Protein Alignment Psa and Erap1

DIOPT Version :10

• Sequence 1: NP_728614.1
• Gene: Psa / 38175
• FlyBaseID: FBgn0261243
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_109636.1
• Gene: Erap1 / 80898
• MGIID: 1933403
• Length: 930
• Species: Mus musculus
• Alignment Length: 901
• Identity: 287/901 - (31%)
• Similarity: 476/901 - (52%)
• Gaps: 59/901 - (6%)

  Fly   218 RLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKL--- 279
            |||..:.|.||:|::..||...||.|||.|::....||:.|.:::..:.:....|.....::
Mouse    42 RLPEYMTPIHYDLMIHANLSTLTFWGKTEVEIIASRPTSTIIMHSHHLQISKATLRRGAGEMLSE 106

  Fly   280 KPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQF 344
            :|.|::....:|...|..||.:.|.:...:.:.:...|::...|||:|.|....||.|....|||
Mouse   107 EPLKVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTYRTQEGEMRILAATQF 171

  Fly   345 EATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLV 409
            |.|.||..|||:||||:||:|.|.:......:|:||||::|..::.:||....||.|..||||||
Mouse   172 EPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVNVAEGLIEDHFDITVKMSTYLV 236

  Fly   410 AVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAIS 474
            |.::.::..|...:..||.|.|:....|..|..:||:.|..:|.:|:|||||.|||||.||.||.
Mouse   237 AFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFNIPYPLPKQDLAAIP 301

  Fly   475 DFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEG 539
            ||.:||||||||.||||:.:|.|.:.:|...|..|.:.|.||:||||||||||||||..||||||
Mouse   302 DFQSGAMENWGLTTYRESSLLYDKEKSSASSKLGITMIVSHELAHQWFGNLVTMEWWNDLWLNEG 366

  Fly   540 YASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKG 604
            :|.|:||:.|....||..:...|....: .|:|:|:|.:|||:..||.:|::|.|:||::||.||
Mouse   367 FAKFMEFVSVTVTHPELKVEDYFFGKCF-NAMEVDALNSSHPVSTPVENPAQIREMFDDVSYEKG 430

  Fly   605 ASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAAL-------------------QEASS 650
            |.::.||.||:..|||::|:..||.::.|.||..||||.::                   |.:||
Mouse   431 ACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRSQHSSS 495

  Fly   651 K--------NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADE-NCLWVVP 706
            .        :|..:|.:||..||||::::     :.:.|.:.:||..:.....:..| ..||.||
Mouse   496 TSHWRQEVVDVKTMMNTWTLQKGFPLITI-----TVSGRNVHMKQEHYMKGSERFPETGYLWHVP 555

  Fly   707 ISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEKM 771
            ::..|||:.: :.:..|..|:.:.:..:.|   .|||.|.|..|||...|:.:....|...:::.
Mouse   556 LTFITSKSDS-VQRFLLKTKTDVLILPEAV---QWIKFNVGMNGYYIVHYADDGWASLSGLLKEA 616

  Fly   772 E--LPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDL 834
            .  :...||..||::.|.:|.....|....|.|....:|||.........|.|..::.|:...|:
Mouse   617 HTTISSNDRASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIMPIFQALNELIPMYKLMEKRDM 681

  Fly   835 ME---DFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFR--R 894
            :|   .|..|...|.:.:..:..|  .|..:..:.:|||.:|...........::.|:..||  :
Mouse   682 IEVETQFKDFLLKLLKDLIDKQTW--TDEGSVSERMLRSQLLLLACVRNYQPCVQRAERYFREWK 744

  Fly   895 HVNGTELLPADLRTTCYKAVLQ--DGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRR 957
            ..||...:|.|:....:....|  :|.:.::::    |:::....|:.:|..:|....|.:.|:.
Mouse   745 SSNGNMSIPIDVTLAVFAVGAQNTEGWDFLYSK----YQSSLSSTEKSQIEFSLCTSKDPEKLQW 805

  Fly   958 VIDFAMSSE-VRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIEN 1020
            ::|.:...| ::.|:...::..:..||.|..:||:|.:||..:|::::: |...::.::....:.
Mouse   806 LLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLRENWNKLVQKFELGSSSIAHMVMGTTDQ 870

  Fly  1021 FASEERAKEVEEFLQVNQIPGCE-RTVSQAVETIRLNAAWLQRDREQLAIFLRDDQ 1075
            |::..|.:||:.|....:..|.: |.|.|.:|||..|..|:.::.:::.::|:.::
Mouse   871 FSTRARLEEVKGFFSSLKENGSQLRCVQQTIETIEENIRWMDKNFDKIRLWLQKEK 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	M1_APN-Q_like	227..662	CDD:341064	185/464 (40%)
		ERAP1_C	741..1055	CDD:463368	76/325 (23%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	185/465 (40%)
		ERAP1_C	586..905	CDD:463368	75/324 (23%)