DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and CG3502

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	252/921 - (27%)
Similarity:	418/921 - (45%)	Gaps:	113/921 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 KAKFE--RLPTNVVPRHYEL--LLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLD----- 268
            :|.:|  |||.:|.|.||.|  |...|..:..|.|...:.:..:|.|..|||:|..:.:|
  Fly    22 RAVYEDYRLPRSVEPLHYNLRILTHLNSTDQRFEGSVTIDLLARETTKNITLHAAYLKIDENRTS 86

  Fly   269 --SVELHFECSKLKPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFG 331
              |.:..|..::::..::     :....|...:|:..:....|.|.|...|||...|:|:|.|..
  Fly    87 VVSGQEKFGVNRIEVNEV-----HNFYILHLGRELVKDQIYKLEMHFKAGLNDSQSGYYKSNYTD 146

  Fly   332 -PNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIK---EDSLPDG 392
             ...|.....||||..|.||:.|||:|||:.||||:|||...|..:.||.|||::   .|||.:
  Fly   147 IVTKEVHHLAVTQFSPTFARQAFPCFDEPSWKATFNITLGYHKKYMGLSGMPVLRCQDHDSLTN- 210

  Fly   393 LRRVRFDRTPIM--STYLVAVVVGEYDYV---EGKSDDGVLVRVFTPVGKREQGTFALEVATKVL 452
              .|..|...::  ||||||..|.:.:..   |.|:.:.|:.|.:.......|...::|:|.|:|
  Fly   211 --YVWCDHDTLLRTSTYLVAFAVHDLENAATEESKTSNRVIFRNWMQPKLLGQEMISMEIAPKLL 273

  Fly   453 PYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEI 517
            .:|::.|.|.:||.|:|.:.:......||||||||||.|..:..:..:....:|.|.|.||.||.
  Fly   274 SFYENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERLPQNQGDYPQKQKDSTAFTVAHEY 338

  Fly   518 AHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPI 582
            |||||||||||.||..|||.||.:::..:|.:..|.||:....:|::.........||......|
  Fly   339 AHQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDLANFFSKDSNATVPAI 403

  Fly   583 EVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQE 647
            ...|.:|:|:...|.|..|.||:..|||||..:||:.|..|:..:|.|..:||....|||.:||.
  Fly   404 SKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFSFGNVAQADLWNSLQM 468

  Fly   648 ASSK--------NVSDVMTSWTQHKGFPVVS-VESEQTSKNQRLLRLKQCKFTAD-GSQADENCL 702
            |:.|        |:|..|.|||...|:|:|: :.:.:|.:    :.|.|.:|..: |.:...:|.
  Fly   469 AALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGE----VTLNQSRFFQEHGIEKASSCW 529

  Fly   703 WV----------------------VPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKIN 745
            ||                      .|::....|.|                  |::..|:|:.:|
  Fly   530 WVPLRFVRQNLPDFNQTTPQFWLECPLNTKVLKLP------------------DHLSTDEWVILN 576

  Fly   746 PGTVGYYRTRYSQE----MLEQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSY 806
            |.....:|..|.:.    ::|.|........:..|::..|:||:.|:.............|::..
  Fly   577 PQVATIFRVNYDEHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYL 641

  Fly   807 RNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVAYRLGWEPR-DGENHLDTLLRS 870
            :.|.::..|......|..|..|::..: ...|..:.:.|..|:..|.   |: .|.......::.
  Fly   642 KKEQDFLPWQRAIGILNRLGALLNVAE-ANKFKNYMQKLLLPLYNRF---PKLSGIREAKPAIKD 702

  Fly   871 L-----VLTRLVSFRSSDTIEEAKIRFRRH-VNGTELLPADLRTTCYKAVLQDGDEKIFNEMLDL 929
            :     ..::...:..:|..::|||....| ..|...||:|.:...|.::|.:|.:..|.|:..|
  Fly   703 IPFAHFAYSQACRYHVADCTDQAKILAITHRTEGQLELPSDFQKVAYCSLLDEGGDAEFLEVFGL 767

  Fly   930 YRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSEVR-AQDSVFVIVAVAIN--PKGRDMAWE 991
            ::.:....::..::.||||..:.....:.:::.:.|:.: ..|...:.|..|:|  |.....| .
  Fly   768 FQNSTNGSQRRILASALGCVRNFGNFEQFLNYTLESDEKLLGDCYMLAVKSALNREPLVSPTA-N 831

  Fly   992 FFKENNKQLLERYQ----GGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIPGCERTVSQAVET 1052
            :...:.|:|.|:::    .|.|||     |.:|..|.|....::  .|:..:...|..:.:|:..
  Fly   832 YIISHAKKLGEKFKKKELTGLLLS-----LAQNLRSTEEIDRLK--AQLEDLKEFEEPLKKALYQ 889

  Fly  1053 IRLNAAWLQRD 1063
            .::|..| |:|
  Fly   890 GKMNQKW-QKD 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	138/403 (34%)
		M1_APN_2	227..667	CDD:189008	162/465 (35%)
		ERAP1_C	742..1052	CDD:288671	63/327 (19%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	138/403 (34%)
		M1_APN_2	37..496	CDD:189008	162/466 (35%)
		ERAP1_C	573..890	CDD:288671	63/328 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462108
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850