DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and AAP1

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_011913.1	Gene:	AAP1 / 856443	SGDID:	S000001089	Length:	856	Species:	Saccharomyces cerevisiae

Alignment Length:	881	Identity:	327/881 - (37%)
Similarity:	510/881 - (57%)	Gaps:	53/881 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 ERLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKLKP 281
            |.||.||.|.||::.|:||.:.|||.|...:.:.:.:.    ::|::.|  :.:|:.|..::::.
Yeast     4 EVLPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDH----SINSVQI--NYLEIDFHSARIEG 62

  Fly   282 EKIVYSAENET---ATLEFAQEIPAET------QGVLHMSFTGELNDKMKGFYRSKYFGP-NGEE 336
            ...:...:||.   |||.|    |..|      ...|.:.|:|.|||:|.||||:||... .||.
Yeast    63 VNAIEVNKNENQQKATLVF----PNGTFENLGPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGET 123

  Fly   337 RFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRT 401
            ::...||.|||||||.|||:|||.:||||.:|||.......||||.| :.:::.:|.:...|:.|
Yeast   124 KYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDV-RNETIKEGKKYTTFNTT 187

  Fly   402 PIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLP 466
            |.|||||||.:|.:..||| .::..:.|||::..|..:.|.||..:|.:.|.:::|.|||.||||
Yeast   188 PKMSTYLVAFIVADLRYVE-SNNFRIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTFNIEYPLP 251

  Fly   467 KMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWW 531
            |||::|:.:|||||||||||||||...:|:|.:|:||.|.|.:|..:.||:|||||||||||:||
Yeast   252 KMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWW 316

  Fly   532 THLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIF 596
            ..||||||:|:::.:...:...||:.:|.|:|||...|||.||||::||||||||.:..||::||
Yeast   317 EGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEINQIF 381

  Fly   597 DEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSKNVSDVMTSWT 661
            |.|||:||:|::||:..::||:||.||::.||.:.:|||..|.|||.||.:||.|:|..||..||
Yeast   382 DAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGKDVCSVMNIWT 446

  Fly   662 QHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVSTSKNPTGIAKTFLLDK 726
            :..||||:||:..   ||:  :.|.|.::.:.|...:|....:.||.::. |:.|||..|.:|::
Yeast   447 KRVGFPVLSVKEH---KNK--ITLTQHRYLSTGDVKEEEDTTIYPILLAL-KDSTGIDNTLVLNE 505

  Fly   727 SSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEKMELPPLDRLGLIDDMFAMVQA 791
            .|....|.|   :::.|||....|.:.|.||.|...:|......:.:.  ||:||:.|..|:..:
Yeast   506 KSATFELKN---EEFFKINGDQSGIFITSYSDERWAKLSKQANLLSVE--DRVGLVADAKALSAS 565

  Fly   792 GHASTADVLALVDSYRNETNYTVWTAITNSLTNLHI--LISHTDLMEDFHRFGRNLYEPVAYRLG 854
            |:.||.:.|.|:.:::||.::.||..|.|||:.|..  :....|::....:|..:|.......||
Yeast   566 GYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELG 630

  Fly   855 WEPRDGENHLDTLLRSLVLTRL--VSFRSSDTIEEAKIR------FRRHVNGT-ELLPADLRTTC 910
            |  ..||:.      |..:.||  ..|.::.|....|::      |..:.||. :.:||..:...
Yeast   631 W--NIGEDD------SFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYANGNKQAIPALFKAVV 687

  Fly   911 YKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSEVRAQDSVFV 975
            :..|.:.|.|..:.::.::|:.....||:....||||...|.:||.|.:.:.:...|..||....
Yeast   688 FNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLDGTVLNQDFYIP 752

  Fly   976 IVAVAINPKGRDMAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIENFASEERAKEVEEFLQVNQI 1039
            :..:.::.||.:..|.:.:|:..::.:|.| |..:|..::...:.||.|.|..:::..|......
Yeast   753 MQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYSRKVT 817

  Fly  1040 PGCERTVSQAVETIRLNAAWLQRDREQLAIFLRDDQ 1075
            .|.::|::||::|||..|.|:.||||.:|.:||:.:
Yeast   818 KGFDQTLAQALDTIRSKAQWVSRDREIVATYLREHE 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	179/395 (45%)
		M1_APN_2	227..667	CDD:189008	205/449 (46%)
		ERAP1_C	742..1052	CDD:288671	82/321 (26%)
AAP1	NP_011913.1	PepN	2..844	CDD:223385	323/870 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345496
Domainoid	1	1.000	264	1.000	Domainoid score	I296
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I167
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	1	1.010	-	-		QHG53945
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm46696
orthoMCL	1	0.900	-	-		OOG6_100948
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2032
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	13	12.680