DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and ape2

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_595998.1	Gene:	ape2 / 2540648	PomBaseID:	SPBC1921.05	Length:	882	Species:	Schizosaccharomyces pombe

Alignment Length:	869	Identity:	301/869 - (34%)
Similarity:	501/869 - (57%)	Gaps:	20/869 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 LPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECSKLKPEK 283
            ||.||.|.||:|.|.|:|:.||:.||.||.::|.|.:..|||:.:::.:.:..|.:....:...:
pombe    20 LPKNVKPIHYDLSLYPDLETFTYGGKVVVTLDVLEDSNSITLHGINLRILTAALEWGSQTVWASE 84

  Fly   284 IVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATD 348
            :.|.  :|...|:|...:||.:..||.:.||..::..|:|||||.|...:|..::...||.|.|.
pombe    85 VSYG--DERIVLQFPSTVPANSVAVLTLPFTARISSGMEGFYRSSYVDSDGNTKYLATTQMEPTS 147

  Fly   349 ARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLVAVVV 413
            |||.||||||||:||||.|.:...::...||||..: |:::.|||:..||..|..|||||:|.:|
pombe   148 ARRAFPCWDEPALKATFTIDITAKENYTILSNMNAV-EETVKDGLKTARFAETCRMSTYLLAWIV 211

  Fly   414 GEYDYVE----GKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAIS 474
            .|.:|||    ||....:.|||:|..|..|||.||.|:..|.|.::...|...|||||.|::||.
pombe   212 AELEYVEYFTPGKHCPRLPVRVYTTPGFSEQGKFAAELGAKTLDFFSGVFGEPYPLPKCDMVAIP 276

  Fly   475 DFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEG 539
            ||.|||||||||||||...:||...:.:.:.:: :|..|.||:|||||||||||::|..||||||
pombe   277 DFEAGAMENWGLVTYRLAAILVSEDSAATVIER-VAEVVQHELAHQWFGNLVTMQFWDGLWLNEG 340

  Fly   540 YASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKG 604
            :|:::.:...:|.:||:.:|..:|||....||.||:|::|||||||:.|..||::|||.|||:||
pombe   341 FATWMSWFSCNHFYPEWKVWESYVTDNLQSALSLDALRSSHPIEVPIMHDYEINQIFDAISYSKG 405

  Fly   605 ASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSKNVSDVMTSWTQHKGFPVV 669
            :.||||:..|:|||||.||:..|:::|:||||.||||||||...|.:::|..|.:||:..|:||:
pombe   406 SCVIRMVSKYVGEDTFIKGIQKYISKHRYGNTVTEDLWAALSAESGQDISSTMHNWTKKTGYPVL 470

  Fly   670 SVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVSTSKNPTGIA--KTFLLDKSSMEVT 732
            ||  .:|:..:.|:...:...|.|....::..::..|:.:.|.|:...:.  |..|.|:|. ::.
pombe   471 SV--SETNDGELLIEQHRFLSTGDVKPEEDTVIYWAPLKLKTMKDGKAVVDEKAVLSDRSK-KIK 532

  Fly   733 LDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMP-AVEKME-LPPLDRLGLIDDMFAMVQAGHAS 795
            :|....:.: |:|....|.||..||.:.|::|.. ||||.: |...||.|||.|:.::.:||:..
pombe   533 VDKEALESY-KLNSEQSGIYRVNYSADHLKKLSQIAVEKPDYLSVEDRAGLIADVASLSRAGYGK 596

  Fly   796 TADVLALVDSYRNETNYTVWTAITNSLTNLH--ILISHTDLMEDFHRFGRNLYEPVAYRLGWEPR 858
            .:..|.|:.::::|.|:.|:..:...|..:.  :....:|::....:....:....|:.||||.:
pombe   597 VSSTLDLIKTWKDEPNFVVFAEMLARLNGIKSTLRFESSDIIAAMKKLVLEVSATKAHSLGWEFK 661

  Fly   859 DGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRRHVNGTE-LLPADLRTTCYKAVLQDGDEKI 922
            ..::|:....:|.|......|.....:::|..:|..:.:|.: .:..:||:..:...::.|..|.
pombe   662 ANDDHIIRQFKSTVYNYAGLFGDDKVVKDALSKFDAYASGNKSAINDNLRSAVFNIAIRYGGAKS 726

  Fly   923 FNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSEVRAQDSVFVIVAVAINPKGRD 987
            ::::|::|..|:....::...||.|...|.|.:::.:|..:...|:.||...::|.::.:..|..
pombe   727 WDQLLEIYTKTNDPYVRNSCLRAFGVTEDEKYIQKTLDLTLDPIVKEQDIYLILVTLSTHKNGVL 791

  Fly   988 MAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIPGCERTVSQAVE 1051
            ..|:|...|..:||.|.. .|.:...:::::...|.......:::||.........||.:.|:::
pombe   792 AMWKFATSNWDKLLSRLPVAGTMRGYVVRFVTSGFTHASAIDKIKEFFADKDTKLYERALQQSLD 856

  Fly  1052 TIRLNAAWLQRDREQLAIFLRDDQ 1075
            ||..|::::.:..:.:..:|::::
pombe   857 TISANSSFIDKSLDDITRWLKENR 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	175/388 (45%)
		M1_APN_2	227..667	CDD:189008	204/443 (46%)
		ERAP1_C	742..1052	CDD:288671	72/315 (23%)
ape2	NP_595998.1	PepN	24..871	CDD:223385	297/854 (35%)
		M1_APN_2	27..468	CDD:189008	204/444 (46%)
		ERAP1_C	541..857	CDD:288671	72/316 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	253	1.000	Domainoid score	I392
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36199
Inparanoid	1	1.050	549	1.000	Inparanoid score	I198
OMA	1	1.010	-	-		QHG53945
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		oto100899
orthoMCL	1	0.900	-	-		OOG6_100948
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2032
SonicParanoid	1	1.000	-	-		X67
TreeFam	1	0.960	-	-
	13	12.760