Protein Alignment Psa and erap1b

DIOPT Version :10

• Sequence 1: NP_728614.1
• Gene: Psa / 38175
• FlyBaseID: FBgn0261243
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_956500.2
• Gene: erap1b / 393175
• ZFINID: ZDB-GENE-040426-934
• Length: 963
• Species: Danio rerio
• Alignment Length: 958
• Identity: 298/958 - (31%)
• Similarity: 458/958 - (47%)
• Gaps: 156/958 - (16%)

  Fly   218 RLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVEL---------- 272
            |||..:.|.||.||:.|||....|||...:|:.|.:.|..|.|::.::.:.|..|
Zfish    46 RLPDTISPLHYNLLIHPNLTSLDFTGSVQIQIEVLQDTKTIILHSKNLQISSARLLDANIAQQQP 110

  Fly   273 -------HFECSKLKPEKI------VYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGF 324
                   :|:...|..:|.      |||.|                   ||  |...|::...||
Zfish   111 LKVLEYPYFQQIALVSDKALLKRGHVYSVE-------------------LH--FAANLSESFHGF 154

  Fly   325 YRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSL 389
            |:|.|....|:.|....||||||.||..|||:||||.||.|.:.:......:||||||.::...|
Zfish   155 YKSTYRTSKGDVRVVASTQFEATSARAAFPCFDEPAFKANFSVQIRREAKHIALSNMPKLRTLEL 219

  Fly   390 PDGLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPY 454
            .:||...:||.:..|||||||.:|.::..:...|..||.:.|:....|.:|..|||:.|.|:|.:
Zfish   220 KNGLFEDQFDVSVKMSTYLVAYIVSDFLSISKTSQHGVQISVYAVPEKIDQAEFALDAAVKLLDF 284

  Fly   455 YKDYFNIAYPLPK--------------------MDLIAISDFSAGAMENWGLVTYRETFVLVDPK 499
            |.|||:|.|||||                    :||.||.||.:||||||||.||||:.:|.||.
Zfish   285 YDDYFDIPYPLPKQEKPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRESALLFDPH 349

  Fly   500 NTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVT 564
            .:|...|..|.:.:.||:|||||||||||:||..||||||:|.|:||:.|:...||..:...|:.
Zfish   350 KSSASDKLGITMIIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNPELQVEDYFLG 414

  Fly   565 DMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLT 629
            ..: .|:|:|||.:|||:..||.:|::|.|:||::||:|||.::.||.:::....|:.|:..||.
Zfish   415 KCF-EAMEVDSLSSSHPVSTPVENPAQIQEMFDDVSYDKGACILNMLREFLTPKIFKLGIVKYLK 478

  Fly   630 RHQYGNTCTEDLWAAL-------------------------QEASSK-------NVSDVMTSWTQ 662
            .:.|.||...:||.:|                         ...:||       :|..:|.:||.
Zfish   479 HYSYQNTVNSNLWESLTNVCDSDGLDEGRLKGDESCRHSASNTGASKWHSEDELDVKAMMETWTL 543

  Fly   663 HKGFPVVSVESEQTSKNQRLLRLKQCKF-TADGSQADENCLWVVPISVSTSKNPTGIAKTFLLDK 726
            .:|||::::     :...|.:||.|.:: .:|......:.||.||::..||.:.|  ...||| |
Zfish   544 QEGFPLITI-----AVKGREVRLSQERYLKSDDLSQTSSFLWQVPLTYITSDSTT--VHRFLL-K 600

  Fly   727 SSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVE--KMELPPLDRLGLIDDMFAMV 789
            :..:| |...:|.||||.|....|||...|.....:.|:..::  ...|...||..||::.|.:|
Zfish   601 TKTDV-LYLPEEVDWIKFNVDMSGYYIVHYEGSGWDDLITLLKHNHTALSSNDRASLINNAFQLV 664

  Fly   790 QAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLME---DFHRFGRNLYEPVAY 851
            ..|.......|.|......||.....|...|.|..|:.|:...|::|   ....:...|::.:..
Zfish   665 SVGKLPLDKALDLTLYLSKETEIMPVTQGFNELVPLYKLMEKRDMVELENQMKGYILQLFQKLIE 729

  Fly   852 RLGWEPRDGENHLDTLLRSLVL---------------TRLVS-FRSSDTIEEAKIRFRRHVNGTE 900
            :..|  .|..:..:.:|||.:|               |:|.: :|.||              |..
Zfish   730 QQLW--TDEGSVSERMLRSYLLLFGCVRGHPPCVSNATQLFNLWRDSD--------------GNM 778

  Fly   901 LLPADLRTTCYK--AVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAM 963
            .||.|:....:.  |..:||.:.:|.:    |:.:.....:.||.:||........|:.:::.::
Zfish   779 SLPNDVTMAVFSVGARTEDGWDFLFEK----YKESMYVSMKSRIKQALMTSPLDHKLKWMMEQSL 839

  Fly   964 SSE-VRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIENFASEER 1026
            ..| ::.||..:|:.:|:.|||....||:|.:.|...|::::. |...::.::..:...:::.|.
Zfish   840 EGELIKTQDLPYVVTSVSRNPKAYKHAWDFLQANWDSLIKKFDLGSHSIAHMVVGVTNQYSTREM 904

  Fly  1027 AKEVEEFLQVNQIP--GCE-RTVSQAVETIRLNAAWLQRDREQLAIFL 1071
            ..||..|..:.| |  |.| |.:.||||.|..|..|:.::...|..:|
Zfish   905 LAEVRNFFSLLQ-PETGAELRCIQQAVENIEENIRWMDKNLPLLKAWL 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	M1_APN-Q_like	227..662	CDD:341064	184/509 (36%)
		ERAP1_C	741..1055	CDD:463368	82/341 (24%)
erap1b	NP_956500.2	M1_APN-Q_like	54..543	CDD:341064	184/510 (36%)
		ERAP1_C	614..934	CDD:463368	81/340 (24%)