DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and CG11951

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	912	Identity:	290/912 - (31%)
Similarity:	468/912 - (51%)	Gaps:	85/912 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLK---EFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKL 279
            ||||.:.|:.|::.:...|:   :|.|.|...:|:.|.:.|..|||::.|:.:|..|:  ..|::
  Fly    26 RLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEI--TLSQI 88

  Fly   280 KPEKIVYSAENETAT--------LEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGP-NGE 335
            ..|:...:....||.        |...:|:.|.....|.:.|:.:|.|::.|:|||.|... ..|
  Fly    89 GGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANE 153

  Fly   336 ERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIK---EDSLPDGLRRVR 397
            .|:..|||||...||..|||:|||..||:|.|||...|....||||||.:   .:|:||.: ...
  Fly   154 TRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPDYV-WTS 217

  Fly   398 FDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIA 462
            |:.:..|||||||..:.::.:......:|.|.|.:......:|..:|.|:..|||.||::.|.|.
  Fly   218 FEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELFGIK 282

  Fly   463 YPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVT 527
            :||||:|.||:.||||||||||||||:.|:.:|..|:.:|...||..|..|.||:||||||||||
  Fly   283 FPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNLVT 347

  Fly   528 MEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALEL---DSLKNSHPIEVPVGHP 589
            |:|||.||||||:|::|..|||..:.|:   |.....:..:..|.:   |||::||||..|:...
  Fly   348 MKWWTDLWLNEGFATYVASLCVEDIHPQ---WRTLQLESMSNLLTIFRKDSLESSHPISRPIEMT 409

  Fly   590 SEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSK--- 651
            |:|.|.||||||.||:|||||:|.::||:.||.|:..||.::.|.|...::||.:|.:|:.|
  Fly   410 SQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGS 474

  Fly   652 -----NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVST 711
                 |:..:|.|||...|:||::|..:.||:..:|.: ::.....|.|:|.:.|.| ||:|.:.
  Fly   475 LPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQ-ERYLLNTDVSRAHKGCWW-VPLSYTN 537

  Fly   712 SKNPTGIAKTF--LLDKSSMEVT----------LDNVDEDDWIKINPGTVGYYRTRYSQE---ML 761
            .:.     |.|  ...|..||.|          .|....|.|:..|......|:..|..:   :|
  Fly   538 QEE-----KDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLL 597

  Fly   762 EQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLH 826
            .:.:.:.:...:..::|..||||:......|.......|.::.....|.....|.:..::|..:.
  Fly   598 IETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVS 662

  Fly   827 ILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDG--------ENHLDTLLRSLVLTRLVSFRSSD 883
            .::..|.....|..|.|.|..|:     :|..:|        |....|:|:::|.....||..||
  Fly   663 GILRQTPNFRFFKNFTRRLITPI-----YEHLNGINDTVASEEQQDKTILKAIVADWACSFEVSD 722

  Fly   884 TIEEAKIRF----RRHVNGTEL--LPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRI 942
            .:.:| :.|    |...|..|:  :|..:|...|...::.|.::.::.:...|:..::..|:..|
  Fly   723 CVTQA-LSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQII 786

  Fly   943 SRALGCCGDLKLLRRVID--FAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQ 1005
            ..:|||..::.:|:|.::  |....::|.|||..|..|:|.:..|..:|.::..:|...:.:.|.
  Fly   787 LDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYH 851

  Fly  1006 -GGFLLSRLIKYLIENFASEERAKEVEEFLQV-----NQIPGCERTVSQAVETIRLNAAWLQRDR 1064
             ....:|.|:..|.|...::   ::.:||:..     :|:...|:|:||::||:.:|..|.:|:.
  Fly   852 PQSESMSELLPPLSEQIFTQ---RDYDEFMNFMASSKDQLKDIEQTISQSLETMLINVQWKERNY 913

  Fly  1065 EQ 1066
            |:
  Fly   914 ER 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	163/403 (40%)
		M1_APN_2	227..667	CDD:189008	186/465 (40%)
		ERAP1_C	742..1052	CDD:288671	70/334 (21%)
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	184/460 (40%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	72/336 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020