DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and TRHDE

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	1060	Identity:	310/1060 - (29%)
Similarity:	528/1060 - (49%)	Gaps:	109/1060 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 KQQNPKPSGAADKTTSVKHLFRAESGHLNALI--------------------SSKQFVKVQKQFY 136
            |::..:....|:|::|.   |.|..|..:|.:                    ::::.:.|.|:..
Human    25 KKEEEEEEEGAEKSSSP---FAAAMGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLV 86

  Fly   137 RDFSSVSLGAPLKSSDAPLLGDLCSQYRAILAHTSAD-------------VIPGQDR--HHPGCN 186
            ..| :|||.|.|..:...:|..|........|...||             .:||..|  ||.|.:
Human    87 LAF-AVSLVALLAVTMLAVLLSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGD 150

  Fly   187 YQQIRR---AHTQLLSKEQQLEQERKMAQKAKFERLPTNVVPRHYELLLQPNLKEFTFTGKTVVQ 248
            ..|...   |.....|.:...|:||:..:.....||..::.|.||.|:|...::.|||:|:..|:
Human   151 SWQPEAGGVASPGTTSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVE 215

  Fly   249 VNVKEPTTQITLNALDIVLDSVELHFECSKLKPEKIVYSA----------ENETATLEFAQEIPA 303
            :..:..|..:.|:|..:.::.|:|        .|...:.|          :.:...:...:.:.|
Human   216 IACRNATRYVVLHASRVAVEKVQL--------AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDA 272

  Fly   304 ETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDIT 368
            :....|.:.:...:.:::.||:||.|. .:||.||.|||||..|.||:.|||:|||..||||.|:
Human   273 QRNYNLKIIYNALIENELLGFFRSSYV-LHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKIS 336

  Fly   369 LVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFT 433
            :......::||||||.......||.....|.:||:||||.:|..:..:.|.|..:..||:||::.
Human   337 IKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYA 401

  Fly   434 --PVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLV 496
              ...:|..|.:||.:..:::.:|:|||.:.|.|||:||:|:......|||||||..:.|..:|:
Human   402 RPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILL 466

  Fly   497 DPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQ 561
            ||..:|:.....:.:.:.|||.|||||:|||..||..:||.||:|.:.||:...:|:|.:::..|
Human   467 DPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQ 531

  Fly   562 -FVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMN 625
             |:||:....:.||.|.:|||:...|...::||.:||.|:|.|||::||||.:::|...|::|:.
Human   532 RFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQ 596

  Fly   626 LYLTRHQYGNTCTEDLWAALQEASSK-----NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRL 685
            .|||.|:|||....|||..|.||..:     |:.:||..||...|:||:::....|::|:  :.:
Human   597 DYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENR--III 659

  Fly   686 KQCKFTADGSQ-------ADENCLWVVPISVSTSKNPTGIAKTFLL--DKSSMEVTLDNVDEDDW 741
            .|..|..|.|.       .:.:.||.:|:::... |.:.::...::  ...|....:..:|:..|
Human   660 TQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVG-NRSHVSSEAIIWVSNKSEHHRITYLDKGSW 723

  Fly   742 IKINPGTVGYYRTRYS----QEMLEQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLAL 802
            :..|....||:|..|.    :.:::||:...|.:.:.  :|.|||||.|::.:||:......|.:
Human   724 LLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVS--NRAGLIDDAFSLARAGYLPQNIPLEI 786

  Fly   803 VDSYRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVA---YRLGWEPRDGEN-- 862
            :.....|.::..|.|.:.:|..|..|:   |.||:::.|...:.:.||   .:||| |::..|
Human   787 IRYLSEEKDFLPWHAASRALYPLDKLL---DRMENYNIFNEYILKQVATTYIKLGW-PKNNFNGS 847

  Fly   863 -------HLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGT-ELLPADLRTTCYKAVLQDGD 919
                   |.:  ||..|:....||.:....::|.......::.. ..:|.::|...|...:...|
Human   848 LVQASYQHEE--LRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLD 910

  Fly   920 EKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSE-VRAQDSVFVIVAVAINP 983
            |.::..:...:.:|....|:..:..||.|..|..||.|:::.:::|| |..||::.||:.||.||
Human   911 EDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNP 975

  Fly   984 KGRDMAWEFFKENNKQLLERY-QGGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIPGCERTVS 1047
            .|||:||:||::..|.|..|| :..|:.|:||..:.|...:|...||::.|:: |.......:.|
Human   976 HGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMK-NYDGVAAASFS 1039

  Fly  1048 QAVETIRLNAAWLQRDREQL 1067
            :||||:..|..|....:::|
Human  1040 RAVETVEANVRWKMLYQDEL 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	137/398 (34%)
		M1_APN_2	227..667	CDD:189008	163/457 (36%)
		ERAP1_C	742..1052	CDD:288671	91/328 (28%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	161/453 (36%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	94/332 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820