DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and CG31198

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	914	Identity:	277/914 - (30%)
Similarity:	461/914 - (50%)	Gaps:	80/914 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 AHTQLLSKEQQLEQERKMAQKAKFERLPTNVVPRHYELLLQPNL------KEFTFTGKTVVQVNV 251
            |.|:.||.:  ::....:|.:....||..::.|.:|.:.|:|.|      |.|||.|:..::|..
  Fly    19 AGTRQLSVD--VQPPATLATELNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVIS 81

  Fly   252 KEPTTQITLNALDIVLDSVELHFE---CSKLKPEKIVYSAENET------ATLEFAQEIPAETQG 307
            .:.|..|.|::.::.. ||..:::   .....|..|..||.|.|      ..|..:..:.|.|..
  Fly    82 NQTTNDIYLHSKNLTY-SVREYWQKPTTEVANPTVIQISATNTTNYDTDIVKLTASTALTANTTY 145

  Fly   308 VLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVP 372
            :||..:||.:.|.|.|||||.|...|...::.|.|||:...|||.||.:|||..|||||:||...
  Fly   146 ILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRH 210

  Fly   373 KDRVALSNMPVIKE-DSLPDGLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDD-GVLVRVFTPV 435
            :...::||..:|.. .|..:|:....:..||.|||||:|.::.|  :|..|.|| ||..|.....
  Fly   211 RTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISE--FVARKDDDFGVYARPEYYA 273

  Fly   436 GKREQGTFALEVATKVLPYY-KDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPK 499
            ..:......:::..::..|. |||:::..  .|||:.||.||||||||||||:||||..:|||..
  Fly   274 QTQYPYNVGIQILEEMGQYLDKDYYSMGN--DKMDMAAIPDFSAGAMENWGLLTYRERSLLVDES 336

  Fly   500 NTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVT 564
            .|:|..:||||..|.||.||.|||:|||.:||::.|||||:|.:.::.....:..::::..|||.
  Fly   337 ATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVV 401

  Fly   565 DMYTRALELDSLKNSHPI-EVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYL 628
            |.....:.:||...::|: :.....|:.:..:|:.|||||||:.|||:...:||..|:|.:..||
  Fly   402 DQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYL 466

  Fly   629 TRHQYGNTCTEDL---WAALQEASSKNVS--DVMTSWTQHKGFPV--VSVESEQTSKNQRLLRLK 686
            .:::|.::..|.|   |.|....||.|.|  |:..|:|:..|:|:  |:|.:.|.|..|:...||
  Fly   467 KKYEYQSSLPEYLLGAWQANWPNSSYNESSKDIFKSFTEQVGYPLINVTVGNSQVSFTQKRFLLK 531

  Fly   687 QCKFTADGSQADENCLWVVPISVSTSKNPTGIAKT--FLLDKSSMEVTLDNVDEDDWIKINPGTV 749
            :    :|||  |.:..:.||||.:||:....:..|  |:| |.::..|:.......||.:|....
  Fly   532 E----SDGS--DSSLKYTVPISYTTSETNNFLNTTPKFIL-KPNVTTTVQFNSTIKWIVVNIQQT 589

  Fly   750 GYYRTRYSQEMLEQLMPAVEKME---LPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETN 811
            ||||..||.:....:..|:....   :...:|..::||:|.:.:||:.:....|.:::..:.|||
  Fly   590 GYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETN 654

  Fly   812 YTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRL 876
            |..||:..|....|.|.:.:.  ..||:.:.:.|......:||:.....:..||..||:.:|:..
  Fly   655 YIPWTSAFNGFNYLTIRLGND--TADFNYYIQTLTNKAYNQLGFNEASNDTALDIYLRTKILSWA 717

  Fly   877 VSFRSSDTIEEAKIRFRRHVNGTELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDR 941
            ..:.|||.|.:|:..|:    ....:|.::|.|.|...|::|.|..|..:.:.::...:..|:..
  Fly   718 CRYGSSDCISQAQGYFQ----SLATVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETL 778

  Fly   942 ISRALGCCGDLKLLRRVIDFAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQ------- 999
            :..:.||.....|:.:|.|..:|.|:|.||...|:..:             :.|||:.
  Fly   779 LQNSFGCVKTQSLIEKVFDLIISDEIRRQDKSSVLATL-------------YTENNENVSPVFAL 830

  Fly  1000 LLERYQ------GGF-LLSRLIKYLIENFASEERAKEVEEFLQVN--QIPGCERTVSQAVETIRL 1055
            :.::|:      ||: .::.:|..:...|.:.::..::|.|.:.|  :....:.|::.|..|::.
  Fly   831 VTQKYEELAEAMGGYSAVATVISNIAARFTTNQQLTDLENFNKANGAKFGSSQATLTAAEATVKE 895

  Fly  1056 NAAW 1059
            |..|
  Fly   896 NLEW 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	146/404 (36%)
		M1_APN_2	227..667	CDD:189008	168/463 (36%)
		ERAP1_C	742..1052	CDD:288671	74/328 (23%)
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	146/404 (36%)
		M1_APN_2	50..510	CDD:189008	168/464 (36%)
		ERAP1_C	582..898	CDD:288671	76/334 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.920