Protein Alignment Psa and TMA108

DIOPT Version :10

• Sequence 1: NP_728614.1
• Gene: Psa / 38175
• FlyBaseID: FBgn0261243
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_012129.1
• Gene: TMA108 / 854669
• SGDID: S000001399
• Length: 946
• Species: Saccharomyces cerevisiae
• Alignment Length: 988
• Identity: 227/988 - (22%)
• Similarity: 404/988 - (40%)
• Gaps: 187/988 - (18%)

  Fly   219 LPTNVVPRHYELLLQ-------PNLK-----EFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVE 271
            |...|||.||||.|:       ||.|     ...|...:....::::..||..|::.|:::.|..
Yeast     8 LENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAH 72

  Fly   272 LHFECSK--LKPEKIV---YSAENETATLEFAQEIPAETQGVLHMSFTGEL------NDKMKGFY 325
            .....:|  ||..:..   .|..|..:.::.:.:.|.    :|.:.:.|::      :||..|.:
Yeast    73 ATIGSTKFDLKISQDTGKHLSIFNSESPIQLSNDCPL----ILSVQYVGKIRDIKTHHDKTFGIF 133

  Fly   326 RSKYFGPNGEERFAG-------VTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPV 383
            ::.:.     :|..|       .|..:...|...|||.|||:.|:||.:.:.......|:||.||
Yeast   134 KTNFM-----DRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPV 193

  Fly   384 IKEDSLPDGLRR-VRFDRTPIMSTYLVAVVVGEYDY----VEGKSDDGVLVRVFTPVGKREQGTF 443
            ...::|....:. |:|.:||:|:|.:....:|:.::    ::.:.|..:.|.::.| .......|
Yeast   194 EMVEALDSSQKHLVKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIYAP-WDIANAAF 257

  Fly   444 ALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPK--NTSLMRK 506
            .|:...|.||..:.||...|||||:|.:.:...|..||||:|::|.:...:|:.|.  ....:|:
Yeast   258 TLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIPPNALANETVRE 322

  Fly   507 QSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDI---WT-------Q 561
            |:..|.| ||:.|||.||.::.:.|..||.||   ||..:|..|.|....|:   ||       |
Yeast   323 QAQQLIV-HELVHQWMGNYISFDSWESLWFNE---SFATWLACHILEQNGDLSHYWTSEPYLLQQ 383

  Fly   562 FVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNL 626
            ....|...|.:::........:...|..|:..:|||..:|.||..::|.|....||...:||:
Yeast   384 VEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGL-- 446

  Fly   627 YLTRHQYGNTCT--------EDLWAALQE-ASSKNVSDVMTSWTQHKGFPVVSVE-SEQTSKNQR 681
               ...:.:|.|        .|:|..:.: ..|:|:::.::|||:..|.|||.|| .|:..|.|
Yeast   447 ---ESVFEDTKTFHARSVKPMDIWNHIGKFLKSQNITNFVSSWTRTPGLPVVKVEVEEKDGKTQ- 507

  Fly   682 LLRLKQCKFTADGSQADENCLWVVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDW--IKI 744
             .:|.|.:|....|..:::.|..||..|..    .|:.....:|..::.:| |...:.|:  :.|
Yeast   508 -TKLTQHRFINQLSTEEKDQLEDVPYQVPL----FGVLPDGKMDTKNVLLT-DRTLKFDYPILVI 566

  Fly   745 NPGTVGYYRTRY-SQEMLEQLMPAVEKMELPPLDRLGLIDDMFAMV-QAGHASTA------DVLA 801
            |....||||..| |:|....:...:.:..|..:|...:..|:...: ..|..::.      .:|.
Yeast   567 NHLAQGYYRVSYESEECYALINDKITEETLSEIDLRKIFLDLSQFIGDEGFQNSIHLHGLFKILN 631

  Fly   802 LVDSYRNETNYTVWTAITNSLTNLHILISHTDL----MEDFHRFGRNLYEPVAYRLGWEPRDGEN 862
            .:.|...:.....|..::..|..|. .|....|    ::.|.:  :.:..|:..::.|.  .||.
Yeast   632 HIASPSTKIASKYWDPLSKGLEVLQ-TIDRASLTSSKLQSFLK--KKIVIPLFNKIDWP--HGEF 691

  Fly   863 HLDTLLRSLVLTRLVSF---RSSDTIEEAKIRFRRHVNG-TELLPADLRTTCYKAVLQDGD---- 919
            ...|....|.:...|.|   .|:...|..:|.|:..:.| ...:|.:|..:....|.|...
Yeast   692 DKSTNPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQGPRSSVPLELVNSILVVVSQHCANIKQ 756

  Fly   920 -EKIF------------NEMLDLYRATDLHEE---QDRISRALGCCGDLKLLRRVIDFAMSSEVR 968
             :|||            |.::::|........   |:....:||.|.|..::::.::|..|:
Yeast   757 WKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCLDSDIVKKTLNFITSN--- 818

  Fly   969 AQDSVFVIVAVAINPKGRDMA-----WEFFKENNKQ-----------LLERYQGGF--------- 1008
                        |..:|.::|     :.|.|..||.           :.|.|.|.|
Yeast   819 ------------IESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKATR 871

  Fly  1009 -----------LLSRLIKYLIENFASEERAKEVEEFLQVNQIPGCERTVSQAVETIRLNAAW--L 1060
                       .|..:...:.:.|.::|..| :|:|:.:.     :..:.|::  :.|:..|  :
Yeast   872 KGTTTGDHLHKALRSISLIIFQMFVADEPQK-IEKFINLE-----KEKLGQSL--LSLDDIWASV 928

  Fly  1061 QRDREQLAIFLRD 1073
            |:|.|......||
Yeast   929 QQDEESRKTIRRD 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	M1_APN-Q_like	227..662	CDD:341064	125/490 (26%)
		ERAP1_C	741..1055	CDD:463368	68/387 (18%)
TMA108	NP_012129.1	M1_APN-Q_like	15..488	CDD:341064	125/491 (25%)
		ERAP1_C	564..924	CDD:463368	69/387 (18%)