Protein Alignment Iml1 and T08A11.1

DIOPT Version :9

• Sequence 1: NP_728621.1
• Gene: Iml1 / 38176
• FlyBaseID: FBgn0035227
• Length: 1544
• Species: Drosophila melanogaster
• Sequence 2: NP_001366728.1
• Gene: T08A11.1 / 175548
• WormBaseID: WBGene00011604
• Length: 1712
• Species: Caenorhabditis elegans
• Alignment Length: 1789
• Identity: 431/1789 - (24%)
• Similarity: 666/1789 - (37%)
• Gaps: 584/1789 - (32%)

  Fly    66 ISIESG----IANAFKMRPYSNVVMRIVKPAD-VALDSIEITFKDQYMGRSEMWRLKTYLTDTCV 125
            :|:..|    |.|.......:::|...::..| |:||::::||::|||.|::|:|.::.|.....
 Worm   174 LSLAKGAPGLITNRIDFLKQNDIVKCTLETVDTVSLDNVQLTFREQYMSRADMYRYRSCLIGRMT 238

  Fly   126 YVNKKIDYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGD 190
            ||.:...|  |.|..::.:||.:|..|.||.:|:.|::|||||:|.|.:|:||.|||...|..||
 Worm   239 YVEEPKRY--MNINTRISDMWRKGSLVRSGYVTDKTRVVFRSSSSTVLIFIQMCSEMNQLDPQGD 301

  Fly   191 LYFEKAVNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRD--CLQQDYKGRFYE 253
            ||.||.:.|||||||.||::.||.|.|:|:|.|| :||...:|:..:....  |   |::||:|:
 Worm   302 LYLEKCIKGFLTELFLKWKEQSCTHYVSIILCSR-WYAIGGVDDAAKRFMKGAC---DHRGRYYQ 362

  Fly   254 DFYRVAIQNERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPA--TNSSATQGNFLEVLNI 316
            ||||:..|||..:||..  .||:::.........:..|:....:|..  ..|:|..||||:|:|:
 Worm   363 DFYRLLFQNEHYEDWAD--KQLKEINVGCSKYSSQIQEKLKEMLPQVQFEVSTAADGNFLQVVNM 425

  Fly   317 SLNTFEKHYLDRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAV 381
            |:|:|..::.||.|:.|||..:.:|||.||..|||:|.::||||:||.|:..|:||:||||||||
 Worm   426 SMNSFSMYHSDRRFETTGQQIIFVTPGNGVLHVDRDLVSLTKQRVIDMGISLDMVCLGEQPLHAV 490

  Fly   382 PLLKFHNKDTTLTSADDYSLPHWINLSFYSTNKKIVYS-SFIPRIKLP----------LFGSQLT 435
            ||..||.....:....:|.:|||:|.|:|...::...| .|.|||:||          :.||..|
 Worm   491 PLFVFHPIVGQMDKKCEYFIPHWMNYSYYQMARRSAISVQFRPRIQLPAAVLSAPKKMIMGSTGT 555

  Fly   436 LHDGVGDGEGEENERHFLSCNQSEYKHNSLFDYDAYDEQI------FQPLPAQSTCSLQRVVR-- 492
                            |....||..|:..  ||||  :::      .|.||.:....:..|||
 Worm   556 ----------------FRCFPQSVEKYGG--DYDA--KKLSNVCAKIQLLPKEEANDIDAVVRDA 600

  Fly   493 -------------------------AKKTSV---------------------------------- 498
                                     ..||||
 Worm   601 PEAGRRQLREILGLSPDKVKPNSDDKTKTSVRERKETDGEPSEDNNTQKAAPIASNPPPPPPLPP 665

  Fly   499 --PSLE------------------------TYA---------------------------YRNND 510
              ||:|                        ||.                           ...:.
 Worm   666 PPPSVEKKKLEPQDRDIAGSKIIKKNSESSTYGGSVRPVSAAKDIEKPAPQRSLPPLVPNAGGSS 730

  Fly   511 WENLTPTQIP--AMRRKMSDP------DIHHGTSAM--LAALQP--------DTTNLSESLASEK 557
            |.|....:.|  |....|..|      .|..|:||:  |.|..|        .||.|:
 Worm   731 WNNQNRPESPRSASYESMKMPPSSIGGSIEIGSSALTKLRATSPSRRGTIDGSTTTLA------- 788

  Fly   558 NSRRTIVSIAPIVRPGRALINPFDPSQVTIKLTSNRRRWTHIFPKGPTGVLIQQHHYQA------ 616
            |:..|.|    ..|....|||||.|....:::|:|||||.|:||...:|.....||:.:
 Worm   789 NNDLTAV----WKRQNGQLINPFRPEDFAVQVTANRRRWIHVFPVDSSGKSKLAHHFVSGQSIVH 849

  Fly   617 VPAKPTQAGQQRPLQQTQSNNNNDQEDYGCENGEQYDRVSSHSLLNKSDSSQSFVMGDEPIDFFK 681
            :...|.:  |::.:.|..|                .|.||    ::||...||     ..:...:
 Worm   850 IVGAPDE--QKKIVAQIGS----------------VDTVS----ISKSPEQQS-----SSLTRSR 887

  Fly   682 RRQNSPMNPQPANVPNLTATQAKSY---LWGATGEQEWTPAITTVKHLRPIVEGEHHHLGSLEAL 743
            |..|...:.:.::..|.....:|.|   .||:|||::|.
 Worm   888 RGANMEDDRKHSSKSNSAGNASKKYKVWAWGSTGEEKWN-------------------------- 926

  Fly   744 RALDPPPDAEAGGGRGKIIIGVDWKSLTIPACLPITTDYFPDKRSLNNDYVISDYTL------LP 802
                  .|.|         ||.|||||...|.||||||:|||.::|...:.:::|::      |.
 Worm   927 ------VDME---------IGTDWKSLVRSALLPITTDFFPDGQTLQTQFRMNEYSIEVTNKSLE 976

  Fly   803 DDVNHDYAQSRAV-------------------------------YR-------KPLSTEEVCKEI 829
            |..|..|.|....                               ||       ||...:.|.:::
 Worm   977 DYRNGLYEQDECAIIGTPFDSLEMSNSHHSDVQTTLQTQVKDQRYRRIRDRNEKPTMAQLVYEQL 1041

  Fly   830 VSQRLAQGFQLIVVD-----------------------------EKPPTASGCSSGSAVQPVKLS 865
            :.|||.:|:|::::|                             ||....||.|..|...|..:.
 Worm  1042 ILQRLQRGYQIVLLDKSLVEVSCEAAKKPSSSRPDLSRKQVTKSEKERVGSGGSERSRSNPRTIQ 1106

  Fly   866 RETNKEYLLSIGRIFHKISLSGSVITVTGYRPR-----------------------------HPY 901
               |.|.:||..:.:||::|...|:.:|.:||:                             .|:
 Worm  1107 ---NPEIVLSFNKFYHKLALEKDVVRITLFRPKAEKSDEVAGFPGWCERPSMRNEENLDEAIRPF 1168

  Fly   902 PP-----------INVDYRYRFHAPQHETYEISGVNFTTEKLENFNWNHMD-LYICTRGDVDYPL 954
            ..           .|..|.|.|..|...|||.|........|:..||:..| .:.....|:.|
 Worm  1169 KKNAHDDELNSRYFNTTYMYYFQVPDASTYEKSATKLRHHDLDKLNWSAFDSAFKNIFSDILY-- 1231

  Fly   955 MESLKYW--RYRMYLLPRENIVSKIASCQRCDIFPDVTADNTREQVEDFVRLIEAVSKLKRQYAR 1017
            .||:|.:  .:.:...|.:.:.:|:...|            |..:..:|....|..|..:..|:|
 Worm  1232 TESMKCFSASFLVVFHPTDILKTKLIEKQ------------TEGKGIEFRDPKEFESPNEAWYSR 1284

  Fly  1018 KARYLASLLQDSPIAHITKRRHSTSIISRPQPNQGLTNSPFRERVGSNRLPEKRPSINVRPKLEN 1082
            ..:.|                    ::......||:...|       |.|.:::.....:|:...
 Worm  1285 LTKLL--------------------LLMNKLQYQGMVPDP-------NSLQDRQQKWKNKPQNYK 1322

  Fly  1083 GRIPRIFPATDAAAAAGVAARDDQDDGFPVDIKFSPNATLPEIFE---AMKHPVNGVGFFSQTQS 1144
            ..:.                          |.|.:|...|....|   ::.||.|
 Worm  1323 AIVE--------------------------DFKKTPYVGLKNTNEKQMSVAHPAN---------- 1351

  Fly  1145 LPSCTFVSYDALMWLK---TRLNNGRHPLDLLEAMRKERMICHASGDWKKPVVPGFVFYYVVQQD 1206
                .||.||..:||:   ..::.....::|:..:...:.|...:...|          |..:..
 Worm  1352 ----MFVVYDFALWLRYNVEEISKFEIAVNLIRRLADSKFIQVITSKGK----------YGSESS 1402

  Fly  1207 KNAKDYAPPLDDYSAFVNEWLEIEFQGCSFLWHDEPVTTPVPNFLRDSPAPQSWTETSSNKRVYR 1271
            .|:|    .:..:.|      |..||.|.....|.|..:.|..|:......:...|..:..:...
 Worm  1403 LNSK----KMFKFKA------EYGFQLCYISDPDFPENSKVSRFMMVEYKNKICQEEETECKWQL 1457

  Fly  1272 QSHLEIDV---NQKSDRMEWGHVKHHTVLQPRFAFEIVVEWVTSSGPIVADLIGGWMRKAN-QFN 1332
            |..:::::   ...|...||..:.:.....|..||.|.::||..:|..|||.:..|..||: |..
 Worm  1458 QGDIDMELAPPTPDSPLGEWTRITYDHWFYPDTAFRITMKWVMGTGQTVADTVLSWFNKASKQGM 1522

  Fly  1333 FLVSVPADPMAEPFTKKSDPLRGPIFIPLCTTFLPNGAALFDEFPEESRSDRMLFFQEAILGKFG 1397
            .|..||.||.|......|:|||.||.|.|....:             :.||...|..: ||.:||
 Worm  1523 SLYPVPEDPFALAQDTHSNPLRCPIRIQLKEKVV-------------AHSDEREFLLK-ILFRFG 1573

  Fly  1398 FLP--CVLEKKYSVGK-----------------------------DLPKEYQYVHCTGNMFALIR 1431
            |:.  |.::..:|..:                             |:.....|:|..|.||.
 Worm  1574 FIDIGCNVKHDFSSPRTDSSSSDHTKALSSPSPTLQLEGDDGDLDDVTISMNYIHQAGGMFI--- 1635

  Fly  1432 CATNNYQVESPILKEANVTRCVYGHTNNTNVPKKVGFLWAWNHMIPNKKWKAQTINNSADGELFQ 1496
                     |.:|.|            |.|.|.  .|.|||||::.| :::.|.      .|.||
 Worm  1636 ---------SLVLSE------------NPNRPP--FFYWAWNHLLSN-RYRGQC------SEKFQ 1670

  Fly  1497 LKMLKDFREFCSNSDQRLSTFWTQSQELKRRAQK 1530
            ..:|.:||..||:.:..|:..::..:  |.:.||
 Worm  1671 DYLLSEFRAVCSDKNDTLTQLYSDFK--KEKLQK 1702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iml1	NP_728621.1	IML1	100..385	CDD:371996	126/288 (44%)
		DEP_DEPDC5-like	1122..1202	CDD:239896	14/85 (16%)
T08A11.1	NP_001366728.1	IML1	214..493	CDD:403468	125/286 (44%)
		DEP	1332..1418	CDD:214489	20/119 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164666
Domainoid	1	1.000	247	1.000	Domainoid score	I1192
eggNOG	1	0.900	-	-		E1_KOG3572
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	445	1.000	Inparanoid score	I918
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45642at2759
OrthoFinder	1	1.000	-	-		FOG0005773
OrthoInspector	1	1.000	-	-		oto19301
orthoMCL	1	0.900	-	-		OOG6_103753
Panther	1	1.100	-	-	LDO	PTHR13179
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R606
SonicParanoid	1	1.000	-	-		X4166
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.920