DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and APE2

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_012765.3	Gene:	APE2 / 853699	SGDID:	S000001640	Length:	952	Species:	Saccharomyces cerevisiae

Alignment Length:	1036	Identity:	335/1036 - (32%)
Similarity:	537/1036 - (51%)	Gaps:	118/1036 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LLLKTTGDNNS--------------SPRIVANYYRTAPVNPPKQQNPKPSGAADKTTSVKHLFRA 114
            ||||:....:|              .||.::|.|     :||              ..|....|.
Yeast     7 LLLKSAVRGSSLIGKAHPCLRSIAAHPRYLSNVY-----SPP--------------AGVSRSLRI 52

  Fly   115 ESGHLNALISSKQFVKVQKQFYRDFSSVSLGAPLKSSDAPLLGDLCSQYRAILAHTSADVIPGQD 179
            ......:.::..:|||:..:                             |.:...||
Yeast    53 NVMWKQSKLTPPRFVKIMNR-----------------------------RPLFTETS-------- 80

  Fly   180 RHHPGCNYQQIRRAHTQLLSKEQQLEQERKMAQKAKFERLPTNVVPRHYELLLQPNLKEFTFTGK 244
              |.....|:.    :|||:|....            |.||.||||.||:|.::|:.|.|.|.|.
Yeast    81 --HACAKCQKT----SQLLNKTPNR------------EILPDNVVPLHYDLTVEPDFKTFKFEGS 127

  Fly   245 TVVQVNVKEPTTQ-ITLNALDIVLDSVELHFECSKLKPEKIVYSAENETATLEFAQEIPAETQG- 307
            ..:::.:..|... :|||.:|..:.|.::    ..:...:|:...|.:..|..|.:...:..:|
Yeast   128 VKIELKINNPAIDTVTLNTVDTDIHSAKI----GDVTSSEIISEEEQQVTTFAFPKGTMSSFKGN 188

  Fly   308 -VLHMSFTGELNDKMKGFYRSKYFGP-NGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLV 370
             .|.:.|||.|||.|.||||:||... .||.::...||.|.|||||.|||:|||.:||:|.||||
Yeast   189 AFLDIKFTGILNDNMAGFYRAKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLV 253

  Fly   371 VPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPV 435
            .......||||.| |.:.:.||.:...|:.||.|||||||.:|.|..|||.| :..:.|||:...
Yeast   254 SDPSLTHLSNMDV-KNEYVKDGKKVTLFNTTPKMSTYLVAFIVAELKYVESK-NFRIPVRVYATP 316

  Fly   436 GKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKN 500
            |..:.|.||.::..|.|.:::..|.|.|||||||.:|:.:|||||||||||||||...:|:|..|
Yeast   317 GNEKHGQFAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDN 381

  Fly   501 TSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTD 565
            ::|.|.|.:|..|.||:|||||||||||:||..||||||:|:::.:...:...||:.:|.|:|||
Yeast   382 STLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTD 446

  Fly   566 MYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTR 630
            ....||.||||::||||||||....||::|||.|||:||||::||:..::||:||.||::.||.:
Yeast   447 TLQHALSLDSLRSSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNK 511

  Fly   631 HQYGNTCTEDLWAALQEASSKNVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKF--TAD 693
            .:|||..|||||.||.:||.|:|..||..||:..||||:||..:...|    :..:|.::  |||
Yeast   512 FKYGNAKTEDLWDALADASGKDVRSVMNIWTKKVGFPVISVSEDGNGK----ITFRQNRYLSTAD 572

  Fly   694 GSQADENCLWVVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQ 758
            ....::..::.|.:::.| ||  |:..:.:|.:.|..:.|   ::..:.|:|....|.|.|.|:.
Yeast   573 VKPDEDKTIYPVFLALKT-KN--GVDSSVVLSERSKTIEL---EDPTFFKVNSEQSGIYITSYTD 631

  Fly   759 EMLEQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLT 823
            |...:|....:.:.:.  ||:||:.|:..:..:|:.||.:.|.||..:.||.::.||..|.||::
Yeast   632 ERWAKLGQQADLLSVE--DRVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSIS 694

  Fly   824 NLHI--LISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIE 886
            ::..  |....:..:....|.:.|...:.:.||||.:..::.....|:..:.....:.|.:| :|
Yeast   695 SMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQRLKVTMFGAACAARDAD-VE 758

  Fly   887 EAKIR-FRRHVNGT-ELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCC 949
            :|.:: |..:.:|. |.:||.::...:..|.:.|..:.:.::..:|.....::|:....|:||..
Yeast   759 KAALKMFTDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRF 823

  Fly   950 GDLKLLRRVIDFAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQGGF-LLSRL 1013
            .:.|||.|.:.:.....|..||....:..:..:.:|.:..|.:.|:|..:|::|...|. :|..:
Yeast   824 KEPKLLERTLGYLFDGTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSV 888

  Fly  1014 IKYLIENFASEERAKEVEEFLQVNQIPGCERTVSQAVETIRLNAAWLQRDREQLAIFLRDD 1074
            :......|.|.::..|:::|.......|.:::::|:::||...|.|:.|||:.:..:|:::
Yeast   889 VTLGTSGFTSMQKIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWVNRDRDVVNKYLKEN 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	179/389 (46%)
		M1_APN_2	227..667	CDD:189008	206/443 (47%)
		ERAP1_C	742..1052	CDD:288671	71/314 (23%)
APE2	NP_012765.3	PepN	90..941	CDD:223385	313/881 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345495
Domainoid	1	1.000	264	1.000	Domainoid score	I296
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36199
Inparanoid	1	1.050	549	1.000	Inparanoid score	I167
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	1	1.010	-	-		QHG53945
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm46696
orthoMCL	1	0.900	-	-		OOG6_100948
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2032
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	14	13.680