DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and npepps

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	874	Identity:	487/874 - (55%)
Similarity:	621/874 - (71%)	Gaps:	22/874 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 MAQKAKFERLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHF 274
            |.::..|.||||:|.|.:|.|.|:|:|.:|||.||....|.|.:.|.||.:|..||  |.:...|
Zfish     1 MPERRPFVRLPTDVYPVNYGLRLKPDLVDFTFEGKLEAAVEVTQGTNQIVMNCADI--DIITASF 63

  Fly   275 ---ECSKLKPEKIVYSAENETATLEFAQEIPAETQ---GVLHMSFTGELNDKMKGFYRSKYFGPN 333
               ...::......|..|:|..||.|    |:..|   |.|.:.|.||||||||||||||| ..:
Zfish    64 VPDGGEEINATGFNYQNEDEKVTLCF----PSTLQKGSGSLKIDFVGELNDKMKGFYRSKY-SSS 123

  Fly   334 GEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLP----DGLR 394
            ||.|:|.|||||||||||.|||||||||||||||||:|||||||||||.|:  |..|    ..|.
Zfish   124 GEVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVV--DRKPYAEDQSLV 186

  Fly   395 RVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYF 459
            .|:|..||||||||||.|:||||:||.:|.|||.|||:|||||.|||.||||||||.||:|||||
Zfish   187 EVKFATTPIMSTYLVAFVIGEYDFVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLPFYKDYF 251

  Fly   460 NIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGN 524
            ::.|||||:|||||:||:|||||||||||||||.:|:||||:....:|.:||.||||:|||||||
Zfish   252 SVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQWFGN 316

  Fly   525 LVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHP 589
            |||||||||||||||:||::|:|||.|.|||||||||||:..|||||:||:|.|||||||.||||
Zfish   317 LVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNSHPIEVDVGHP 381

  Fly   590 SEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSKNVS 654
            ||:|||||.|||:||||||||||:|||::.||||||.||.:.|:.|..|||||..|::||.|.::
Zfish   382 SEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDLWECLEQASGKPIA 446

  Fly   655 DVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENC-LWVVPISVSTSKNPTGI 718
            .||.|||:..|||::.|:.||.. :.|:|::.|.||.|.|.:.||:| .|:||||:.||::|:..
Zfish   447 AVMNSWTKQMGFPIIVVDQEQHG-SDRVLKISQKKFCASGPRNDEDCPNWMVPISICTSEDPSCT 510

  Fly   719 AKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEKMELPPLDRLGLID 783
            ....|||:....|.:.||..|.||||||||||:||.:||..|||.|:|.:..:.|.|:|||||.:
Zfish   511 KTKILLDQPETTVNITNVAPDHWIKINPGTVGFYRIQYSSAMLESLLPGIRDLTLLPVDRLGLQN 575

  Fly   784 DMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEP 848
            |:|::.:||..||.:||.:::::.||.|||||:.::.:|..|..|:||||..||...|.|:|:.|
Zfish   576 DLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSCNLGVLSSLLSHTDFHEDIQEFIRDLFTP 640

  Fly   849 VAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGTELLPADLRTTCYKA 913
            :..:|||:.|.||.|||.|||.|||.:|.......|:|||:.|||.||.|.::|.||||:..|..
Zfish   641 IGMKLGWDSRTGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFREHVEGKQILSADLRSPVYLT 705

  Fly   914 VLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSEVRAQDSVFVIVA 978
            ||:.||....:.||.|::..|:.||::||.|.||......|::||::||:|.|||.||:|.||..
Zfish   706 VLKHGDSTTLDTMLKLHKQADMQEEKNRIERVLGAIPAPDLIQRVLNFALSEEVRPQDTVSVIGG 770

  Fly   979 VAINPK-GRDMAWEFFKENNKQLLERYQGGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIPGC 1042
            ||.:.| ||..||:|.|:|.::|..|||||||:|||||..::.||.::.|.||:.|.:.:..|..
Zfish   771 VAGSSKQGRKAAWKFVKDNWEELHNRYQGGFLISRLIKLTVDGFAIDKMAAEVKSFFESHHAPAA 835

  Fly  1043 ERTVSQAVETIRLNAAWLQRDREQLAIFL 1071
            ||||.|..|.|.||||||:||.:.:..:|
Zfish   836 ERTVQQCCENILLNAAWLKRDADDIHQYL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	256/395 (65%)
		M1_APN_2	227..667	CDD:189008	288/449 (64%)
		ERAP1_C	742..1052	CDD:288671	149/310 (48%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	256/395 (65%)
		M1_APN_2	17..459	CDD:189008	288/450 (64%)
		ERAP1_C	534..845	CDD:288671	149/310 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592299
Domainoid	1	1.000	352	1.000	Domainoid score	I964
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36199
Inparanoid	1	1.050	951	1.000	Inparanoid score	I324
OMA	1	1.010	-	-		QHG53945
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		oto40176
orthoMCL	1	0.900	-	-		OOG6_100948
Panther	1	1.100	-	-	LDO	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2032
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800