Protein Alignment Iml1 and depd-5

DIOPT Version :10

• Sequence 1: NP_728621.1
• Gene: Iml1 / 38176
• FlyBaseID: FBgn0035227
• Length: 1544
• Species: Drosophila melanogaster
• Sequence 2: NP_001420386.1
• Gene: depd-5 / 175548
• WormBaseID: WBGene00011604
• Length: 1718
• Species: Caenorhabditis elegans
• Alignment Length: 1799
• Identity: 429/1799 - (23%)
• Similarity: 664/1799 - (36%)
• Gaps: 598/1799 - (33%)

  Fly    66 ISIESG----IANAFKMRPYSNVVMRIVKPAD-VALDSIEITFKDQYMGRSEMWRLKTYLTDTCV 125
            :|:..|    |.|.......:::|...::..| |:||::::||::|||.|::|:|.::.|.....
 Worm   174 LSLAKGAPGLITNRIDFLKQNDIVKCTLETVDTVSLDNVQLTFREQYMSRADMYRYRSCLIGRMT 238

  Fly   126 YVNKKIDYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGD 190
            ||.:...|  |.|..::.:||.:|..|.||.:|:.|::|||||:|.|.:|:||.|||...|..||
 Worm   239 YVEEPKRY--MNINTRISDMWRKGSLVRSGYVTDKTRVVFRSSSSTVLIFIQMCSEMNQLDPQGD 301

  Fly   191 LYFEKAVNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRD--CLQQDYKGRFYE 253
            ||.||.:.|||||||.||::.||.|.|:|:|.|| :||...:|:..:....  |   |::||:|:
 Worm   302 LYLEKCIKGFLTELFLKWKEQSCTHYVSIILCSR-WYAIGGVDDAAKRFMKGAC---DHRGRYYQ 362

  Fly   254 DFYRVAIQNERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPA--TNSSATQGNFLEVLNI 316
            ||||:..|||..:||..  .||:::.........:..|:....:|..  ..|:|..||||:|:|:
 Worm   363 DFYRLLFQNEHYEDWAD--KQLKEINVGCSKYSSQIQEKLKEMLPQVQFEVSTAADGNFLQVVNM 425

  Fly   317 SLNTFEKHYLDRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAV 381
            |:|:|..::.||.|:.|||..:.:|||.||..|||:|.::||||:||.|:..|:||:||||||||
 Worm   426 SMNSFSMYHSDRRFETTGQQIIFVTPGNGVLHVDRDLVSLTKQRVIDMGISLDMVCLGEQPLHAV 490

  Fly   382 PLLKFHNKDTTLTSADDYSLPHWINLSFYSTNKKIVYS-SFIPRIKLP----------LFGSQLT 435
            ||..||.....:....:|.:|||:|.|:|...::...| .|.|||:||          :.||..|
 Worm   491 PLFVFHPIVGQMDKKCEYFIPHWMNYSYYQMARRSAISVQFRPRIQLPAAVLSAPKKMIMGSTGT 555

  Fly   436 LHDGVGDGEGEENERHFLSCNQSEYKHNSLFDYDAYDEQI------FQPLPAQSTCSLQRVVR-- 492
                            |....||..|:..  ||||  :::      .|.||.:....:..|||
 Worm   556 ----------------FRCFPQSVEKYGG--DYDA--KKLSNVCAKIQLLPKEEANDIDAVVRDA 600

  Fly   493 -------------------------AKKTSV---------------------------------- 498
                                     ..||||
 Worm   601 PEAGRRQLREILGLSPDKVKPNSDDKTKTSVRERKETDGEPSEDNNTQKAAPIASNPPPPPPLPP 665

  Fly   499 --PSLE------------------------TYA---------------------------YRNND 510
              ||:|                        ||.                           ...:.
 Worm   666 PPPSVEKKKLEPQDRDIAGSKIIKKNSESSTYGGSVRPVSAAKDIEKPAPQRSLPPLVPNAGGSS 730

  Fly   511 WENLTPTQIP--AMRRKMSDPDIHHGTSAMLAALQPDTTNLSESLASEK----NSRRTIVS---I 566
            |.|....:.|  |....|..|....|.|..:.:.....|.|..:..|.:    .|..|:.:   .
 Worm   731 WNNQNRPESPRSASYESMKMPPSSIGGSIEIGSFPAALTKLRATSPSRRGTIDGSTTTLANNDLT 795

  Fly   567 APIVRPGRALINPFDPSQVTIKLTSNRRRWTHIFPKGPTGVLIQQHHY---------------QA 616
            |...|....|||||.|....:::|:|||||.|:||...:|.....||:               |.
 Worm   796 AVWKRQNGQLINPFRPEDFAVQVTANRRRWIHVFPVDSSGKSKLAHHFVSGQSIVHIVGAPDEQK 860

  Fly   617 VPAKPTQAG-------QQRPLQQ----TQSNNNNDQEDYGCENGEQYDRVSSHSLLNKSDSSQSF 670
            ....|::.|       .:.|.||    |:|....:.||         ||  .||  :||:|:.:
 Worm   861 KIVAPSEIGSVDTVSISKSPEQQSSSLTRSRRGANMED---------DR--KHS--SKSNSAGN- 911

  Fly   671 VMGDEPIDFFKRRQNSPMNPQPANVPNLTATQAKSYLWGATGEQEWTPAITTVKHLRPIVEGEHH 735
                                        .:.:.|.:.||:|||::|.
 Worm   912 ----------------------------ASKKYKVWAWGSTGEEKWN------------------ 930

  Fly   736 HLGSLEALRALDPPPDAEAGGGRGKIIIGVDWKSLTIPACLPITTDYFPDKRSLNNDYVISDYTL 800
                          .|.|         ||.|||||...|.||||||:|||.::|...:.:::|::
 Worm   931 --------------VDME---------IGTDWKSLVRSALLPITTDFFPDGQTLQTQFRMNEYSI 972

  Fly   801 ------LPDDVNHDYAQSRAV-------------------------------YR-------KPLS 821
                  |.|..|..|.|....                               ||       ||..
 Worm   973 EVTNKSLEDYRNGLYEQDECAIIGTPFDSLEMSNSHHSDVQTTLQTQVKDQRYRRIRDRNEKPTM 1037

  Fly   822 TEEVCKEIVSQRLAQGFQLIVVD-----------------------------EKPPTASGCSSGS 857
            .:.|.::::.|||.:|:|::::|                             ||....||.|..|
 Worm  1038 AQLVYEQLILQRLQRGYQIVLLDKSLVEVSCEAAKKPSSSRPDLSRKQVTKSEKERVGSGGSERS 1102

  Fly   858 AVQPVKLSRETNKEYLLSIGRIFHKISLSGSVITVTGYRPR------------------------ 898
            ...|..:.   |.|.:||..:.:||::|...|:.:|.:||:
 Worm  1103 RSNPRTIQ---NPEIVLSFNKFYHKLALEKDVVRITLFRPKAEKSDEVAGFPGWCERPSMRNEEN 1164

  Fly   899 -----HPYPP-----------INVDYRYRFHAPQHETYEISGVNFTTEKLENFNWNHMD-LYICT 946
                 .|:..           .|..|.|.|..|...|||.|........|:..||:..| .:...
 Worm  1165 LDEAIRPFKKNAHDDELNSRYFNTTYMYYFQVPDASTYEKSATKLRHHDLDKLNWSAFDSAFKNI 1229

  Fly   947 RGDVDYPLMESLKYW--RYRMYLLPRENIVSKIASCQRCDIFPDVTADNTREQVEDFVRLIEAVS 1009
            ..|:.|  .||:|.:  .:.:...|.:.:.:|:...|            |..:..:|....|..|
 Worm  1230 FSDILY--TESMKCFSASFLVVFHPTDILKTKLIEKQ------------TEGKGIEFRDPKEFES 1280

  Fly  1010 KLKRQYARKARYLASLLQDSPIAHITKRRHSTSIISRPQPNQGLTNSPFRERVGSNRLPEKRPSI 1074
            ..:..|:|..:.|                    ::......||:...|       |.|.:::...
 Worm  1281 PNEAWYSRLTKLL--------------------LLMNKLQYQGMVPDP-------NSLQDRQQKW 1318

  Fly  1075 NVRPKLENGRIPRIFPATDAAAAAGVAARDDQDDGFPVDIKFSPNATLPEIFE---AMKHPVNGV 1136
            ..:|:.....:.                          |.|.:|...|....|   ::.||.|
 Worm  1319 KNKPQNYKAIVE--------------------------DFKKTPYVGLKNTNEKQMSVAHPAN-- 1355

  Fly  1137 GFFSQTQSLPSCTFVSYDALMWLK---TRLNNGRHPLDLLEAMRKERMI--CHASGDWKKPVVPG 1196
                        .||.||..:||:   ..::.....::|:..:...:.|  ..:|.:.|
 Worm  1356 ------------MFVVYDFALWLRYNVEEISKFEIAVNLIRRLADSKFIQVITSSSEGK------ 1402

  Fly  1197 FVFYYVVQQDKNAKDYAPPLDDYSAFVNEWLEIEFQGCSFLWHDEPVTTPVPNFLRDSPAPQSWT 1261
                |..:...|:|    .:..:.|      |..||.|.....|.|..:.|..|:......:...
 Worm  1403 ----YGSESSLNSK----KMFKFKA------EYGFQLCYISDPDFPENSKVSRFMMVEYKNKICQ 1453

  Fly  1262 ETSSNKRVYRQSHLEIDV---NQKSDRMEWGHVKHHTVLQPRFAFEIVVEWVTSSGPIVADLIGG 1323
            |..:..:...|..:::::   ...|...||..:.:.....|..||.|.::||..:|..|||.:..
 Worm  1454 EEETECKWQLQGDIDMELAPPTPDSPLGEWTRITYDHWFYPDTAFRITMKWVMGTGQTVADTVLS 1518

  Fly  1324 WMRKAN-QFNFLVSVPADPMAEPFTKKSDPLRGPIFIPLCTTFLPNGAALFDEFPEESRSDRMLF 1387
            |..||: |...|..||.||.|......|:|||.||.|.|....:             :.||...|
 Worm  1519 WFNKASKQGMSLYPVPEDPFALAQDTHSNPLRCPIRIQLKEKVV-------------AHSDEREF 1570

  Fly  1388 FQEAILGKFGFLP--CVLEKKYSVGK-----------------------------DLPKEYQYVH 1421
            ..: ||.:|||:.  |.::..:|..:                             |:.....|:|
 Worm  1571 LLK-ILFRFGFIDIGCNVKHDFSSPRTDSSSSDHTKALSSPSPTLQLEGDDGDLDDVTISMNYIH 1634

  Fly  1422 CTGNMFALIRCATNNYQVESPILKEANVTRCVYGHTNNTNVPKKVGFLWAWNHMIPNKKWKAQTI 1486
            ..|.||.            |.:|.|            |.|.|.  .|.|||||::.| :::.|.
 Worm  1635 QAGGMFI------------SLVLSE------------NPNRPP--FFYWAWNHLLSN-RYRGQC- 1671

  Fly  1487 NNSADGELFQLKMLKDFREFCSNSDQRLSTFWTQSQELKRRAQK 1530
                 .|.||..:|.:||..||:.:..|:..::..:  |.:.||
 Worm  1672 -----SEKFQDYLLSEFRAVCSDKNDTLTQLYSDFK--KEKLQK 1708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iml1	NP_728621.1	IML1	100..385	CDD:463510	126/288 (44%)
		DEP_DEPDC5-like	1122..1202	CDD:239896	15/87 (17%)
		DEPDC5_CTD	1216..1511	CDD:466071	80/329 (24%)
depd-5	NP_001420386.1	IML1	214..493	CDD:463510	125/286 (44%)
		DEP	1336..1424	CDD:214489	21/121 (17%)
		DEPDC5_CTD	<1482..1692	CDD:466071	68/256 (27%)