DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and Lvrn

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_083284.1	Gene:	Lvrn / 74574	MGIID:	1921824	Length:	991	Species:	Mus musculus

Alignment Length:	926	Identity:	262/926 - (28%)
Similarity:	439/926 - (47%)	Gaps:	109/926 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLK-------EFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVEL--- 272
            |||..:||.||:|.|.|.|:       ..||||:..:.|.....::::.|::..:....||:
Mouse    94 RLPPWLVPLHYDLELWPWLQPDKLSPPNLTFTGRVNITVRCTVASSRLLLHSFLLNYKQVEVWGP 158

  Fly   273 ------HFECSKLKPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGE-LNDKMKGFYRSKYF 330
                  :....:::.||:.::.:.:...|:..|.:...::..|...|:|: |...::|.:.:.|.
Mouse   159 LAQDTRNATVGRVQVEKVWFAPDMQFVVLDLGQSLEPGSRYELSFHFSGQVLQVGLEGLFLNLYH 223

  Fly   331 GPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPD--GL 393
            ..: |.|....||.|.|.||..|||:||||:||||:||::......||||||.:.:....|  |.
Mouse   224 DED-ELRALVATQMEPTFARHVFPCFDEPALKATFNITVIHHPGYAALSNMPQLGQSERIDVNGS 287

  Fly   394 R--RVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQG--TFALEVATKVLPY 454
            |  ...|..||.|.|||||:||.:.|:: .:::.|..:||:........|  .||..:...:..:
Mouse   288 RWTVTTFHTTPRMPTYLVALVVCDLDHI-SRTERGKEIRVWARKDDIASGYLDFAANITGPIFSF 351

  Fly   455 YKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAH 519
            .:|.|||:|.|||.|::|:..|::||||||||:.:.|:.:|::|::....::..|...:.||:.|
Mouse   352 LEDLFNISYRLPKTDIVALPIFASGAMENWGLLIFDESSLLLEPEDELTEKRAMILSIIAHEVGH 416

  Fly   520 QWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEV 584
            |||||||||.||.::|||||:||:.|....::.:|:..:...|...:....|..|....|..:..
Mouse   417 QWFGNLVTMSWWNNIWLNEGFASYFELELTNYFYPKVPMNMIFFFTVLHGILGEDHALESRAVST 481

  Fly   585 PVGH---PSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQ 646
            .|.:   .|||:.:||..:|.|||.:..||..::....|...:..||....|.|...:|||..:|
Mouse   482 AVENFTETSEINRLFDLYTYKKGACMAWMLASFLSPHLFINALKSYLETFSYSNAEQDDLWRHIQ 546

  Fly   647 EASSK--------NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQ----ADE 699
            .|..:        .|..:|.|||...|||:::|       |.....:||..|..|..:    ...
Mouse   547 MAIGEQNVTHLPATVKGIMDSWTHRGGFPIITV-------NVSTGVVKQEPFYLDKVENQTLLSH 604

  Fly   700 NCLWVVPISVSTSKNPTGIAKTFL-LDKSSM---EVTLDNVDEDDWIKINPGTVGYYRTRYSQEM 760
            |..|:|||  ...||  ||.:..: ||||:|   .:.|.:.| .||:.:|....||||..|.:..
Mouse   605 NSTWIVPI--FWMKN--GIPQPLVWLDKSNMMFPGMKLSDSD-SDWVILNFNVTGYYRVNYDELG 664

  Fly   761 LEQLMPAVEK--MELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLT 823
            .::|...:||  ..:|.::||.|:.|.||:.:..:......|.|......|....||..:..:|.
Mouse   665 WKKLSEQLEKDPKAIPVINRLQLVSDAFALTKNNYIEIETALDLTKYIAEEDEILVWFEVLLNLI 729

  Fly   824 NLHILISHTD-----LMEDF--HRFGR--NLYEPVAYRLGWEPRDGENHL-DTLLRSLVLTRLVS 878
            |..::....:     |::.:  .||..  |.|..:.       |:....| |..|....|.|:
Mouse   730 NREVIYDVNNYALYPLLKKYLLKRFNSIWNTYSAII-------RENVASLQDNYLSLFSLERI-- 785

  Fly   879 FRSS------DTIEEAKIRFRRHVNGTE-LLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLH 936
            |.::      |.::.::..|::.....| .:|..:......:.:..|.:|.::.:.:||..|...
Mouse   786 FETACWLGLEDCLQLSRELFKKWTAHPETAIPPQIENAVLCSAVALGSDKDWDFLFNLYINTTEE 850

  Fly   937 EEQDRISR---ALGCCGDLKLLRRVIDFAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNK 998
            |::.|..|   |:.|..|..:|.|.:::|:::.........:||.||.:..||.:|.:|..:|..
Mouse   851 EDESRRRRLVHAMSCSKDPWILNRFMEYAITAVSSNFSETNIIVVVATSEVGRYIAKDFLMDNWV 915

  Fly   999 QLLERYQGGFLLSRLIKYLIENFASEERAKEVEEF----LQVNQIPGCERTV----SQAVETIRL 1055
            .:.||| |...|..|:..|....:::::..|::.|    |:.:|     |.|    .||::|..|
Mouse   916 AVTERY-GMDWLDALVPVLGRTVSTDQQVTELQHFFSTVLEEHQ-----RVVVQAKLQAMKTKNL 974

  Fly  1056 N--------AAWLQRD 1063
            .        ..||:::
Mouse   975 QNKKRIARVVEWLRKN 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	134/411 (33%)
		M1_APN_2	227..667	CDD:189008	150/473 (32%)
		ERAP1_C	742..1052	CDD:288671	77/339 (23%)
Lvrn	NP_083284.1	Peptidase_M1	94..504	CDD:279741	134/411 (33%)
		M1_APN_2	102..575	CDD:189008	150/474 (32%)
		Substrate binding. /evidence=ECO:0000250	376..380		3/3 (100%)
		ERAP1_C	646..964	CDD:288671	75/332 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820