DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and TMA108

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	988	Identity:	227/988 - (22%)
Similarity:	404/988 - (40%)	Gaps:	187/988 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 LPTNVVPRHYELLLQ-------PNLK-----EFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVE 271
            |...|||.||||.|:       ||.|     ...|...:....::::..||..|::.|:::.|..
Yeast     8 LENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAH 72

  Fly   272 LHFECSK--LKPEKIV---YSAENETATLEFAQEIPAETQGVLHMSFTGEL------NDKMKGFY 325
            .....:|  ||..:..   .|..|..:.::.:.:.|.    :|.:.:.|::      :||..|.:
Yeast    73 ATIGSTKFDLKISQDTGKHLSIFNSESPIQLSNDCPL----ILSVQYVGKIRDIKTHHDKTFGIF 133

  Fly   326 RSKYFGPNGEERFAG-------VTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPV 383
            ::.:.     :|..|       .|..:...|...|||.|||:.|:||.:.:.......|:||.||
Yeast   134 KTNFM-----DRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPV 193

  Fly   384 IKEDSLPDGLRR-VRFDRTPIMSTYLVAVVVGEYDY----VEGKSDDGVLVRVFTPVGKREQGTF 443
            ...::|....:. |:|.:||:|:|.:....:|:.::    ::.:.|..:.|.::.| .......|
Yeast   194 EMVEALDSSQKHLVKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIYAP-WDIANAAF 257

  Fly   444 ALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPK--NTSLMRK 506
            .|:...|.||..:.||...|||||:|.:.:...|..||||:|::|.:...:|:.|.  ....:|:
Yeast   258 TLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIPPNALANETVRE 322

  Fly   507 QSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDI---WT-------Q 561
            |:..|.| ||:.|||.||.::.:.|..||.||   ||..:|..|.|....|:   ||       |
Yeast   323 QAQQLIV-HELVHQWMGNYISFDSWESLWFNE---SFATWLACHILEQNGDLSHYWTSEPYLLQQ 383

  Fly   562 FVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNL 626
            ....|...|.:::........:...|..|:..:|||..:|.||..::|.|....||...:||:
Yeast   384 VEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGL-- 446

  Fly   627 YLTRHQYGNTCT--------EDLWAALQE-ASSKNVSDVMTSWTQHKGFPVVSVE-SEQTSKNQR 681
               ...:.:|.|        .|:|..:.: ..|:|:::.::|||:..|.|||.|| .|:..|.|
Yeast   447 ---ESVFEDTKTFHARSVKPMDIWNHIGKFLKSQNITNFVSSWTRTPGLPVVKVEVEEKDGKTQ- 507

  Fly   682 LLRLKQCKFTADGSQADENCLWVVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDW--IKI 744
             .:|.|.:|....|..:::.|..||..|..    .|:.....:|..::.:| |...:.|:  :.|
Yeast   508 -TKLTQHRFINQLSTEEKDQLEDVPYQVPL----FGVLPDGKMDTKNVLLT-DRTLKFDYPILVI 566

  Fly   745 NPGTVGYYRTRY-SQEMLEQLMPAVEKMELPPLDRLGLIDDMFAMV-QAGHASTA------DVLA 801
            |....||||..| |:|....:...:.:..|..:|...:..|:...: ..|..::.      .:|.
Yeast   567 NHLAQGYYRVSYESEECYALINDKITEETLSEIDLRKIFLDLSQFIGDEGFQNSIHLHGLFKILN 631

  Fly   802 LVDSYRNETNYTVWTAITNSLTNLHILISHTDL----MEDFHRFGRNLYEPVAYRLGWEPRDGEN 862
            .:.|...:.....|..::..|..|. .|....|    ::.|.:  :.:..|:..::.|.  .||.
Yeast   632 HIASPSTKIASKYWDPLSKGLEVLQ-TIDRASLTSSKLQSFLK--KKIVIPLFNKIDWP--HGEF 691

  Fly   863 HLDTLLRSLVLTRLVSF---RSSDTIEEAKIRFRRHVNG-TELLPADLRTTCYKAVLQDGD---- 919
            ...|....|.:...|.|   .|:...|..:|.|:..:.| ...:|.:|..:....|.|...
Yeast   692 DKSTNPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQGPRSSVPLELVNSILVVVSQHCANIKQ 756

  Fly   920 -EKIF------------NEMLDLYRATDLHEE---QDRISRALGCCGDLKLLRRVIDFAMSSEVR 968
             :|||            |.::::|........   |:....:||.|.|..::::.::|..|:
Yeast   757 WKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCLDSDIVKKTLNFITSN--- 818

  Fly   969 AQDSVFVIVAVAINPKGRDMA-----WEFFKENNKQ-----------LLERYQGGF--------- 1008
                        |..:|.::|     :.|.|..||.           :.|.|.|.|
Yeast   819 ------------IESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKATR 871

  Fly  1009 -----------LLSRLIKYLIENFASEERAKEVEEFLQVNQIPGCERTVSQAVETIRLNAAW--L 1060
                       .|..:...:.:.|.::|..| :|:|:.:.     :..:.|::  :.|:..|  :
Yeast   872 KGTTTGDHLHKALRSISLIIFQMFVADEPQK-IEKFINLE-----KEKLGQSL--LSLDDIWASV 928

  Fly  1061 QRDREQLAIFLRD 1073
            |:|.|......||
Yeast   929 QQDEESRKTIRRD 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	113/431 (26%)
		M1_APN_2	227..667	CDD:189008	127/495 (26%)
		ERAP1_C	742..1052	CDD:288671	68/381 (18%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	225/986 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.760