DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psa and si:ch211-106j24.1

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_021327531.1	Gene:	si:ch211-106j24.1 / 555478	ZFINID:	ZDB-GENE-130530-595	Length:	960	Species:	Danio rerio

Alignment Length:	896	Identity:	277/896 - (30%)
Similarity:	455/896 - (50%)	Gaps:	61/896 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNL-----KEFTFTGKTVVQVNVKEPTTQITL--NALDIVLDSVELHFE 275
            |||..:.|::|.:.|.|.:     ..:.|||.:.|.....:.|..|.:  |.|::.|    .:..
Zfish    67 RLPDTLSPQYYNITLWPQMVMDANGMYIFTGISDVMFTCVKKTDLILIHSNKLNLTL----FNGR 127

  Fly   276 CSKLKPEKIVYSAENETATLEF-AQEIPAETQGV--------LHMSFTGELNDKMKGFYRSKYFG 331
            .:||.....|.:...::..|:. .|.:..:.:|.        ||..|||||.|.::|||||:|.
Zfish   128 HAKLTGMSGVTAPAIKSTWLQTQTQYLVIQLKGKLNPGKSYWLHTEFTGELADDLEGFYRSEYM- 191

  Fly   332 PNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIK-EDSLPDGL-- 393
            .:||::...:||.:||.||:.|||:|||.:||.|:|.|:..:...||||...|: ||.:.|.:
Zfish   192 EDGEKKIIAITQMQATYARKAFPCFDEPGMKAVFNIILIHDRGMTALSNSQEIRTEDVIIDEMPV 256

  Fly   394 RRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKRE----QGTFALEVATKVLPY 454
            .|..|:.|..|||||||.||.::.|:..:...|||||::  ..|:.    ||.:||.:...:|.:
Zfish   257 TRTTFEPTARMSTYLVAFVVSDFSYINNEDKAGVLVRIW--ARKKAIDDGQGDYALSITQPILEF 319

  Fly   455 YKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAH 519
            ::.|:|.:|||.|.|.:|:.||::||||||||||||||.:|.||:.::...||.||..|.||:||
Zfish   320 FESYYNTSYPLSKSDQVALPDFNSGAMENWGLVTYRETALLYDPQTSANGNKQRIATVVSHELAH 384

  Fly   520 QWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPI-- 582
            .|||||||::||..||||||:||:||:|...|..|.::|..|.:.....||..:|||.:|||:
Zfish   385 MWFGNLVTLKWWNDLWLNEGFASYVEYLGADHAEPTWNIKDQIILYDMQRAFAVDSLTSSHPLSR 449

  Fly   583 -EVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQ 646
             |..|..|:||.|:|..|||:|||:|::||.:::.|..|.||::.||.:..:|::...|||..||
Zfish   450 KEEEVNTPAEISEMFSTISYSKGAAVLKMLSEFLTEPVFAKGLSNYLKQFAFGSSVHSDLWDHLQ 514

  Fly   647 EASS--------KNVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLW 703
            ::..        :::.::|:.|....||||:::::...:.:|:...::  |......:::.|..|
Zfish   515 KSLDQAPGMKLPRSIHEIMSRWILQMGFPVITIDTRTGNVSQKHFLVE--KDAVVERKSEFNYEW 577

  Fly   704 VVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAV 768
            .|||  ...|......:.:||.||::...: .|.:.:|:..|....||:|..|.....|:|:..:
Zfish   578 FVPI--KWMKKGQVQDQMWLLQKSAIHKPM-KVSKGEWVLANHKVSGYFRVNYDHGNWERLLSQL 639

  Fly   769 E--KMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISH 831
            |  ...:|.::|..::||.|.:.:|...:....|........|..|..|.|...||.....|...
Zfish   640 ETNHQTIPVVNRAQILDDAFNLARASIINITLALRTTKYLVREREYIPWEAALRSLNYFFQLFDR 704

  Fly   832 TDLMEDFHRFGRNLYEPVAYRLG-----WEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIR 891
            .::......:.:...:|:....|     | .:....|.|...:.:.|:...........|..|..
Zfish   705 NEVYGALQAYLKKQVKPLFEHFGTISSNW-TKVPNGHTDQFTQIIALSLACGTGVEGCREITKSW 768

  Fly   892 FRRHVNGTELLP--ADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKL 954
            |::.:....:.|  .:||:|.|...:..|....:|....:::...:..|..::..||.|.....|
Zfish   769 FKKWMQNPRVNPIHPNLRSTVYCNAIAAGGADEWNFGWQMFQKATVAAEAVKLRAALACTKVPWL 833

  Fly   955 LRRVIDFAMSSE-VRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERY-QGGFLLSRLIKYL 1017
            |.|.::::::.| :|.||:...|..:|.|..|:.:||:|.:.|.....:.| .|.|..||||..:
Zfish   834 LNRYLEYSINPEKIRKQDATSTIGYIASNVIGQPLAWDFVRANWDYFFKVYGTGSFTFSRLISDI 898

  Fly  1018 IENFASEERAKEVEEFLQVNQIPGC---ERTVSQAVETIRLNAAWLQRDRE 1065
            ...|.:.....:::.|.:.|...|.   .:.:.||:|.......||..::|
Zfish   899 TSKFCTPFELSQLKRFQKDNAETGFGSGTQALQQAIERTTAKIKWLAENKE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	165/411 (40%)
		M1_APN_2	227..667	CDD:189008	182/473 (38%)
		ERAP1_C	742..1052	CDD:288671	70/323 (22%)
si:ch211-106j24.1	XP_021327531.1	M1_APN_2	77..543	CDD:189008	182/472 (39%)
si:ch211-106j24.1	XP_021327531.1	PepN	170..943	CDD:223385	252/781 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920