DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and CG31233

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001303538.1	Gene:	CG31233 / 42557	FlyBaseID:	FBgn0051233	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	950	Identity:	281/950 - (29%)
Similarity:	472/950 - (49%)	Gaps:	96/950 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 LAHTSADVIPGQDRHHPGCNYQQIRRAHTQLLSKEQQLEQERK-----MAQKAKFERLPTNVVPR 226
            ::.|.|.|:    |.:|             :|...|.||...:     :|.:..: |||.:.:|.
  Fly    19 ISATQAAVV----RQYP-------------ILDHLQHLENPMQRLVVPLADEDNY-RLPYDTIPS 65

  Fly   227 HYELLLQPNLK--EFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKLK-------PE 282
            ||.:.|..|:.  :..|.|...:.::|...||:|.::|..:.      :|..|.::       .:
  Fly    66 HYAVSLSTNVHTGDTVFNGTVAITLSVLNTTTKIVVHARQLE------NFTASIIQQGVTEAVAQ 124

  Fly   283 KIVYSAENETATLEFAQ---EIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQF 344
            ::||..|.|...|.|::   ..|.:|..:|.:::.|.|.....|||.|.|....|..::...|||
  Fly   125 ELVYEYEAEREFLTFSKTGLTFPEDTTWILTINYQGHLRTDNGGFYLSTYTDEEGNTKYLATTQF 189

  Fly   345 EATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLV 409
            |:||||..|||:|||:.:|.|.||:.......|:|||||  :.|...|:  ..|.:|..|.:|||
  Fly   190 ESTDARHAFPCYDEPSKRAEFTITIKHDPSYNAISNMPV--DSSSTSGV--TVFQKTVNMPSYLV 250

  Fly   410 AVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAIS 474
            |.:|.|:.:.||:. :|:..|||:..|...:..:||.....|......||::.:.|||:|...|.
  Fly   251 AFIVSEFVFSEGEL-NGLPQRVFSRNGTEHEQEWALTTGMLVEKRLSGYFDVPFALPKLDQAGIP 314

  Fly   475 DFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEG 539
            ||:|||||||||.||||.::|.:.:|::...:.:||....||.||.|||:||.:|||:.|||.||
  Fly   315 DFAAGAMENWGLATYREEYLLYNTENSTTSTQTNIATIEAHEDAHMWFGDLVAIEWWSFLWLKEG 379

  Fly   540 YASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKG 604
            :|:..|.|.|...:||:||:..|....|..||..|:..|:.|:...|..||||..::|.:||.|.
  Fly   380 FATLFENLAVDLAYPEWDIFQTFHAGSYQSALVNDASANARPMSHFVQKPSEIALLYDSVSYAKA 444

  Fly   605 ASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEAS-------SKNVSDVMTSWTQ 662
            .||:.|....:....|::|::.||..:|:.......|:.|:.:|:       ...|.|:|.|||.
  Fly   445 GSVLDMWRHALTNTVFQRGLHNYLVDNQFTAANPSKLFEAIAKAAVEENYEVKATVPDMMGSWTN 509

  Fly   663 HKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVSTSKNP---TGIAKTFLL 724
            ..|.|:::|.....:.:   ..:||..:|.|....::. ||.|||:.:.||||   ...|..:||
  Fly   510 QGGVPLLTVTRNYDNGS---FTVKQSVYTNDKDYTNDK-LWYVPINYAESKNPDFRNTEATHYLL 570

  Fly   725 DKSSMEVTL-DNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAV--EKMELPPLDRLGLIDDMF 786
            ::|  |:|: .::|:.:|:.:|..:.||||..|..:..:.:..|:  ...::.|.:|..||:|::
  Fly   571 NQS--EITIYSDLDQTNWLILNKKSTGYYRVLYDAQNYQLITSALITRPHKIDPRNRAQLINDLY 633

  Fly   787 AMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVAY 851
            ....:|....|.:|.|:.....|..|:.|:|....:|.|:..:|......:|..:.|.|......
  Fly   634 RFATSGRVPHATLLELLTYLPQEDQYSPWSATNTVITLLNRYLSGDADYGNFQFYVRELVSLQFD 698

  Fly   852 RLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHV-NGTELLPADLRTTCYKAVL 915
            :.|.....|::||....|::::.........:.:.|...:....| .||::.| :|::..|...|
  Fly   699 KFGVNDNKGDHHLVPFTRNVLINLACLAGLENCLTETTAKLTALVEEGTKIEP-NLQSQVYCNGL 762

  Fly   916 QDGDEK----IFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSE-VRAQDSVFV 975
            :..|:|    :||::|:   :||..|.:..|| ||||..:...|.:.:..::..| :|.|:.:.|
  Fly   763 KQADDKTFDFVFNKLLN---STDQAERRLLIS-ALGCSQNTAQLEKFVYSSIEPEGLRDQERITV 823

  Fly   976 IVAV-AINPKGRDMAWEFFKENNKQLLERY---QGGF-----LLSRLIKYLIENFASEERAKEVE 1031
            :..| :....|..:|.||.::|    .|:|   ..||     |.|.::.  |..:...::.|:..
  Fly   824 LSPVYSRGEVGLLVAIEFLQKN----WEKYGQLNSGFGGVNPLYSDIVG--ISAYTVNDKQKDAL 882

  Fly  1032 EFLQVNQIPGCE---RTVSQAVET-IRLNAAWLQRDREQL 1067
            :.| |:.:.|.|   .|:..:|:: :..|.|||..:|:.|
  Fly   883 QEL-VDTVKGSEYVPSTLQDSVDSNVNANYAWLASNRDPL 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	145/397 (37%)
		M1_APN_2	227..667	CDD:189008	160/458 (35%)
		ERAP1_C	742..1052	CDD:288671	78/329 (24%)
CG31233	NP_001303538.1	Peptidase_M1	57..443	CDD:279741	145/396 (37%)
		M1_APN_2	65..514	CDD:189008	160/459 (35%)
		ERAP1_C	587..905	CDD:288671	78/329 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462120
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.890