Protein Alignment Iml1 and depdc5

DIOPT Version :9

• Sequence 1: NP_728621.1
• Gene: Iml1 / 38176
• FlyBaseID: FBgn0035227
• Length: 1544
• Species: Drosophila melanogaster
• Sequence 2: XP_004910648.1
• Gene: depdc5 / 100498286
• XenbaseID: XB-GENE-980707
• Length: 1608
• Species: Xenopus tropicalis
• Alignment Length: 1730
• Identity: 590/1730 - (34%)
• Similarity: 856/1730 - (49%)
• Gaps: 366/1730 - (21%)

  Fly     2 KLYKLNTHTRGCNKSYDADLVMNLKDHPNANVGDVVEIYAPDEENGTHLLLQITEFNGSCGRDVI 66
            ::|||..|.:|...| |.:||:|.|..|..|:||:|||..|::|. :.||||:........::.:
 Frog    30 RVYKLVIHKKGFGGS-DDELVINPKVFPYINLGDIVEIAHPNDEY-SPLLLQVKSLKEDLQKETV 92

  Fly    67 SIESGIANAFKMRPYSNVVMRIVKPADVALDSIEITFKDQYMGRSEMWRLKTYLTDTCVYVNKKI 131
            ||:..:|..|::|||.:|.:.:|.|.||.||.:|:||||||:||.:|||||..|..:|.|:.:|:
 Frog    93 SIDQTVAQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSSCAYITQKV 157

  Fly   132 DYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWDFDIHGDLYFEKA 196
            ::  ..||.||.|:|.:.|:|..|.|:|||::||||:::|||:|:|||||:|||||:||||||||
 Frog   158 EF--AGIRAQVGELWVKSEKVTCGYISEDTRVVFRSTSAMVYIFIQMSSELWDFDIYGDLYFEKA 220

  Fly   197 VNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPE-HMRDCLQQDYKGRFYEDFYRVAI 260
            |||||.:||.||:..:|:||||:||||||||.||::::||| |....:.||:|||||||||:|.:
 Frog   221 VNGFLADLFNKWKDKNCSHEVTVVLFSRTFYDAKNIEDFPEAHRNASVMQDHKGRFYEDFYKVVV 285

  Fly   261 QNERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPATNSSATQGNFLEVLNISLNTFEKHY 325
            ||||.::|.::|..::|||..|...| |....|.  .||..||::.|||:||.:|:|.|.|:|||
 Frog   286 QNERREEWTSLLVTIKKLFIQYPVLV-RLENAEG--FPPGHNSTSDQGNYLEAINLSFNVFDKHY 347

  Fly   326 LDRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDNGVGSDLVCVGEQPLHAVPLLKFHNKD 390
            ::|.||||||:|||||||||||.|||.|..:||||:||||:|.||||:||||||||||.|.||:.
 Frog   348 INRNFDRTGQMSVVITPGVGVFQVDRSLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRS 412

  Fly   391 TTLTS--ADDYSLPHWINLSFYSTNKKIVYSSFIPRIKL---------------PLFGSQLTLHD 438
            :...|  .|||::|||||.|||::..:.:.:||.|||||               |..||.
 Frog   413 SPGDSRLGDDYNIPHWINHSFYTSQSQPLNNSFTPRIKLAPRKTNSEKGRTGKDPSIGSP----- 472

  Fly   439 GVGDGEGEENERHFLSCNQSEYKHNSL---FDYDAYDEQIFQ-PLPAQSTCSLQ-RVVR---AKK 495
                   :|.|             |:|   .||||||.|:|: |.|:::..|:. |.||   .:|
 Frog   473 -------KETE-------------NALPIQVDYDAYDSQVFRLPGPSRAQRSITFRAVRETQVRK 517

  Fly   496 TSVP------------SLETYAYRNNDWENLTPTQIPAMRRKMSD------PDIHHGTSAMLAAL 542
            :|..            :.|....:|:|..:|         .|:|:      |.:|...::.....
 Frog   518 SSCSYDTSCSPVSRPFTAEEGRSQNSDESSL---------GKLSNILLIPRPHLHQYEASSSLGY 573

  Fly   543 QPDTTNLSESLASEKNSRRTIVSIAP------------IVRPG-----RALINPFDPSQVTIKLT 590
            ......|...:.|::..     |.||            .||||     |||||||.||::.:|||
 Frog   574 TSTRDFLERMIESQQRD-----SSAPGRFHVGSAESMLHVRPGGYHPQRALINPFAPSRMPMKLT 633

  Fly   591 SNRRRWTHIFPKGPTGVLIQQHHYQAVPAKPTQAGQQRPLQQTQSNNNNDQEDYGCENGEQYDRV 655
            ||||||.|.||.||:|..||.||                  ||:.|....|       |... |.
 Frog   634 SNRRRWMHTFPVGPSGEAIQIHH------------------QTRQNMAELQ-------GSGM-RE 672

  Fly   656 SSHSLLNKSDSSQSFVMGDEPIDFFKRRQNSPMNPQPANVPNLTATQAKSYLWGATGEQEWTPAI 720
            :|||.....:.:.....|         |.:.|..|...               |:.|..|.....
 Frog   673 ASHSSAELLELAYHEATG---------RHSGPRTPGEN---------------GSCGSNEEFSCN 713

  Fly   721 TTVKHLRPIVEGEHHHLGS---------------LEALRALDPPPDAEAGGGRGKII------IG 764
            |      ||....:|:.||               .|.:..|..||          ::      :|
 Frog   714 T------PINGQRNHNTGSNHREKESSDDSVPCCPEPILMLSAPP----------VVPGFCCTVG 762

  Fly   765 VDWKSLTIPACLPITTDYFPDKRSLNNDYVISDYTLLP----DDVNHDYAQSRAVYRKPLSTEEV 825
            |||||||.|||||:|||||||::||.|||....|.|||    |..:.:.||        ::.::|
 Frog   763 VDWKSLTTPACLPLTTDYFPDRQSLQNDYTEGCYDLLPEADLDRRDEEGAQ--------MTAQQV 819

  Fly   826 CKEIVSQRLAQGFQLIVVDEKPPTASG----CSSGSAVQPVKLSR---ETNKEYLLSIGRIFHKI 883
            .:|.:.|||.||:|:||..:.|...|.    .||....:...:||   |...:|.||:||.|||:
 Frog   820 FEEFICQRLMQGYQIIVQPKHPKAISSVPPPLSSSPLYRRGLVSRNRAEEENQYWLSMGRTFHKV 884

  Fly   884 SLSGSVITVTGYRPRHPYPPINVDYRYRFHAPQHETYEI--SGVNFTTEKLENFNWNHMDLYICT 946
            :|...:||||.|.|::||....:.|.|.. .|.|...:.  |.|.|:.|:||::.||::|.|||:
 Frog   885 TLKDKIITVTRYLPKYPYESAQISYMYSL-CPSHSECDFVSSWVEFSHERLEDYKWNYLDQYICS 948

  Fly   947 RGDVDYPLMESLKYWRYRMYLLPRENIVSKIASC-----------QRCDIFPDVTADNTREQ--V 998
            .|..|:.|:||||:||.|..|||         ||           |||||:.:.......|.  :
 Frog   949 AGSEDFSLIESLKFWRTRFLLLP---------SCVGPTKRITEGEQRCDIYGERPRSEQEEAQLL 1004

  Fly   999 EDFVRLIEAVSKLKRQYARKARYL----------------------------------------- 1022
            :.|:|.:|.:::::|:: |..|.:
 Frog  1005 DGFLRFVEGLNRIRRRH-RSDRMIRKGAGMKGLQLPSHPPEPPGPPIGKKGTSALSALLEMEANQ 1068

  Fly  1023 ASLLQDSPIAHITKRRHSTSIISRPQPNQGLTNSP------FRERVGSNR-LPEKRPSINVRPKL 1080
            .||.:...:.|..|   .:|.:|.|.......:||      |.|.|.|.| .|...|.|::....
 Frog  1069 KSLGEQQALVHAAK---LSSQVSDPAVTPTYVDSPRKDGAFFVEFVRSPRTAPSFTPQISIDQGT 1130

  Fly  1081 E-----NGRIPRIFPA--TDAAAAAGVAARDDQDDGFPVDIKFSPN-----ATLPEIFEAMKHPV 1133
            .     |..:|...|:  ..:..|..|.......:.....|...|:     |:|.||.||||||.
 Frog  1131 SLVTDGNNAMPNPTPSERIQSQGATSVDQPPTSTECSAQQISVGPSVLPTTASLSEILEAMKHPT 1195

  Fly  1134 NGVGFFSQTQSLPSCTFVSYDALMWLKTRLN---NGRHPLDLLEAMRKERMICHASGDWKKPVVP 1195
            .|:...|:.:.||...|:|.:|:.||...::   :....:|:::.|.:|:.|.||||:..:..:.
 Frog  1196 TGIPLLSEQKCLPPGCFISAEAVHWLVNNISWVQSQVMAMDIMQKMLEEQYITHASGETFRTFIY 1260

  Fly  1196 GFVFYYVVQQDK---NAKDYAPP-------LDDYSAFVNEWLEIEFQGCSFLWHDEPVTTPVPNF 1250
            || :.|.:..||   .|.:...|       ::|::||..:|.|:.      |..:|.:.:.:|.|
 Frog  1261 GF-YLYKIPADKEPDRASNLVQPCVWHSTAMEDFTAFQRKWFEVA------LVEEELLHSEIPPF 1318

  Fly  1251 ----LRDSPAPQSWTETSSNKRVYRQSH----------------LEIDVNQKSDRMEWGHVKHHT 1295
                |...||..:...:|.::....:|.                |::|||.::||:||....:|.
 Frog  1319 LLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSSYYHG 1383

  Fly  1296 VLQPRFAFEIVVEWVTSSGPIVADLIGGWMRKANQFNF-LVSVPADPMAEPFTKKSDPLRGPIFI 1359
            ......||||.:.|:.::..::.:::.||.|||....| ||.|...|.:.|.....||||..:||
 Frog  1384 NFSLTAAFEIKLHWMAATAAMLFEMVQGWHRKAPSCGFLLVPVVEGPFSLPSYLYGDPLRAQLFI 1448

  Fly  1360 PL---CTTFLPNGAALFDEFPEESRSDRMLFFQEAILGKFGFLPCVLEKKYSVGK-DLPKEY--Q 1418
            ||   |.....|. .||:.|..|:..:||...||.|..:|||    ::.|||... :.|.|.  |
 Frog  1449 PLNISCLVKAEND-HLFEGFEPETYWERMYLLQEVIAYRFGF----IQDKYSASAFNFPSENKPQ 1508

  Fly  1419 YVHCTGNMFALIRCATNNYQVESPILKEANVTRCVYGHTNNTNVPKKVGFLWAWNHMIPNKKWKA 1483
            |:|.||.:|..:..:....|........::.|:.::|.       :::|:.||:|.|: .|.|:
 Frog  1509 YIHVTGTVFLQLPYSKRKGQQRRRRNSTSSSTQNLFGE-------ERIGYNWAYNTML-TKTWR- 1564

  Fly  1484 QTINNSADGELFQLKMLKDFREFCSNSDQRLSTFWTQSQE 1523
               :.....|.|..::||||.:||:|.|.||.|||....|
 Frog  1565 ---SIGTGDERFADRLLKDFTDFCANRDNRLGTFWANCLE 1601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Iml1	NP_728621.1	IML1	100..385	CDD:371996	171/285 (60%)
		DEP_DEPDC5-like	1122..1202	CDD:239896	28/82 (34%)
depdc5	XP_004910648.1	IML1	126..407	CDD:371996	171/285 (60%)
		DEP_DEPDC5-like	1184..1267	CDD:239896	29/83 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I892
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H34718
Inparanoid	1	1.050	869	1.000	Inparanoid score	I412
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45642at2759
OrthoFinder	1	1.000	-	-		FOG0005773
OrthoInspector	1	1.000	-	-		oto102298
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4166
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060