Protein Alignment Psa and AAP1

DIOPT Version :10

• Sequence 1: NP_728614.1
• Gene: Psa / 38175
• FlyBaseID: FBgn0261243
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 881
• Identity: 327/881 - (37%)
• Similarity: 510/881 - (57%)
• Gaps: 53/881 - (6%)

  Fly   217 ERLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKLKP 281
            |.||.||.|.||::.|:||.:.|||.|...:.:.:.:.    ::|::.|  :.:|:.|..::::.
Yeast     4 EVLPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDH----SINSVQI--NYLEIDFHSARIEG 62

  Fly   282 EKIVYSAENET---ATLEFAQEIPAET------QGVLHMSFTGELNDKMKGFYRSKYFGP-NGEE 336
            ...:...:||.   |||.|    |..|      ...|.:.|:|.|||:|.||||:||... .||.
Yeast    63 VNAIEVNKNENQQKATLVF----PNGTFENLGPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGET 123

  Fly   337 RFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRT 401
            ::...||.|||||||.|||:|||.:||||.:|||.......||||.| :.:::.:|.:...|:.|
Yeast   124 KYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDV-RNETIKEGKKYTTFNTT 187

  Fly   402 PIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLP 466
            |.|||||||.:|.:..||| .::..:.|||::..|..:.|.||..:|.:.|.:::|.|||.||||
Yeast   188 PKMSTYLVAFIVADLRYVE-SNNFRIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTFNIEYPLP 251

  Fly   467 KMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWW 531
            |||::|:.:|||||||||||||||...:|:|.:|:||.|.|.:|..:.||:|||||||||||:||
Yeast   252 KMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWW 316

  Fly   532 THLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIF 596
            ..||||||:|:::.:...:...||:.:|.|:|||...|||.||||::||||||||.:..||::||
Yeast   317 EGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEINQIF 381

  Fly   597 DEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSKNVSDVMTSWT 661
            |.|||:||:|::||:..::||:||.||::.||.:.:|||..|.|||.||.:||.|:|..||..||
Yeast   382 DAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGKDVCSVMNIWT 446

  Fly   662 QHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVSTSKNPTGIAKTFLLDK 726
            :..||||:||:..   ||:  :.|.|.::.:.|...:|....:.||.::. |:.|||..|.:|::
Yeast   447 KRVGFPVLSVKEH---KNK--ITLTQHRYLSTGDVKEEEDTTIYPILLAL-KDSTGIDNTLVLNE 505

  Fly   727 SSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEKMELPPLDRLGLIDDMFAMVQA 791
            .|....|.|   :::.|||....|.:.|.||.|...:|......:.:.  ||:||:.|..|:..:
Yeast   506 KSATFELKN---EEFFKINGDQSGIFITSYSDERWAKLSKQANLLSVE--DRVGLVADAKALSAS 565

  Fly   792 GHASTADVLALVDSYRNETNYTVWTAITNSLTNLHI--LISHTDLMEDFHRFGRNLYEPVAYRLG 854
            |:.||.:.|.|:.:::||.::.||..|.|||:.|..  :....|::....:|..:|.......||
Yeast   566 GYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELG 630

  Fly   855 WEPRDGENHLDTLLRSLVLTRL--VSFRSSDTIEEAKIR------FRRHVNGT-ELLPADLRTTC 910
            |  ..||:.      |..:.||  ..|.::.|....|::      |..:.||. :.:||..:...
Yeast   631 W--NIGEDD------SFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYANGNKQAIPALFKAVV 687

  Fly   911 YKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSEVRAQDSVFV 975
            :..|.:.|.|..:.::.::|:.....||:....||||...|.:||.|.:.:.:...|..||....
Yeast   688 FNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLDGTVLNQDFYIP 752

  Fly   976 IVAVAINPKGRDMAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIENFASEERAKEVEEFLQVNQI 1039
            :..:.::.||.:..|.:.:|:..::.:|.| |..:|..::...:.||.|.|..:::..|......
Yeast   753 MQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYSRKVT 817

  Fly  1040 PGCERTVSQAVETIRLNAAWLQRDREQLAIFLRDDQ 1075
            .|.::|::||::|||..|.|:.||||.:|.:||:.:
Yeast   818 KGFDQTLAQALDTIRSKAQWVSRDREIVATYLREHE 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	M1_APN-Q_like	227..662	CDD:341064	203/444 (46%)
		ERAP1_C	741..1055	CDD:463368	84/325 (26%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	203/445 (46%)
		ERAP1_C	517..833	CDD:463368	84/325 (26%)