DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psa and enpep

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001186660.1	Gene:	enpep / 504088	ZFINID:	ZDB-GENE-050309-218	Length:	951	Species:	Danio rerio

Alignment Length:	898	Identity:	289/898 - (32%)
Similarity:	473/898 - (52%)	Gaps:	69/898 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIV--------------LD 268
            |||..::|.||:|.::|:|....:||...|.:.:.:|:..:.|:..|..              :.
Zfish    80 RLPDYILPFHYDLHMEPDLNTDIYTGDVSVHLKLTQPSQHLWLHIRDTFVTVMPSLQRSSPSGVT 144

  Fly   269 SVELHFECSKLKPEK--IVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFG 331
            ||:|. :|.:.||::  :|.:||..:.|       ..:...||.:.|.|.||..:.||||:.| .
Zfish   145 SVKLK-QCFEYKPQEYVVVEAAEQLSVT-------GPDEHYVLTLHFQGWLNGSLVGFYRTTY-Q 200

  Fly   332 PNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRV 396
            .||..:....|..|.||||:.|||:|||..|||:.|::.......|||||||.|.:.|.:...:.
Zfish   201 ENGVTKKIAATDHEPTDARKSFPCFDEPNKKATYTISITHDSTYKALSNMPVEKTEKLSEQKTKT 265

  Fly   397 RFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNI 461
            .|.::..||||||...|.::|:||..|..|:.:|::....:.....:|.:|...:..|:::||::
Zfish   266 SFMKSVKMSTYLVCFAVHQFDFVERTSKRGIPLRIYAQPLQISTAAYAADVTQVIFDYFEEYFDM 330

  Fly   462 AYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLV 526
            .|.:.|:|.|||.||..||||||||:|||||.:|.|.|.:|.:.||.:|..:.||:.||||||:|
Zfish   331 EYSIQKLDKIAIPDFGTGAMENWGLITYRETNLLFDEKESSSVNKQRVASVIAHELVHQWFGNIV 395

  Fly   527 TMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIW----TQFVTDMYTRALELDSLKNSHPIEVPVG 587
            ||:||..||||||:|||.|::.|..  .|:| |    ...:.|:|...:: |:|.:||||.|.|.
Zfish   396 TMDWWDDLWLNEGFASFFEYIGVEE--AEHD-WGMRDVMLINDVYPVMVD-DALLSSHPIIVDVS 456

  Fly   588 HPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSKN 652
            .|:||..:||.||||||||::|||.|.:|.:|||.|...||..:.:.|..|.|.|.||.:.|...
Zfish   457 SPAEITSVFDAISYNKGASILRMLEDLLGRETFRDGCRRYLKTYLFQNAKTSDFWKALADESGLP 521

  Fly   653 VSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKF----TADGSQADE--NCLWVVPI---S 708
            |:|:|.:||:..|:||:|:.:..|.     .:|.|.:|    .||.||...  ...|.:|:   :
Zfish   522 VADIMDTWTKQMGYPVLSLTNTDTE-----AKLTQTRFLLDPNADPSQPTTPLGYKWTIPVKWKA 581

  Fly   709 VSTSKNPTGIAKTFLLDKSSMEVTLDNVDE--DDWIKINPGTVGYYRTRYSQEM----LEQLMPA 767
            :.::.|      :|:.:|...|..:.....  :..||:|...:|:||..:..:|    .|||:
Zfish   582 LDSTNN------SFIFEKGQTEAVISGYSHATNGLIKVNKDHMGFYRVNHHDQMWSDIAEQLL-- 638

  Fly   768 VEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNL-HILISH 831
            ::.......||...|||:||:.:|......:...|.....:||.|.||..::.|::.: .:|...
Zfish   639 MDHQVYDATDRSSYIDDIFALGRADMVDYGNAFNLTRYLADETEYIVWDRVSASISYVREMLADD 703

  Fly   832 TDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHV 896
            |.|...|.:..|...:.::..|||  :|..|....|||.:||.........:.:::|...|.:.:
Zfish   704 TVLYPLFQKLFRGHVQKISRELGW--KDEGNQTQRLLREIVLGIACQMGDQEALDQASDIFNKWI 766

  Fly   897 NGT-ELLPADLRTTCYK-AVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVI 959
            .|| ..:|.:||...|: .::..|.|:.:..|...|.:..|.:|:|::...|....::.||.|::
Zfish   767 KGTIGSVPVNLRLLVYRYGMMNSGTEESWEIMFQKYLSATLAQEKDKLLYGLASVKNIHLLHRLL 831

  Fly   960 DFAMS-SEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIENFA 1022
            :...: |.:|:||...::..|:.:..|:.|||::...|...|:.||. ....|.||...:...::
Zfish   832 EATKNESIIRSQDVFTLVQYVSRSSDGKIMAWDWMTLNWDYLVNRYTINDRNLGRLPARITTTYS 896

  Fly  1023 SEERAKEVEEFLQVNQIPGC-ERTVSQAVETIRLNAAWLQRDREQLAIFLRDD 1074
            |..:..::|.|..::...|. |....||:||::.|..|::|:::::..:|.::
Zfish   897 SNLQLWKMEHFFALHPNAGAGEMPRKQALETVKNNIEWVERNKDEIRFWLENN 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	156/405 (39%)
		M1_APN_2	227..667	CDD:189008	180/459 (39%)
		ERAP1_C	742..1052	CDD:288671	82/319 (26%)
enpep	NP_001186660.1	Peptidase_M1	80..473	CDD:279741	156/405 (39%)
		M1_APN_2	89..536	CDD:189008	180/459 (39%)
		ERAP1_C	611..927	CDD:288671	82/319 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920