Protein Alignment Psa and LAP2

DIOPT Version :10

• Sequence 1: NP_728614.1
• Gene: Psa / 38175
• FlyBaseID: FBgn0261243
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_014353.1
• Gene: LAP2 / 855682
• SGDID: S000004990
• Length: 671
• Species: Saccharomyces cerevisiae
• Alignment Length: 749
• Identity: 144/749 - (19%)
• Similarity: 256/749 - (34%)
• Gaps: 243/749 - (32%)

  Fly   174 VIPGQDRHHPGCNYQQIR-RAHTQLLSKEQQLEQERKMAQKAKFERLPT--------------NV 223
            ::|...||........:| |....::|:...:....||...:..:|.|:              :.
Yeast     3 LLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLSIEQRRPSRSPEYDQSTLSNYKDF 67

  Fly   224 VPRHYELLLQPNLKEFTFTGKTVVQVNV----KEPTTQITLNALDIVLDSVELHFECSK------ 278
            ...|.:|.|..:.::...:|....|:..    |..:.::.|:.  ..||..|:|.:.||
Yeast    68 AVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDT--SYLDVQEVHIDGSKADFQIE 130

  Fly   279 -----LKPEKIVYSA---ENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGE 335
                 |....::.:|   :|.|..::|     ..|.....:.:   ||.|.....:...|
Yeast   131 QRKEPLGSRLVINNASCNDNFTLNIQF-----RTTDKCTALQW---LNSKQTKGGKPYVF----- 182

  Fly   336 ERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVI-----KEDSLPDGLRR 395
                  :|.||..||..|||:|.|::|:||..::..|        :||:     .||:..| ...
Yeast   183 ------SQLEAIHARSLFPCFDTPSVKSTFTASIESP--------LPVVFSGIRIEDTSKD-TNI 232

  Fly   396 VRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKRE------------QGTFA---- 444
            .||::...:..||:.:..|:..              ..|:|.|.            |..|.
Yeast   233 YRFEQKVPIPAYLIGIASGDLS--------------SAPIGPRSTVYTEPFRLKDCQWEFENDVE 283

  Fly   445 --LEVATKVLPYYK-DYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRK 506
              ::.|.|::..|: ..::|        |:.:..:..|.||:..:.....|.:..|..|..:
Yeast   284 KFIQTAEKIIFEYEWGTYDI--------LVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDV--- 337

  Fly   507 QSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHL-------FPEYDIWTQFVT 564
                  :.||:||.|.|||||...|.|.|||||:..::|...:..:       |.....|:....
Yeast   338 ------IAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQN 396

  Fly   565 DMYTRALELDSLKNSHPIEVPV---GHPSEIDEIFDEISYNKGASVIRMLHDYIG---------E 617
                   .:||:|:.......|   ...::.|:.|..:.|.||.:::..|...:|         .
Yeast   397 -------SIDSMKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIR 454

  Fly   618 DTFRKGMNLYLTRHQYGNTCTE--------------DLW-------------AALQEASSKNVSD 655
            ..|:|.....|...|:.:|..|              :.|             .||.:    ||..
Yeast   455 HYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETWLYKPGMPPRPHFITALAD----NVYQ 515

  Fly   656 VMTSW---TQH--------KGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISV 709
            :...|   .||        ..|..:.:  :..:.||.:|.|:........::..::..|
Yeast   516 LADKWVEMAQHLKTTEDFRSEFNAIDI--KDFNSNQLVLFLETLTQNGHSNKKPKDFDW------ 572

  Fly   710 STSKNPTGIAKTFLLDKSSMEVTLDNVDED--------------------------DWIKINPGT 748
              :|.|  :|...|||     :..||:.:.                          ||:    ||
Yeast   573 --AKFP--VASRALLD-----IYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWL----GT 624

  Fly   749 VG---YYRTRYSQEMLEQLMPAVE-KMELPPLDR 778
            ||   :.|..|      :|:.:|: ::.|...|:
Yeast   625 VGRMKFVRPGY------RLLNSVDRRLALATFDK 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	M1_APN-Q_like	227..662	CDD:341064	106/525 (20%)
		ERAP1_C	741..1055	CDD:463368	11/42 (26%)
LAP2	NP_014353.1	leuko_A4_hydro	57..669	CDD:274120	134/695 (19%)