DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and LNPEP

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_005566.2	Gene:	LNPEP / 4012	HGNCID:	6656	Length:	1025	Species:	Homo sapiens

Alignment Length:	915	Identity:	295/915 - (32%)
Similarity:	463/915 - (50%)	Gaps:	117/915 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKLKPE 282
            ||||.|||..|||.|.|||...||.|...:.|.    ..|:|.|   |:|.|.  ....|::...
Human   167 RLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQ----ALQVTWN---IILHST--GHNISRVTFM 222

  Fly   283 KIVYSAENETATLEFA----------QEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEER 337
            ..|.|.|.:...||:|          :.:.|.....|.:.::..::....|||...|...:.|::
Human   223 SAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKK 287

  Fly   338 FAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTP 402
            :...||||...||..|||:||||.||||.|.::..:...||||||......|.|||.:..|..:.
Human   288 YFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESV 352

  Fly   403 IMSTYLVAVVVGEYDYVEGKSDD--GVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPL 465
            .|||||||.:|||   ::..|.|  |.||.::....|..|..:|||...|:|.::::||.|.|||
Human   353 KMSTYLVAFIVGE---MKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPL 414

  Fly   466 PKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEW 530
            .|:||:||.||.|||||||||:|:||..:|.|...:|:..::.:...:.||:|||||||||||:|
Human   415 KKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKW 479

  Fly   531 WTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEI 595
            |..||||||:|:|:|:..:..:|.|...:..|: |...:.::.|||.:||||...|....:|:|:
Human   480 WNDLWLNEGFATFMEYFSLEKIFKELSSYEDFL-DARFKTMKKDSLNSSHPISSSVQSSEQIEEM 543

  Fly   596 FDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSK--NVSDVMT 658
            ||.:||.||:|::.||..|:.||.|:..:.|||..|.|.:..::|||.:..|.:::  :|..:|.
Human   544 FDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMK 608

  Fly   659 SWTQHKGFPVVSVESEQTSKNQRLLRLKQCKF----TADGSQADENCLWVVPIS-VSTSKNPTGI 718
            :||..||||:|:|:     |..:.|.::|.:|    ..:...:|.:.||.:|:| |:..:|.:..
Human   609 TWTLQKGFPLVTVQ-----KKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSKY 668

  Fly   719 AKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEKMELPPL-----DR 778
            ....||||.|..:.|  .:|..|:|:|....|||...|:.:..|.|   :.::::.|.     ||
Human   669 QSVSLLDKKSGVINL--TEEVLWVKVNINMNGYYIVHYADDDWEAL---IHQLKINPYVLSDKDR 728

  Fly   779 LGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGR 843
            ..||:::|.:...|.........|::...|| |:|  ..||.:|       ..|||:       .
Human   729 ANLINNIFELAGLGKVPLKRAFDLINYLGNE-NHT--APITEAL-------FQTDLI-------Y 776

  Fly   844 NLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSD-------TIEEAKIRFR-RH----- 895
            ||.|.:.|      .|..:.|.|.:..|:..::.....:|       .:..|.:.|. .|
Human   777 NLLEKLGY------MDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNC 835

  Fly   896 -------------VNGTELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALG 947
                         .|||:.||.|:.||.:|...:  .:|.::.:|..|.:.....|:::|..||.
Human   836 STTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALA 898

  Fly   948 CCGDLKLLRRVIDFAMSSE-VRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQGGFLLS 1011
            ...|::.|..::..:::.: .|.|...|:|..|..:..|..:||:|.|||..:|::::..|
Human   899 SSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLG---- 959

  Fly  1012 RLIKYLIEN--------FASEERAKEVEEFLQVNQIPGC--ERTVSQAVETIRLNAAWLQRDREQ 1066
               .|.|:|        |:::....||:.|.: ||....  .|.|.:|:|.|:||..|::::.:.
Human   960 ---SYTIQNIVAGSTYLFSTKTHLSEVQAFFE-NQSEATFRLRCVQEALEVIQLNIQWMEKNLKS 1020

  Fly  1067 LAIFL 1071
            |..:|
Human  1021 LTWWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	159/397 (40%)
		M1_APN_2	227..667	CDD:189008	176/453 (39%)
		ERAP1_C	742..1052	CDD:288671	82/351 (23%)
LNPEP	NP_005566.2	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding	96..101
		M1_APN_2	175..617	CDD:189008	176/454 (39%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	689..1009	CDD:314669	85/355 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53945
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830