DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and CG31343

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	267/895 - (29%)
Similarity:	439/895 - (49%)	Gaps:	59/895 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLK--EFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKLK 280
            |||....|..|.:.|..|:.  :..|.|...:.:.|...|:.|||:...      ..:||.:.:.
  Fly    57 RLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQ------TSNFEATIIS 115

  Fly   281 PEKIVYSAENETATLEFAQE------------IPAETQGVLHMSFTGELNDKMKGFYRSKYFGPN 333
            .:....:|...|.|.|..:|            ..|.|...:.:::||.....|.|||.|.|...:
  Fly   116 RDVATPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDD 180

  Fly   334 GEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRF 398
            ||:.|...||||:|:||..|||:||||.:|.|.||:.......|:||||| ...:...|:  ..|
  Fly   181 GEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPV-NTAATSSGV--TAF 242

  Fly   399 DRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAY 463
            ..||.|||||||.:|.:::...|:. :|:..|||:..||::|..:||.....|......||.:.:
  Fly   243 QTTPKMSTYLVAFIVSDFESTTGEL-NGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPF 306

  Fly   464 PLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTM 528
            .|||:|...|.||||||||||||.||||.::..:.:|:::..|.:||..:|||.||.|||:||::
  Fly   307 ALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSI 371

  Fly   529 EWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEID 593
            :|||:|||.||:|:...:......||.:|.:..|..:.|..||..|:|.::.|:...|..||||.
  Fly   372 KWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEIS 436

  Fly   594 EIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTE-DLWAALQEASSK------ 651
            ..::..||.|.|||:.|..:...:..||.|:|.|||::|| .:|.| ||:|:.||::.:
  Fly   437 NRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQY-TSCDEWDLFASFQESADELGFTLP 500

  Fly   652 -NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADEN-CLWVVPISVSTSK- 713
             :|.|:.:||:...|:|:::|   ..:.|...:.:.|.::.|  ::.|.| ..|.||::.:|:.
  Fly   501 ASVDDIFSSWSHQAGYPLLTV---TRNYNAGTITITQKRYVA--NKTDTNSATWYVPLNFATANK 560

  Fly   714 ---NPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEKM--EL 773
               ..|. |..:||:.:...::......||||.:|....|||||.|..:....:..|::..  ..
  Fly   561 YDYRDTS-ATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRF 624

  Fly   774 PPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDF 838
            .|.:|..|:.|.:..|.....|.:.:|.|:....||..|..|:.....||.....:...|...:|
  Fly   625 HPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNF 689

  Fly   839 HRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHV-NGTELL 902
            ..|.:.|.:|:..::|.....||::|:..||.::::......|.|...::..:...:: ||| .:
  Fly   690 QDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGT-AI 753

  Fly   903 PADLRTTCYKAVLQDGDEKIFNEM-LDLYRATDLHEEQDRISRALGCCGD----LKLLRRVIDFA 962
            .|.|:|..|.|.|:....:|::.: .||..::|..:....|| :|||.|.    |..||..:|..
  Fly   754 EATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFIS-SLGCSGSTSQLLDFLRLSLDTN 817

  Fly   963 MSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQGGFLLSRLIKYLIENFASEERA 1027
            .|.....:.|: :..|.:.:..|...:.||.:.|.:...........|...::.:.....||::.
  Fly   818 NSLSYSERTSL-LNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQK 881

  Fly  1028 KEVEEFLQVNQIPG---CERTVSQAVET-IRLNAAWLQRDREQLAIFLRD 1073
            ..:...:.|.:..|   ....:|..::: |..|.|||:.:|:.:..::.|
  Fly   882 TRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIED 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	144/399 (36%)
		M1_APN_2	227..667	CDD:189008	166/461 (36%)
		ERAP1_C	742..1052	CDD:288671	72/320 (23%)
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	144/398 (36%)
		M1_APN_2	65..517	CDD:189008	166/462 (36%)
		ERAP1_C	591..886	CDD:288671	69/297 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462118
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	9	8.800