Protein Alignment Psa and AOPEP

DIOPT Version :10

• Sequence 1: NP_728614.1
• Gene: Psa / 38175
• FlyBaseID: FBgn0261243
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_001372995.1
• Gene: AOPEP / 84909
• HGNCID: 1361
• Length: 859
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 134/680 - (19%)
• Similarity: 236/680 - (34%)
• Gaps: 221/680 - (32%)

  Fly   234 PNLKEFTFTGK-TVVQVNVKEPTTQ--ITLNALDIVLDSVELHFECSKLKP-EKIVYSAENETAT 294
            |.|::||.:.: |||....:....:  :||.| :...:.::.:..||:... .::::  :.:|.:
Human   165 PGLEKFTRSPELTVVSEEFRNQIVRELVTLPA-NRWREQLDYYARCSQAPGCGELLF--DTDTWS 226

  Fly   295 LEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRC------- 352
            |:. ::..|:|        ..:....::.:|::|   |.|.    .||.......|.|
Human   227 LQI-RKTGAQT--------ATDFPHAIRIWYKTK---PEGR----SVTWTSDQSGRPCVYTVGSP 275

  Fly   353 ------FPCWDEPAIKATFDITLVVPKDRVAL-SNMPVIKEDSLPDGLRRVRFDRTPIM--STYL 408
                  |||.:.|...:|:..|:......|.| |.....|...|.:......:..|..|  ||:.
Human   276 INNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFT 340

  Fly   409 VAV---------------------------------VVGEYDY------VEGKSDDGVLVRVFTP 434
            :||                                 |....:|      ....:.:.:..|||.|
Human   341 IAVGCWTEMKMETWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAP 405

  Fly   435 V---GKREQGTF-----ALEVATKVLPYYKDYFNIAYPLPKMD-LIAISDFSAGAMENWGLVTYR 490
            |   |..::...     .|..|..||.        |:|..::| ||..::|     .:.|:.:..
Human   406 VCLTGACQETLLRLIPPCLSAAHSVLG--------AHPFSRLDVLIVPANF-----PSLGMASPH 457

  Fly   491 ETFVLVDPKNTSLMRKQSIALTVG---------HEIAHQWFGNLVTMEWWTHLWLNEGYASFVE- 545
            ..|:           .||| ||.|         |||||.|||..:....||..||:||:|:.:|
Human   458 IMFL-----------SQSI-LTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLED 510

  Fly   546 -FLCVHHLFPEYDI-----------WTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEI------ 592
             |.........|:.           |.:...:|.....|:..|:   |.:...||.|:.
Human   511 VFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLR---PSKDKTGHTSDSGASVIK 572

  Fly   593 -----DEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSK- 651
                 ::||.::.|.||..::|.|...:|::|:...:..::.........::|....|.|...:
Human   573 HGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEE 637

  Fly   652 -----NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVST 711
                 :|.::...|.:..|.|       :..:.:|              :|...|
Human   638 KRLELSVENIYQDWLESSGIP-------KPLQRER--------------RAGAEC---------- 671

  Fly   712 SKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKIN--PGTVGYYRTRYSQEMLEQLMP-------- 766
                 |:|:     :...|||       .||.:|  |..   .:.|..:|:.|:|:|
Human   672 -----GLAR-----QVRAEVT-------KWIGVNRRPRK---RKRREKEEVFEKLLPDQLVLLLE 716

  Fly   767 -AVEKMELPP-----LDRLGLIDDMFAMVQ 790
             .:|:..|.|     |.|...:.|..|.|:
Human   717 HLLEQKTLSPRTLQSLQRTYHLQDQDAEVR 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	M1_APN-Q_like	227..662	CDD:341064	107/534 (20%)
		ERAP1_C	741..1055	CDD:463368	17/66 (26%)
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:472708	90/442 (20%)
		Nucleolar localization signal. /evidence=ECO:0000250|UniProtKB:Q8BXQ6	689..699		2/12 (17%)
		Leuk-A4-hydro_C	721..>771	CDD:462686	7/26 (27%)