKHYI 322

  Fly   327 DRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKDT 391
            :|.||||||:|||||||||||.|||.|..:||||:||||:|.||||:||||||||||.|.||:..
  Rat   323 NRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSV 387

  Fly   392 TLTS--ADDYSLPHWINLSFYSTNKKIVYSSFIPRIKLPLFGSQLTLHDGVGDGEGEENERHFLS 454
            ...|  .|||::|||||.|||::..::..:||.|||||.  |.:...       |..:|.|. .|
  Rat   388 PRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLA--GKKSAT-------EKTKNGRD-TS 442

  Fly   455 CNQSEYKHNSL---FDYDAYDEQIFQ---PLPAQ--STCSLQRVVRAKK------------TSVP 499
            ....:...|:|   .||||||.|:|:   |..||  :||   |.||.::            :|.|
  Rat   443 LGAPKESENTLPIQVDYDAYDAQVFRLPGPSRAQRLATC---RSVREQENHNRKSASSCDVSSSP 504

  Fly   500 SLETYAYRNNDWENLTPTQIPAMRRKMSDPDIHHGTSAMLAALQPDTTNLSESLASEKNSRRTIV 564
            ||.:.|         .||:  .:|.:.||......::.:|....|.......|.:....|.|..|
  Rat   505 SLPSRA---------LPTE--EVRSQASDDSSLGKSTNILMIPNPHLHQYEVSSSLGYTSTRADV 558

  Fly   565 -----------SIAP------------IVRPG-----RALINPFDPSQVTIKLTSNRRRWTHIFP 601
                       |.||            .||||     |||||||.||::.:|||||||||.|.||
  Rat   559 LENMIEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFP 623

  Fly   602 KGPTGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSNNNNDQEDYGCENGEQYDRVSSHSLLNKSDS 666
            .||:|..||.||.........|..:||  ..|.|:....:..|       ::....||...:...
  Rat   624 VGPSGEAIQIHHQTRQNMAELQGSRQR--DPTHSSAELLELAY-------HEAAGRHSTSRQPGD 679

  Fly   667 SQSF-VMGDEPIDF-FKRRQNSPMNPQPANVPNLTATQAKSYLWGATGEQEWTPAITTVKHLRPI 729
            |.|. ..|.|.:.. ......:.|||:..|..:|                  ...::|
  Rat   680 SMSLNFSGTEELSVSLLSNSGTGMNPRNQNKDSL------------------EDGVST------- 719

  Fly   730 VEGEHHHLGSLEALRALDPPPDAEAGGGRGKII------IGVDWKSLTIPACLPITTDYFPDKRS 788
                     |.:.:..|..||          ::      :||||||||.|||||:|||||||::.
  Rat   720 ---------SPDPILTLSAPP----------VVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQG 765

  Fly   789 LNNDYVISDYTLLPDDVNHDYAQSRAVYRKPLSTEEVCKEIVSQRLAQGFQLIV--VDEKPPTA- 850
            |.|||....|.||| :.:.|......|   .::.::|.:|.:.|||.||:|:||  ..:||.|.
  Rat   766 LQNDYTEGCYDLLP-EADMDRRDEEGV---QMTAQQVFEEFICQRLMQGYQIIVQPKTQKPSTTV 826

  Fly   851 -SGCSSGSAVQPVKLSR---ETNKEYLLSIGRIFHKISLSGSVITVTGYRPRHPYPPINVDYRYR 911
             ...||........:||   |...:|.||:||.|||::|...:||||.|.|::||....:.|.|.
  Rat   827 PPPLSSSPLYSRGLVSRNRPEEEGQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYS 891

  Fly   912 FHAPQHETYEISG--VNFTTEKLENFNWNHMDLYICTRGDVDYPLMESLKYWRYRMYLLPRENIV 974
            . .|.|...|...  |.|..|:||.:.||::|.|||:.|..|:.|:||||:||.|..|||
  Rat   892 L-CPSHSDSEFVSCWVEFCHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLP----- 950

  Fly   975 SKIASCQR-------CDIFPD-VTADNTREQVED-FVRLIEAVSKLKRQY-----ARKARYLASL 1025
            :.:.:.:|       |||:.| ..||....|:.| |:|.:|.:::::|::     .||...:..|
  Rat   951 ACVTATKRITEGEVHCDIYGDKPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMIRKGTAMKGL 1015

  Fly  1026 LQDSPIAHITKRRHSTSIISRPQPNQG-------LTNSPFRERVG---------SNRLPEKRPSI 1074
            ....||:     .||......|...:|       |.....::.:|         |:..|.:..|:
  Rat  1016 QMTGPIS-----AHSLESTGPPVGKKGTSALSALLEMEASQKSLGEQQTSVHGKSSTQPAENSSV 1075

  Fly  1075 NVRPK------------LENGRIPR-----IFP--ATDAAA-------AAGVAARDDQDDG---- 1109
            .:.|.            :|..|.||     .:|  :.|..|       :.||:.....|.|
  Rat  1076 AMTPTYVDSPRKDGAFFMEFVRSPRTASSAFYPQASVDQTAPLVLDSTSLGVSTCQSVDRGNNQT 1140

  Fly  1110 ----------FP------------VDIKFSPNATLPEIFEAMKHPVNGVGFFSQTQSLPSCTFVS 1152
                      ||            :....:.::||.||.||||||..||...|:.:.|..|.|:|
  Rat  1141 FGNSQNIEQAFPSTGSGDGSSQQHIASSLTSSSTLVEILEAMKHPSTGVQLLSEQKGLSPCCFIS 1205

  Fly  1153 YDALMWLKTRLNN---------GRHPLDLLEAMRKERMICHASGDWKKPVVPGFVFYYVV----- 1203
            .:.:.||   :||         |   :|:::.|.:|::|.||||:..:..|.||.||.:|
  Rat  1206 AEVVHWL---MNNVEGVQTQAMG---IDIMQKMLEEQLIAHASGEAWRTFVYGFYFYKIVTDREP 1264

  Fly  1204 ----QQDKNAKDYAPPLDDYSAFVNEWLEIEFQGCSFLWHDEPVTTPVPNF----LRDSPAPQSW 1260
                .|..:|..:...:||:::|..:|.|:.|..      :|.|.:.:|.|    |...||..:.
  Rat  1265 ERVAMQQPSAPWHTAGVDDFASFQRKWFEVAFVA------EELVHSEIPAFLLPWLPSRPASYAS 1323

  Fly  1261 TETSSNKRVYRQSH----------------LEIDVNQKSDRMEWGHVKHHTVLQPRFAFEIVVEW 1309
            ..:|.::....:|.                |::|||.::||:||....:|.......||||.:.|
  Rat  1324 RHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHW 1388

  Fly  1310 VTSSGPIVADLIGGWMRKANQFNF-LVSVPADPMAEPFTKKSDPLRGPIFIPL---CTTFLPNGA 1370
            :..:..::.:::.||.|||....| ||.|...|.|.|.....||||..:||||   |  .|..|:
  Rat  1389 MAVTATVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNLGC--LLKEGS 1451

  Fly  1371 A-LFDEFPEESRSDRMLFFQEAILGKFGFLPCVLEKKYSVGK-DLPKEY--QYVHCTGNMFALIR 1431
            . |||.|..|:..|||..|||||..:|||    ::.|||... :.|.|.  ||:|.||.:|..:.
  Rat  1452 EHLFDSFEPETYWDRMHLFQEAIAHRFGF----VQDKYSASAFNFPAENKPQYIHVTGTVFLQLP 1512

  Fly  1432 CATNNYQVESPILKEANVTRCVYGHTNNTN----VPKKVGFLWAWNHMIPNKKWKAQTINNSADG 1492
            .:...:..:.         |.....|::||    ..::||:.||:|.|: .|.|:     :||.|
  Rat  1513 YSKRKFSGQQ---------RRRRNSTSSTNQNMFCEERVGYNWAYNTML-TKTWR-----SSATG 1562

  Fly  1493 -ELFQLKMLKDFREFCSNSDQRLSTFWTQSQE 1523
             |.|..::||||.:||.|.|.||.||||...|
  Rat  1563 DEKFADRLLKDFTDFCINRDNRLVTFWTNCLE 1594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Iml1	NP_728621.1	IML1	100..385	CDD:371996	172/284 (61%)
Iml1	NP_728621.1	DEP_DEPDC5-like	1122..1202	CDD:239896	34/88 (39%)
Depdc5	XP_038947914.1	IML1	101..381	CDD:403468	172/284 (61%)
Depdc5	XP_038947914.1	DEP_DEPDC5-like	1177..1258	CDD:239896	33/86 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350599
Domainoid	1	1.000	372	1.000	Domainoid score	I864
eggNOG	1	0.900	-	-		E1_KOG3572
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34718
Inparanoid	1	1.050	882	1.000	Inparanoid score	I380
OMA	1	1.010	-	-		QHG47488
OrthoDB	1	1.010	-	-		D45642at2759
OrthoFinder	1	1.000	-	-		FOG0005773
OrthoInspector	1	1.000	-	-		oto95557
orthoMCL	1	0.900	-	-		OOG6_103753
Panther	1	1.100	-	-	LDO	PTHR13179
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4166
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810