DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and Trhde

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001102461.1	Gene:	Trhde / 366894	RGDID:	728895	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	1076	Identity:	310/1076 - (28%)
Similarity:	532/1076 - (49%)	Gaps:	140/1076 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 KQQNPKPSGAADKTTSVKHLFRAESGHLNALI--------------------SSKQFVKVQKQFY 136
            |::..|....|:|::|.   |.|..|..:|.:                    ::::.:.|.|:..
  Rat    21 KKRKKKEEEGAEKSSSP---FAATMGEDDAALRASGRGLSDPWADSVGVRPRTTERHIAVHKRLV 82

  Fly   137 RDFS-------SVSLGAPLKSSDAPLLGDLCSQYRAILAHTSADVIPGQD--------------- 179
            ..|:       :|::.|.|.|    |..|.|.         ::..:||.|
  Rat    83 LAFAVSIVALLAVTMLAVLLS----LRFDECG---------ASAAMPGTDGGLGGFPERGGNSSY 134

  Fly   180 ------RHHPGCNYQQ-----IRRAHTQLLSKEQQLEQERKMAQKAKFERLPTNVVPRHYELLLQ 233
                  .||.|....|     :..|.|.  |.....|:|::..|.....||..::.|.||.|:|.
  Rat   135 PGSARRNHHAGEESSQREIGEVGTAGTP--SAHPPSEEEQEQWQPWTQLRLSGHLKPLHYNLMLT 197

  Fly   234 PNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKLKPEKIVYSA---------- 288
            ..::.|||:|:..|::..:..|..:.|:|..:.::.|::        .|...:.|
  Rat   198 AFMENFTFSGEVNVEIACQNATRYVVLHASRVAVEKVQV--------AEDRAFGAVPVAGFFLYP 254

  Fly   289 ENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRCF 353
            :.:...:...:.:.|:....|.:.:...:.:::.||:||.|. .:||.||.|||||..|.||:.|
  Rat   255 QTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYV-IHGERRFLGVTQFSPTHARKAF 318

  Fly   354 PCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLVAVVVGEYDY 418
            ||:|||..||||.|::......::||||||.......||.....|.:||:||||.:|..:..:.|
  Rat   319 PCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTY 383

  Fly   419 VEGKSDDGVLVRVFT--PVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAM 481
            .|..:..||:||::.  ...:|..|.:||.:..:::.:|:|||.:.|.|||:||:|:......||
  Rat   384 RETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAM 448

  Fly   482 ENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEF 546
            |||||..:.|..:|:||..:|:.....:.:.:.|||.|||||:|||..||..:||.||:|.:.||
  Rat   449 ENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEF 513

  Fly   547 LCVHHLFPEYDIWTQ-FVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRM 610
            :...:|:|.:::..| |:||:....:.||.|.:|||:...|...::||::||.|:|.|||::|||
  Rat   514 VGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDKVFDWIAYKKGAALIRM 578

  Fly   611 LHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSK-----NVSDVMTSWTQHKGFPVVS 670
            |.:::|...|::|:..|||.|:|||....|||..|.||..:     |:.:||..||...|:||::
  Rat   579 LANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVIT 643

  Fly   671 VESEQTSKNQRLLRLKQCKFTAD-GSQA------DENCLWVVPISVSTSKNPTGIAKTFLL--DK 726
            :....|::|:.|  :.|..|..| |::.      :.:.||.:|:::... |.:.::...::  ..
  Rat   644 ILGNMTAENRIL--ITQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVG-NRSHVSSEAIIWVSN 705

  Fly   727 SSMEVTLDNVDEDDWIKINPGTVGYYRTRYS----QEMLEQLMPAVEKMELPPLDRLGLIDDMFA 787
            .|....:..:|:..||..|....||:|..|.    :.:::||:...|.:.:.  :|.|||||.|:
  Rat   706 KSEHHRITYLDKGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVS--NRAGLIDDAFS 768

  Fly   788 MVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVA-- 850
            :.:||:......|.::.....|.::..|.|.:.:|..|..|:   |.||:::.|...:.:.||
  Rat   769 LARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLL---DRMENYNIFNEYILKQVATT 830

  Fly   851 -YRLGWEPRDGEN---------HLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGT-ELLPA 904
             .:||| |::..|         |.:  ||..|:....||.:....::|.......::.. ..:|.
  Rat   831 YSKLGW-PKNNFNGSVVQASYQHEE--LRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPL 892

  Fly   905 DLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSE-VR 968
            ::|...|...:...||.::..:...:.:|....|:..:..||.|..|..||.|:::.:::|| |.
  Rat   893 NVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVL 957

  Fly   969 AQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERY-QGGFLLSRLIKYLIENFASEERAKEVEE 1032
            .||::.||:.||.||.|||:||:||::..|.|..|| :..|:.|:||..:.|...:|...||::.
  Rat   958 DQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKN 1022

  Fly  1033 FLQVNQIPG-CERTVSQAVETIRLNAAWLQRDREQL 1067
            |::  ...| ...:.|:||||:..|..|.:..:::|
  Rat  1023 FMK--SYDGVASASFSRAVETVEANVRWKRLYQDEL 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	136/398 (34%)
		M1_APN_2	227..667	CDD:189008	162/457 (35%)
		ERAP1_C	742..1052	CDD:288671	92/329 (28%)
Trhde	NP_001102461.1	M1_APN-Q_like	190..635	CDD:341064	160/453 (35%)
Trhde	NP_001102461.1	ERAP1_C	720..1044	CDD:403137	95/333 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820