Protein Alignment Iml1 and SPBC26H8.04c

DIOPT Version :9

• Sequence 1: NP_728621.1
• Gene: Iml1 / 38176
• FlyBaseID: FBgn0035227
• Length: 1544
• Species: Drosophila melanogaster
• Sequence 2: NP_596645.1
• Gene: SPBC26H8.04c / 2540559
• PomBaseID: SPBC26H8.04c
• Length: 1496
• Species: Schizosaccharomyces pombe
• Alignment Length: 1759
• Identity: 397/1759 - (22%)
• Similarity: 656/1759 - (37%)
• Gaps: 574/1759 - (32%)

  Fly    20 DLVMNLKDHPNANVGDVVEIYAPDEENGTHLLLQITEFNGSCGR-------------------DV 65
            |.|:|....|:|..||:.||.|   :||..:.||  ..:.|.|:                   |:
pombe    18 DAVLNYDLVPSAKPGDIFEIRA---QNGDEIALQ--HNHSSTGKLHAKREKEPVYLMPSPLTDDL 77

  Fly    66 --------ISIESGIANAFKMRPYSNVVMRIVK-PADVALDSIEITFKDQYMGRSEMWRLKTYLT 121
                    :|:.|.|::...::....||::|.: ..::..:.:.|.|:||::.||:||:|...|.
pombe    78 KRRHPNLQLSVVSHISSLLNIKNREPVVVKICEDKTNLEAEHVVIFFRDQFISRSDMWKLFRELC 142

  Fly   122 DTCVYVNKKIDY-NDM--QIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMW 183
            ..|||:.:::.: .|:  :|||    :|.:|::..|..|:|.||.:|||.::...:|:|||.|||
pombe   143 GKCVYLKQRVSFIGDVPGEIRC----IWRKGKKCHSAYISERTKPIFRSESARFLIFIQMSEEMW 203

  Fly   184 DFDIHGDLYFEKAVNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQQ--- 245
            .|:..|:|.:.||::|||.:||..||.|..:|.|:|:||:|.        |:..|...|:.|
pombe   204 HFEEDGELNYNKAIDGFLPDLFSFWRDLGTHHLVSIILFTRV--------EYSHHGPMCVWQPRS 260

  Fly   246 --------------------DYKGRFYEDFYRVAIQNERCDDWCTVLGQLR-KLFTSYQATVLRY 289
                                |.:|..||||::|.:.|....||..||..|: :|....|..::|.
pombe   261 QKNSEKGSSIYPQNSFNASIDNEGGPYEDFFKVVVDNVSSRDWQPVLANLKLELAKFRQDVIVRK 325

  Fly   290 HEREN---MKIPPATNSSATQGNFLEVLNISLNTFEKHYLDRTFDRTGQLSVVITPGVGVFSVDR 351
            .:.||   ::......:.:.:||||||:|:::..|:..|:||...|||...:::|||.|::.|:.
pombe   326 IKDENGREIEYICGRMTGSQEGNFLEVINMAVFQFQSDYIDRDLSRTGTSIIIVTPGTGLYEVNE 390

  Fly   352 ELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHN-----KDTTLTS---------------- 395
            ::.::|.:.:::..||.|:|.:|:.||...|::::.|     |.:.|||
pombe   391 KMLHLTSKSLLNTVVGMDIVSLGKVPLFLTPIVRYKNPVKNKKRSQLTSRISSSVSPSNVIPNSL 455

  Fly   396 ----------------ADD----YSLPHWINLSFYSTNKKIVYSS----------FIP------- 423
                            .:|    |:.|...|:|||||.:.....|          |.|
pombe   456 TSSVSNFSVSSFLNNLKEDTEWLYTFPIGCNISFYSTTEMRSLRSPWENLMREHQFEPTAKMHEL 520

  Fly   424 -----------RIKLPLFGSQLTLHDGVGDGEGEE--NERHF-----LSCN----QSEYKHNSLF 466
                       :|.:||..|...|...|...|.:|  :||.|     :|.|    .|..:|.|..
pombe   521 QMMGVLEAESAKISIPLLQSDPLLKGSVFSEEVQEDYDERQFTGEAAVSANDVLSSSSPRHFSSH 585

  Fly   467 DYDAYDEQIFQPLPAQSTCSLQRVVRAKKTSVPSLETYAYRNNDWENLTPTQIPAMRRKMSDPDI 531
            .....|:..:..:...   ||..|:..|:    |:.::..:.:|   |..|...:.|:
pombe   586 TPVNVDKSSYLEMNGH---SLSTVISGKE----SISSFGAKVDD---LKSTSKESARQ------- 633

  Fly   532 HHGTSAMLAALQP---DTTNLSESL---ASEKNSRRTIVSIAPIVRPGRALINPFDPSQVTIKLT 590
             .|.||:...||.   :::|:|.||   :|.|:|..|..|..|      ||:..|.....|:..:
pombe   634 -FGKSALTERLQKLAGNSSNVSSSLQTSSSNKSSLLTKKSSFP------ALLKGFLALPATVTTS 691

  Fly   591 SNRRRWTHIFPKGPTGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSNNNNDQEDYGCENGEQYDRV 655
            :|           |.|.               ::..|||:   ...||.|
pombe   692 AN-----------PLGF---------------KSTIQRPI---PIKNNED--------------- 712

  Fly   656 SSHSLLNKSDSSQSF-----VMGDEPIDFFKRRQNSPMNPQPAN--VPNLTATQAKSYLWGATGE 713
                    |||.::|     :...:|..|.|     |.:|:.|.  :|..:......|      :
pombe   713 --------SDSCKAFSQAPPIATKKPPTFLK-----PNSPEYAKTVIPKSSTNLENEY------Q 758

  Fly   714 QEW----TP---AITTVKHLRPIVEGEHHHLGSLEALRALDPPPDAEAGGGRGKIIIGVDWKSLT 771
            ..|    .|   ..||..:....:..||.:: .::.:|..                   :|.|:.
pombe   759 TPWKIIQNPFKLKETTADNDPVSLRWEHLYM-KVQDVRKF-------------------NWLSMC 803

  Fly   772 IPACLPITTDYFPDKRSLNNDYVISDYTLLPDDVNHDYAQSRAVYRKPLSTEEVCKEIVSQRLAQ 836
            .|..||:|..|||.:..||:.:....||:   .::.::.|        ::.:|:..|::.|||::
pombe   804 TPGALPLTFSYFPSEEELNDKFEEYTYTI---GIDPEFTQ--------MNQQELLAEMICQRLSR 857

  Fly   837 GFQLIVVDEKPPTASGCSSGS-----AVQPVKLSRETNKE-----------YLLSIG-RIFHKIS 884
            |:|::|    .|.|:...||:     |......||..|.:           ..||:| ..||::|
pombe   858 GYQIVV----NPAAAVSYSGNPKANKAGTITDFSRSVNNQRNGHLTVGSDAVCLSLGDSQFHRLS 918

  Fly   885 LSGSVITVTGYRPRHPYPPINVD---------------YRYRFHAPQHETYEISGVNFTTEKLEN 934
            ...     .||         |::               |.|.|.:.....|..|.:.|:.....|
pombe   919 CDS-----VGY---------NIEVKRYVKKVSGQGKMRYDYNFWSKNECKYVKSNITFSANDSAN 969

  Fly   935 FNWNHMDLYICTRGDVDYPLMESLKYWRYRMYLLPRE----NIVSKIASCQRCDIFPDVTADNTR 995
            :|||::|..||  |...| |.:|:||||.|..|||..    ::..|.......|...|
pombe   970 YNWNYVDQLIC--GFETY-LPDSVKYWRARFVLLPMSTTSTHVFQKYQLLDHADALSD------- 1024

  Fly   996 EQVEDFVRLIEAVSKLKRQYARKARYLASLLQDSPIAHITKRRHSTSIISRPQPNQGL--TNSPF 1058
               |:|  .:|.:.|           |:.||....|..:....:.|...| |....|:  |..|.
pombe  1025 ---EEF--RVEGIYK-----------LSELLYKGKIDPMNDSNNKTPNTS-PAELLGIKFTTLPM 1072

  Fly  1059 RE---------RVGSNR------LPEKRPSINVRPKLENGRIPRIFPATDAAAAAGVAARDDQDD 1108
            .:         |:.|:|      :|.||                    .|.:|.....|::.|..
pombe  1073 AQYIHSELEALRLDSSRNEQSLFMPNKR--------------------LDCSADLHTIAKEIQGP 1117

  Fly  1109 GFPVDIKFSPNATLPEIFEAMKHPVNGVGFFSQTQSLPSCTFVSYDALMWLKTR---LNNGRHPL 1170
            |.|   |.........|:|                   :| |:..:.:.||...   :|.....|
pombe  1118 GGP---KIDDITWHYRIYE-------------------NC-FLGSEFVSWLANTFIGINTREEAL 1159

  Fly  1171 DLLEAMRKERMICHASGDWKKPVVPGFVFYYVVQQDKNAKDYAPPLDDYSAFVNEWLEIEFQGCS 1235
            .....:....:..||..  |.|::.|:..|.:          :|   |||
pombe  1160 KYGNKLLSLGLFDHALK--KHPLLDGYYVYRI----------SP---DYS--------------- 1194

  Fly  1236 FLWHDEPVTTPVPNFLRDSPAP-QSWTETSSNKRVYRQSHLE----------------------- 1276
                    ..||.|      .| :||   .|.|:...|.||:
pombe  1195 --------IKPVSN------RPYRSW---FSRKKDSGQKHLDNKIITESEAGPSRLELSRRILFN 1242

  Fly  1277 IDVNQKSDRMEWGHVKHHTVLQPRFAFEIVVEWVTSSGPIVADLIGGWMRKANQFNF-LVSVPAD 1340
            .||.:|:.:.|...|.:..:..|...:.|.:||:.::..::..|:..|.|...::.. ||..|..
pombe  1243 ADVEKKNGKSETVTVHYDLLHNPASCYHIRIEWLLATASVIEKLLQSWSRILERYGLKLVEAPIH 1307

  Fly  1341 PMA-----EPFTKKSDPLRGPIFIPLCTTFLPNGAALFDEFPEESRSDRMLFFQEAILGKFGFL- 1399
            .:|     .||.:.|     .|.:.|....:|..|.|.::....|::    ::...||..|.|:
pombe  1308 EIAAVGELNPFDQVS-----IISLALDPPPIPERAPLVNDPVNYSKN----WWNVKILEHFDFIL 1363

  Fly  1400 --------PCVLEKKYSVGKDLPKEYQYVHCTGNMFALIRCATNNYQVESPILKEANVTRCVYGH 1456
                    |..:...||.||...:..||:|.||.:.
pombe  1364 DTEAASTFPKSITAVYSWGKPNFRYVQYIHRTGTVL----------------------------- 1399

  Fly  1457 TNNTNVPKKVGFLWAWNHMIPNK-------KWKAQTINNSADGELFQLKMLKDFREFCSNSDQRL 1514
               ..:.....|||..|.:..:|       |....|:|.:......:|:  :.|||||||.|: |
pombe  1400 ---VQIDDDQRFLWLPNRLHNSKVSKLSFTKSNKSTLNPNLKETAEELE--RKFREFCSNKDE-L 1458

  Fly  1515 STFW 1518
            ..|:
pombe  1459 DQFY 1462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iml1	NP_728621.1	IML1	100..385	CDD:371996	103/314 (33%)
		DEP_DEPDC5-like	1122..1202	CDD:239896	14/82 (17%)
SPBC26H8.04c	NP_596645.1	DUF3608	127..425	CDD:289061	100/309 (32%)
		DEP_DEPDC5-like	1107..1189	CDD:239896	19/106 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	188	1.000	Domainoid score	I748
eggNOG	1	0.900	-	-		E1_KOG3572
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	323	1.000	Inparanoid score	I543
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005773
OrthoInspector	1	1.000	-	-		oto100463
orthoMCL	1	0.900	-	-		OOG6_103753
Panther	1	1.100	-	-	LDO	PTHR13179
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R606
SonicParanoid	1	1.000	-	-		X4166
TreeFam	0	0.000	Not matched by this tool.
	9	8.980