DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and Enpep

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	873	Identity:	288/873 - (32%)
Similarity:	471/873 - (53%)	Gaps:	40/873 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSV-ELHFECSKLKP 281
            |||..:.|.||:|.::..::|..:||...:.||:.:.|..:.|:..:..:..: ||.....:..|
  Rat    84 RLPDFIQPVHYDLEVKVLMEEDRYTGIVSISVNLSKDTRDLWLHIRETRITKLPELRRPSGEQVP 148

  Fly   282 EKIVYSAENETATLEFAQEIPAETQG----VLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVT 342
            .:..:..:.:...:..|:|..|.|.|    .|.:.|.|.||..:.||||:.| ..:|:.:....|
  Rat   149 IRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGFYRTTY-TEDGQTKSIAAT 212

  Fly   343 QFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTY 407
            ..|.||||:.|||:|||..|||::|:|:.||:..|||||||.||::|.:..::..|.::..||||
  Rat   213 DHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVEKEETLDNDWKKTTFMKSVPMSTY 277

  Fly   408 LVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIA 472
            ||...|.::..::..|..|..:.|:....:::...:|..:...|..:::|||.:.|.|||:|.||
  Rat   278 LVCFAVHQFTSIQRTSRSGKPLTVYVQPNQKQTAEYAANITKAVFDFFEDYFAMEYSLPKLDKIA 342

  Fly   473 ISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLN 537
            |.||..||||||||||||||.:|.||..::...:|.:|..|.||:.||||||:|||:||..||||
  Rat   343 IPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHELVHQWFGNIVTMDWWDDLWLN 407

  Fly   538 EGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYN 602
            ||:|||.|||.|:|...::.:.:|.:.:......|.|||.:|||:.|.|..|:||..:||.|||:
  Rat   408 EGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMSSHPVVVTVSTPAEITSVFDGISYS 472

  Fly   603 KGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSKNVSDVMTSWTQHKGFP 667
            ||||::|||.|:|..:.|:||..:||...::.|..|.|.|.:|::||::.|.:||.:||...|:|
  Rat   473 KGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSDFWDSLEKASNQPVKEVMDTWTSQMGYP 537

  Fly   668 VVSVESEQTSKNQRLLRLKQCKFTADGSQADE--NCLWVVPISVSTSKNPTGIAKTFLLDKSSME 730
            ||:|..:|....:|.|    ..:.||.||...  ...|.:||..:.:.|    :...:..:|:.|
  Rat   538 VVTVSGKQNVTQKRFL----LDYKADPSQPPSALGYTWNIPIKWTENGN----SNITVYYRSNRE 594

  Fly   731 -VTLD-NVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEK--MELPPLDRLGLIDDMFAMVQA 791
             :||: |:..|.::||||..:|:||..|..|..:.:...:..  |.....||...|||.||:.:|
  Rat   595 GITLNANLSGDGFLKINPDHIGFYRVNYEAETWDWIAETLSSNHMNFSSADRSSFIDDAFALARA 659

  Fly   792 GHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMED-------FHRFGRNLYEPV 849
            ........|.|.....:|.::..|..:.::::   .:||   :.||       ...:.|:..:|:
  Rat   660 QLLDYEKALNLTRYLTSEKDFLPWERVISAVS---YIIS---MFEDDRELYPLIETYFRSQVKPI 718

  Fly   850 AYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGTELLPADLRTTCYKAV 914
            |..|||:  |..:|:..|||:.||.......:.:.:..|...|...:.|.|.:|.:||...|:..
  Rat   719 ADSLGWQ--DTGSHITKLLRASVLGFACKMGAGEALGNASQLFEAWLKGNESIPVNLRLLVYRYG 781

  Fly   915 LQD-GDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSE-VRAQDSVFVIV 977
            :|: |:|..:|..|:.|:.|.|.:|::::...|....|:.||.|.::...... ::.||...||.
  Rat   782 MQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVTLLARYLEMLKDPNIIKTQDVFTVIR 846

  Fly   978 AVAINPKGRDMAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIPG 1041
            .::.|..|:.|||.:.:.|...|:.|:. ....|.|::. :.|.|.:|.:..:::.|.......|
  Rat   847 YISYNSYGKSMAWNWIQLNWDYLVNRFTINDRYLGRIVT-IAEPFNTELQLWQMQSFFAKYPNAG 910

  Fly  1042 C-ERTVSQAVETIRLNAAWLQRDREQLA 1068
            . .:...|.:||::.|..||:.:|:.::
  Rat   911 AGAKPREQVLETVKNNIEWLKLNRKSIS 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	153/390 (39%)
		M1_APN_2	227..667	CDD:189008	176/444 (40%)
		ERAP1_C	742..1052	CDD:288671	81/322 (25%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77
		Peptidase_M1	84..474	CDD:279741	153/390 (39%)
		M1_APN_2	92..537	CDD:189008	176/445 (40%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		3/3 (100%)
		ERAP1_C	608..922	CDD:288671	81/322 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920