DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psa and ERAP1

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	927	Identity:	297/927 - (32%)
Similarity:	478/927 - (51%)	Gaps:	75/927 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 QQLEQERKMAQKAKFE----RLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNA 262
            |..|...|.:....|.    |||..|:|.||:||:..||...||.|.|.|::...:||:.|.|::
Human    33 QSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHS 97

  Fly   263 LDIVLDSVELH---FECSKLKPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGF 324
            ..:.:....|.   .|....:|.:::.....|...|...:.:.......:.:.:.|.|::...||
Human    98 HHLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGF 162

  Fly   325 YRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSL 389
            |:|.|....||.|....||||.|.||..|||:||||.||:|.|.:......:|:||||::|..::
Human   163 YKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTV 227

  Fly   390 PDGLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPY 454
            .:||....||.|..|||||||.::.:::.|...:..||.|.|:....|..|..:||:.|..:|.:
Human   228 AEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEF 292

  Fly   455 YKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAH 519
            |:|||:|.|||||.||.||.||.:||||||||.||||:.:|.|.:.:|...|..|.:||.||:||
Human   293 YEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAH 357

  Fly   520 QWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEV 584
            ||||||||||||..||||||:|.|:||:.|....||..:...|....:. |:|:|:|.:|||:..
Human   358 QWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFD-AMEVDALNSSHPVST 421

  Fly   585 PVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAAL---- 645
            ||.:|::|.|:||::||:|||.::.||.:|:..|.|:.|:..||.:|.|.||..||||.::
Human   422 PVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASIC 486

  Fly   646 ---------------QEASSK--------NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQ 687
                           |.:||.        :|..:|.:||..||||::::     :...|.:.:||
Human   487 PTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITI-----TVRGRNVHMKQ 546

  Fly   688 CKFT--ADGSQADENCLWVVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVG 750
            ..:.  :||: .|...||.||::..|||  :.:...||| |:..:| |...:|.:|||.|.|..|
Human   547 EHYMKGSDGA-PDTGYLWHVPLTFITSK--SDMVHRFLL-KTKTDV-LILPEEVEWIKFNVGMNG 606

  Fly   751 YYRTRYSQE-------MLEQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRN 808
            ||...|..:       :|:....||...     ||..||::.|.:|..|..|....|.|....::
Human   607 YYIVHYEDDGWDSLTGLLKGTHTAVSSN-----DRASLINNAFQLVSIGKLSIEKALDLSLYLKH 666

  Fly   809 ETNYTVWTAITNSLTNLHILISHTDLME---DFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRS 870
            ||.........|.|..::.|:...|:.|   .|..|...|...:..:..|  .|..:..:.:|||
Human   667 ETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTW--TDEGSVSERMLRS 729

  Fly   871 LVLTRLVSFRSSDTIEEAKIRFR--RHVNGTELLPADLRTTCYKAVLQ--DGDEKIFNEMLDLYR 931
            .:|...........::.|:..||  :..||...||.|:....:....|  :|.:.::::    |:
Human   730 QLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSK----YQ 790

  Fly   932 ATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSE-VRAQDSVFVIVAVAINPKGRDMAWEFFKE 995
            .:....|:.:|..||....:.:.|:.::|.:...: ::.|:...::..:..||.|..:||:|.::
Human   791 FSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRK 855

  Fly   996 NNKQLLERYQ-GGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIPGCE-RTVSQAVETIRLNAA 1058
            |..:|::::: |...::.::......|::..|.:||:.|....:..|.: |.|.|.:|||..|..
Human   856 NWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIG 920

  Fly  1059 WLQRDREQLAIFLRDDQ 1075
            |:.::.:::.::|:.::
Human   921 WMDKNFDKIRVWLQSEK 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	163/388 (42%)
		M1_APN_2	227..667	CDD:189008	186/469 (40%)
		ERAP1_C	742..1052	CDD:288671	73/326 (22%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	186/470 (40%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	76/329 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53945
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830