Protein Alignment Psa and NPEPPS

DIOPT Version :10

• Sequence 1: NP_728614.1
• Gene: Psa / 38175
• FlyBaseID: FBgn0261243
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_001398059.1
• Gene: NPEPPS / 9520
• HGNCID: 7900
• Length: 924
• Species: Homo sapiens
• Alignment Length: 840
• Identity: 472/840 - (56%)
• Similarity: 595/840 - (70%)
• Gaps: 36/840 - (4%)

  Fly   191 RRAHTQLLSKEQQLEQERKMAQKAKFERLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPT 255
            ||.|:..|:         .|.:|..|||||.:|.|.:|.|.|:|:|.:|||.||......|::.|
Human    35 RRLHSLGLA---------AMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQAT 90

  Fly   256 TQITLNALDIVLDSV--------ELH---FECSKLKPEKIVYSAENETATLEFAQEIPAETQGVL 309
            .||.:|..||.:.:.        |:|   |.          |..|:|..||.|...:...| |.|
Human    91 NQIVMNCADIDIITASYAPEGDEEIHATGFN----------YQNEDEKVTLSFPSTLQTGT-GTL 144

  Fly   310 HMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKD 374
            .:.|.|||||||||||||||..|:||.|:|.|||||||||||.|||||||||||||||:||||||
Human   145 KIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKD 209

  Fly   375 RVALSNMPVIKEDSLPD--GLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGK 437
            |||||||.||.....||  .|..|:|.|||:|||||||.||||||:||.:|.|||.|||:|||||
Human   210 RVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGK 274

  Fly   438 REQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTS 502
            .|||.||||||.|.||:||||||:.|||||:|||||:||:|||||||||||||||.:|:||||:.
Human   275 AEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSC 339

  Fly   503 LMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMY 567
            ...:|.:||.||||:||||||||||||||||||||||:||::|:|||.|.|||||||||||:..|
Human   340 SSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADY 404

  Fly   568 TRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQ 632
            |||.|||:|.|||||||.||||||:|||||.|||:||||||||||||||:..|:||||:|||:.|
Human   405 TRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQ 469

  Fly   633 YGNTCTEDLWAALQEASSKNVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQA 697
            ..|..|||||.:|:.||.|.::.||.:||:..|||::.||:||. ::.|||||.|.||.|.||..
Human   470 QKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQV-EDDRLLRLSQKKFCAGGSYV 533

  Fly   698 DENC-LWVVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEML 761
            .|:| .|:|||::|||::|.......|:||..|.|.|.||..|.|:|:|.||||:|||:||..||
Human   534 GEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAML 598

  Fly   762 EQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLH 826
            |.|:|.:..:.|||:|||||.:|:|::.:||..||.:||.:::::.||.|||||:.::.:|..|.
Human   599 ESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILS 663

  Fly   827 ILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIR 891
            .|:||||..|:...|.::::.|:..||||:|:.||.|||.|||.|||.:|.......|:|||:.|
Human   664 TLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRR 728

  Fly   892 FRRHVNGTELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLR 956
            |:.||.|.::|.||||:..|..||:.||....:.||.|::..|:.||::||.|.||......|::
Human   729 FKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQ 793

  Fly   957 RVIDFAMSSEVRAQDSVFVIVAVAINPK-GRDMAWEFFKENNKQLLERYQGGFLLSRLIK 1015
            :|:.||:|.|||.||:|.||..||...| ||..||:|.|:|.::|..|||||||:|||||
Human   794 KVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIK 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	M1_APN-Q_like	227..662	CDD:341064	288/447 (64%)
		ERAP1_C	741..1055	CDD:463368	133/276 (48%)
NPEPPS	NP_001398059.1	M1_APN-Q_like	61..499	CDD:341064	288/448 (64%)
		ERAP1_C	578..854	CDD:463368	133/276 (48%)
		Nuclear localization signal. /evidence=ECO:0000255	726..730		1/3 (33%)