DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psa and SP1029

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster

Alignment Length:	922	Identity:	284/922 - (30%)
Similarity:	461/922 - (50%)	Gaps:	96/922 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 FERLPTNVVPRHYE---LLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLD--SVELHFE 275
            :.||||::.|:.|.   |.|..|.::..|:|...:.:...|.|..:||::.::.:|  .:.|...
  Fly    31 YYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQI 95

  Fly   276 CSKLKPEKIVYSA----ENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGE- 335
            ..:.|.|..|.|.    .::...|...||:.|.....|:|.|..:||.:::|:|||.|..|...
  Fly    96 GGEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANL 160

  Fly   336 ERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKE----DSLPDGLRRV 396
            .::..|||||...||..|||:|||..||.|.:||...|...|:||||. ||    ::|.|.: ..
  Fly   161 TKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMPE-KETKPHETLADYI-WC 223

  Fly   397 RFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNI 461
            .|..:..|||||||..|.::.:......:..|.|.:......:|..:|.:...|||.||:.:|.|
  Fly   224 EFQESVPMSTYLVAYSVNDFSHKPSTLPNSALFRTWARPNAIDQCDYAAQFGPKVLQYYEQFFGI 288

  Fly   462 AYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLV 526
            .:||||:|.||:.|||||||||||||||||..:|....::||..||.:|..|.||:|||||||||
  Fly   289 KFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQWFGNLV 353

  Fly   527 TMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALEL---DSLKNSHPIEVPVGH 588
            ||:|||.||||||:|::|..|.|.::.||   |.....:..:..|.:   |:|::||||..|:..
  Fly   354 TMKWWTDLWLNEGFATYVASLGVENINPE---WRSMEQESLSNLLTIFRRDALESSHPISRPIQM 415

  Fly   589 PSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSK-- 651
            .|||.|.||:|||.||::|:||:|.::||::||.|:..||.:..|.|...::||.:|.:|:.|
  Fly   416 VSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQAAHKYR 480

  Fly   652 ------NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVS 710
                  ::..:|.|||...|:||::|..:..::..:|.:.:....|.........|.| ||:|.:
  Fly   481 SLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQVARAYRGGCWW-VPLSYT 544

  Fly   711 T-----------------SKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQ 758
            |                 .||...:.||.          .|....|.|:..|......|:..|..
  Fly   545 TQAVQDFNNTAPKAWMECGKNGESLPKTI----------QDLPGPDQWVIFNTQLSTLYKVNYDA 599

  Fly   759 EMLEQLMPAV-----EKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAI 818
            :..:.|:..:     |::.:  ::|..||||...:...|.......:.|::..:.|..|..|.:.
  Fly   600 QNWKLLIETLTNGDFERIHV--INRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYLPWKSA 662

  Fly   819 TNSLTNLHILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHLDT----------LLRSLVL 873
            ..:|..:..::..|...|.|.|:.:.|..|:     :|..:|.|  ||          ||:::|:
  Fly   663 FENLKRVGRIVRQTPDFEFFKRYMKKLILPI-----YEHLNGIN--DTFSAIPQQDQVLLKTMVV 720

  Fly   874 TRLVSFRSSDTIEEAKIRFRR---HVNGTEL--LPADLRTTCYKAVLQDGDEKIFNEMLDLYRAT 933
            .....::..|.:.:|...:|.   ..|..|.  :|.::|:|.|...::.|.:..:..:...|:.:
  Fly   721 NWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKHGSDSDWEFLWTRYKKS 785

  Fly   934 DLHEEQDRISRALGCCGDLKLLRRVID--FAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKEN 996
            ::..|:..|..||||..::.||:|.::  |.....:|.|||::...|||.|..|..:|.::|.:|
  Fly   786 NVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDN 850

  Fly   997 NKQLLERYQGGFL---LSRLIKYLIENFASEERAKEVEEFLQVNQ--IPGCERTVSQAVETIRLN 1056
            ...:.:.|..  |   :|||:..|.|...:.....|.::|:..::  :.|.|:.:.|.:|.:..|
  Fly   851 VDFIYKFYHP--LTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTN 913

  Fly  1057 AAWLQRDREQLA 1068
            ..|.:|:..|::
  Fly   914 VQWKERNYHQMS 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	161/402 (40%)
		M1_APN_2	227..667	CDD:189008	181/464 (39%)
		ERAP1_C	742..1052	CDD:288671	75/336 (22%)
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	161/402 (40%)
		M1_APN_2	43..502	CDD:189008	181/463 (39%)
		ERAP1_C	583..908	CDD:288671	75/335 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462105
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850