DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and CG40470

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001036635.1	Gene:	CG40470 / 3355093	FlyBaseID:	FBgn0058470	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	957	Identity:	217/957 - (22%)
Similarity:	390/957 - (40%)	Gaps:	176/957 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLKEFTFTGK------------------------TVVQVNVKEPTTQI 258
            |||..|:|..||:|::|::....|.|.                        .|.|:|:      .
  Fly    52 RLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINL------T 110

  Fly   259 TLNALDIVLDSVELHFECSKLKPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKG 323
            |||..|..||...:.....:| |.|.|:       .|....:|...::.:|.:.|.|.:::..:|
  Fly   111 TLNMGDGTLDKNVIILRGVRL-PRKPVF-------VLYLKDKIKKGSECLLDIYFQGNISETEEG 167

  Fly   324 FYRSKY--FGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKE 386
            .:||.|  .|.:|||.:. .|..:..:|||.|||:|||.||..|::::..||..:.|.|.|:...
  Fly   168 LFRSYYTNSGNDGEEIYL-ATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNT 231

  Fly   387 DSLPDGLRRVRFD---RTPIMSTYLVAVVV------GEYDYVEGKSDDGVLVRVFTPVGKREQGT 442
            .:.|. ||....|   .|..|||:....|:      .|:..|  ||.|...:.:::   .....|
  Fly   232 INHPK-LRSYSLDFFHTTAPMSTHAFGFVILKLHMWNEHKIV--KSSDIPAINIWS---NNLSST 290

  Fly   443 FALEVATKVLPYY---KDYFNIAYPLPKMDLIAISD------FSAGAMENWGLVTYRETFVLVDP 498
            ..|::..|:...:   :.:|||..||.|:|:|||..      .||.     |::..||:.:|
  Fly   291 NLLDIQNKLNVAHTTIQHFFNIPLPLTKLDVIAIPSLATLPFISAS-----GILIARESEIL--- 347

  Fly   499 KNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHL---------FP 554
                   |:.: ..:..|:.:||.|..:|.||||...:|:...||:....|..:         :|
  Fly   348 -------KKDV-FEISRELIYQWIGIWITPEWWTDANVNKALISFIASEIVFEINGGIEFNGKYP 404

  Fly   555 EYDIWTQFVTDMYTRALELDS-LKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGED 618
                    :|.:|:...||.. ..|||           |..|..|.:..|...:||||...:|:.
  Fly   405 --------MTILYSLYYELSKRYPNSH-----------ITGIKHEFASIKVQLIIRMLSLTVGKY 450

  Fly   619 TFRKGMNLYLTRHQYGNTCTEDLWAAL-QEASSKNVSD-------VMTSWTQHKGFPVVSV---- 671
            |||.|:..::..:::....:.|.|.|: .:|.:.|..|       :..||.:|...|:|::
  Fly   451 TFRLGIQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDY 515

  Fly   672 ESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISV----STSKNPTGIAKTFLLDKSSMEVT 732
            :||.....|::...::.....|    .:|.||.:||::    |.|...||   :|.....:.::.
  Fly   516 DSETAIVQQKVYLRERLHDVPD----QDNMLWWIPIALKRQDSLSFVNTG---SFKWMNKTRQML 573

  Fly   733 LDNV-DEDDWIKINPGTVGYYRTRYSQ---EMLEQLMPAVEKME-LPPLDRLGLIDDMFAMVQAG 792
            :.|: .::.:|.:|...:|.:...|..   .||.:.:...||.| :|...|..|:.|.:.:..||
  Fly   574 ISNLPSKNMFIIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAG 638

  Fly   793 HASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVAYRLGWEP 857
            ..:.:..|.:....:.|.|:.||:.:...|..:...:..:.:.:.|..:...|..|:...||...
  Fly   639 ELNFSTALNVTLFLKYERNHIVWSPVFTFLDQVGKRLEKSSINKKFELYIIELLAPLYEYLGTAH 703

  Fly   858 RDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGT----ELLPADLRTTCYKAVLQDG 918
            .:.:.:: |.||.|..:.|.........:||:..|...:|.:    | .|......|  ::.:.|
  Fly   704 FNEDINI-TELRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFE-TPVPNEYIC--SIFKWG 764

  Fly   919 DEKIFNEMLDLYRATDLHE---EQDR---ISRALGCCG---------DLKLLRRVIDFAMSSEVR 968
            ..|.:  |..|.|..:..:   :.||   :....||..         :|.:|:.:..|:.:
  Fly   765 SMKEW--MFGLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDT---- 823

  Fly   969 AQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLER-YQGGFLLSRLIKYLIENFASEERAKEVEE 1032
              |.:.:|..|.....|.....:|...|...:..: |....:.::||......|:::|....|::
  Fly   824 --DKMLIISTVTSRSIGYTTLLDFLSNNWDDIHHKFYNNTNIWTKLISSATGMFSTQEGYDLVKK 886

  Fly  1033 FL--QVNQIPGCERTVSQAVETIRLNAAWLQRD----REQLAIFLRD 1073
            |.  ........:..:.:::..|:....|.:::    .|.:..:|.|
  Fly   887 FYDEHYGHFGRAQHIIEKSLRNIKEGIQWSKQNIPVIEEWIDHYLSD 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	113/439 (26%)
		M1_APN_2	227..667	CDD:189008	127/501 (25%)
		ERAP1_C	742..1052	CDD:288671	63/335 (19%)
CG40470	NP_001036635.1	GluZincin	60..503	CDD:301352	126/498 (25%)
CG40470	NP_001036635.1	ERAP1_C	584..906	CDD:288671	63/333 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920