DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and APM1

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_195035.2	Gene:	APM1 / 829446	AraportID:	AT4G33090	Length:	879	Species:	Arabidopsis thaliana

Alignment Length:	884	Identity:	395/884 - (44%)
Similarity:	541/884 - (61%)	Gaps:	61/884 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHF---ECSK- 278
            |||...||:.|:|.|.|:|...||||...:.:::...|..|.|||.|:.::...:.|   ..||
plant     9 RLPKFAVPKRYDLRLNPDLIACTFTGTVAIDLDIVADTRFIVLNAADLSVNDASVSFTPPSSSKA 73

  Fly   279 LKPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQ 343
            |...|:|...|:|...|||.:.:| ...|||.:.|.|.|||||||||||.| ..|||::...|||
plant    74 LAAPKVVLFEEDEILVLEFGEILP-HGVGVLKLGFNGVLNDKMKGFYRSTY-EHNGEKKNMAVTQ 136

  Fly   344 FEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYL 408
            ||..|||||||||||||.||||.|||.||.|.|||||||:: |:.:...|:.|.:..:|||||||
plant   137 FEPADARRCFPCWDEPACKATFKITLEVPTDLVALSNMPIM-EEKVNGNLKIVSYQESPIMSTYL 200

  Fly   409 VAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAI 473
            ||:|||.:||||..:.||:.|||:..|||.:||.|||.|..|.|..:|:||.:.|||||||:|||
plant   201 VAIVVGLFDYVEDHTSDGIKVRVYCQVGKADQGKFALHVGAKTLDLFKEYFAVPYPLPKMDMIAI 265

  Fly   474 SDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNE 538
            .||:||||||:||||||||.:|.|.::::...||.:|..|.||:|||||||||||||||||||||
plant   266 PDFAAGAMENYGLVTYRETALLYDEQHSAASNKQRVATVVAHELAHQWFGNLVTMEWWTHLWLNE 330

  Fly   539 GYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNK 603
            |:|::|.:|....||||:.|||||: |..|..|.||.|:.||||||.|.|.:|||||||.|||.|
plant   331 GFATWVSYLATDSLFPEWKIWTQFL-DESTEGLRLDGLEESHPIEVEVNHAAEIDEIFDAISYRK 394

  Fly   604 GASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSKNVSDVMTSWTQHKGFPV 668
            ||||||||..|:|.:.|:|.:..|:..|.|.|..||||||||:..|.:.|:.:|:|||:.||:||
plant   395 GASVIRMLQSYLGAEVFQKSLAAYIKNHAYSNAKTEDLWAALEAGSGEPVNKLMSSWTKQKGYPV 459

  Fly   669 VSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISV---STSKNPTGIAKTFLLDKSSME 730
            ||.:.:...     |.|:|.:|.:.||..:..  |:||:::   |..|.     |.|||:..|..
plant   460 VSAKIKDGK-----LELEQSRFLSSGSPGEGQ--WIVPVTLCCGSYEKR-----KNFLLESKSGA 512

  Fly   731 VTLDNV------DEDD-------WIKINPGTVGYYRTRYSQEMLEQLMPAVEKMELPPLDRLGLI 782
            ..|..:      |..|       |||||....|:||.:|...:...|..|.|...|..:||.|::
plant   513 YDLKELLGCSIADGSDKINGTCSWIKINVDQAGFYRVKYDDSLAAGLRNATESQSLTSIDRYGIL 577

  Fly   783 DDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISH----------TDLMED 837
            ||.||:..|...|.|.:|.|..:|:.|.:|||       |:|| |.||:          .:||..
plant   578 DDSFALTMARQQSLASLLTLCSAYKKELDYTV-------LSNL-IAISYKVVKIGADANQELMSG 634

  Fly   838 FHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHV--NGTE 900
            ...|...:::..|.:|||:|:.||:|||.:||..|||.|..|...:|::||..||...:  ..|.
plant   635 IKHFFIGVFQFAAGKLGWDPKQGESHLDAMLRGEVLTALAVFGHDETLKEAVRRFDAFLADRNTP 699

  Fly   901 LLPADLRTTCYKAVLQ---DGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFA 962
            |||.|:|...|.||:|   ..|:..:..:|.:||.|||.:|:.||..:|..|.|..:::.|::|.
plant   700 LLPPDIRRAAYVAVMQRANKSDKSGYESLLRVYRETDLSQEKTRILGSLASCPDPTIVQDVLNFV 764

  Fly   963 MSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQGGFLLSRLIKYLIENFASEERA 1027
            :|.|||.||:::.:..|:.  :||::||::.:|..:.:...:..|||::|.|..::..|||.|:|
plant   765 LSDEVRNQDALYGLSGVSW--EGREVAWKWLQEKWEYIGNTWGSGFLITRFISAVVSPFASFEKA 827

  Fly  1028 KEVEEFLQVNQIPGCERTVSQAVETIRLNAAWLQRDREQ 1066
            ||||||......|...||:.|::|.:.:||.|::..:::
plant   828 KEVEEFFATRSKPSMARTLKQSIERVHINANWVESIKKE 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	217/389 (56%)
		M1_APN_2	227..667	CDD:189008	245/443 (55%)
		ERAP1_C	742..1052	CDD:288671	117/324 (36%)
APM1	NP_195035.2	M1_APN-Q_like	18..453	CDD:341064	242/438 (55%)
APM1	NP_195035.2	ERAP1_C	536..855	CDD:403137	119/328 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	281	1.000	Domainoid score	I396
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36199
Inparanoid	1	1.050	709	1.000	Inparanoid score	I127
OMA	1	1.010	-	-		QHG53945
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		oto3471
orthoMCL	1	0.900	-	-		OOG6_100948
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840