Protein Alignment Psa and anpepb.1

DIOPT Version :10

• Sequence 1: NP_728614.1
• Gene: Psa / 38175
• FlyBaseID: FBgn0261243
• Length: 1075
• Species: Drosophila melanogaster
• Sequence 2: NP_001082794.1
• Gene: anpepb.1 / 322533
• ZFINID: ZDB-GENE-030131-1253
• Length: 965
• Species: Danio rerio
• Alignment Length: 957
• Identity: 306/957 - (31%)
• Similarity: 497/957 - (51%)
• Gaps: 105/957 - (10%)

  Fly   194 HTQLLSKEQQLEQERKMAQKAKFE---------------------RLPTNVVPRHYELLLQPNLK 237
            ::|..||..::|.::....|....                     |||..:.|..|::.|.|.|:
Zfish    33 YSQEKSKNNEIENQQTTTTKGPTTNVPATTNIPTTVPSNEPWDQWRLPQTLSPETYKVTLWPRLQ 97

  Fly   238 E-----FTFTGKTVVQVNVKEPTTQITLNALDIVL-DSVEL---------HFECSKLKPEKIVYS 287
            :     :.|||.:.|.....|.|..|.:::..:.: ||..|         :...:|:.| |..|.
Zfish    98 KNAEGLYIFTGDSSVVFRCVENTDLILIHSNKLTIKDSTTLKALGGNPAPNIVSTKMYP-KTQYM 161

  Fly   288 AENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRC 352
            |      :...:|:.|.....|:..|.|||:|.:.|||||:|:..||..:....||.:|||||:.
Zfish   162 A------IWLDRELTAGESYELYTEFVGELSDDLGGFYRSEYYDENGVLKVVATTQMQATDARKA 220

  Fly   353 FPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLP---DG--LRRVRFDRTPIMSTYLVAVV 412
            |||:||||:||.|:|.|:.....|||||..||:|  :|   ||  |.:..|..|..|||||:|.:
Zfish   221 FPCFDEPAMKAVFNIVLLHDPGTVALSNGVVIEE--IPVTVDGISLTKTTFAPTEKMSTYLLAFI 283

  Fly   413 VGEYDYVEGKSDDGVLVRVFTPVGKRE-----QGTFALEVATKVLPYYKDYFNIAYPLPKMDLIA 472
            |.|:.|:|.|.|| :.:|:|   .::|     ||.:||.|..|:|.::::|:|.:|||||.|.||
Zfish   284 VSEFTYIEQKLDD-LQIRIF---ARKEAIDANQGEYALSVTGKILRFFEEYYNSSYPLPKSDQIA 344

  Fly   473 ISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLN 537
            :.||:|||||||||:|||||.:|.|.:.:|...|:.:...:.||:||||||||||:.||..||||
Zfish   345 LPDFNAGAMENWGLITYRETALLYDEEMSSNGNKERVVTVIAHELAHQWFGNLVTIRWWNDLWLN 409

  Fly   538 EGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPI---EVPVGHPSEIDEIFDEI 599
            ||:||:||:|......|.::|....|.:...|...:|:|.:|||:   |..|..|.:|.|:||.|
Zfish   410 EGFASYVEYLGADEAEPLWNIKDLIVLNDVHRVFAIDALASSHPLSSKEEDVQRPEQISEVFDTI 474

  Fly   600 SYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASS-------KNVSDVM 657
            ||:|||||:|||.:::.||.|.:|:..||...::.||...|||..||.|..       ::|.|:|
Zfish   475 SYSKGASVLRMLSNFLSEDVFTQGLRTYLEHFKFNNTVYTDLWDHLQMAVDETGTELPRSVKDIM 539

  Fly   658 TSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADE----NCLWVVPISVSTSKNPTGI 718
            ..|....|||||::       |....::.|..|..|.....|    |..|.|||  :.:||....
Zfish   540 DRWVLQMGFPVVTI-------NTVTGQISQEHFLLDPETKPEPSEFNYEWFVPI--TWTKNEAIK 595

  Fly   719 AKTFLLDKSSMEVTLDNV--DEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVE--KMELPPLDRL 779
            .:.:||.|::.   .|::  :.::|:..|..||||||..|.::..|:|:.|::  :..:|.::|.
Zfish   596 PQYWLLQKNTQ---FDDMKTNANEWVLANINTVGYYRVNYDEQNWERLLNALQTSRESIPVINRA 657

  Fly   780 GLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRN 844
            .||||.|.:.:||...|...|...:....||.|..|.:..|:|...:::...:::......:.|.
Zfish   658 QLIDDAFNLAKAGIIKTTLALRTTEFLDVETEYMPWQSALNNLDYFYLMFDRSEVYGHMQAYIRK 722

  Fly   845 ----LYEPVAYRLGWE--PRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGTELLP 903
                |:|.......|:  |   :||.:...:...|....|....:..:.....|...:|..::.|
Zfish   723 QVTPLFEYFTELTDWQGVP---DNHTEQYNQVNALRVACSIGLKNCTDLVTSWFGEWMNNEDVNP 784

  Fly   904 --ADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAM-SS 965
              |:||:|.|.:.:..|..:.:.....::..|.:..|:|::..|:.|.....||.|.:::.: ::
Zfish   785 IHANLRSTVYCSAIAAGGAEEWEFAWKMFEKTSVASEKDKLRAAMACATQPWLLNRYLEYTLDAN 849

  Fly   966 EVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQGG-FLLSRLIKYLIENFASEERAKE 1029
            ::|.||:...||::|.|..|:.:||:|.:.|.:.:..:|.|| |..|.||..:.:.|::|...|:
Zfish   850 KIRKQDATSTIVSIASNVGGQSLAWDFVRANWEYIFNQYGGGSFSFSNLINGVTKRFSTEFELKQ 914

  Fly  1030 VEEFLQVNQIPGC---ERTVSQAVETIRLNAAWLQRDREQLAIFLRD 1073
            :.:|.:.|:..|.   ...:.|::|..:.|..|:::::..:..:.:|
Zfish   915 LMQFKEDNEHIGFGSGSLAIQQSIERTKANIKWVEQNKADVLQWFKD 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	M1_APN-Q_like	227..662	CDD:341064	191/469 (41%)
		ERAP1_C	741..1055	CDD:463368	82/328 (25%)
anpepb.1	NP_001082794.1	M1_APN-Q_like	88..544	CDD:341064	191/468 (41%)
		ERAP1_C	617..943	CDD:463368	82/328 (25%)