DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and LVRN

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	919	Identity:	275/919 - (29%)
Similarity:	445/919 - (48%)	Gaps:	99/919 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLK-------EFTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFE 275
            |||..:||.||:|.|.|.|:       ...|||:..:.|.....|:::.|::|....:..|:...
Human    97 RLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGP 161

  Fly   276 CS---------KLKPEKIVYSAENETATLEFAQEIPAETQGVLHMSFTGELNDKMK-GFYRSKYF 330
            .|         ::..:.:.::.:.|...||.::.:...:...|.:||:|.:.:.:: |.:.:.|
Human   162 LSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVY- 225

  Fly   331 GPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVI----KEDSLPD 391
            ...||.|....:|.|.|.||..|||:||||:||||:||::.....|||||||.:    |||....
Human   226 TDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGS 290

  Fly   392 GLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGT--FALEVATKVLPY 454
            ......|..||.|.|||||.|:.:||:| .:::.|..:|::........|:  |||.:...:..:
Human   291 KWTVTTFSTTPHMPTYLVAFVICDYDHV-NRTERGKEIRIWARKDAIANGSADFALNITGPIFSF 354

  Fly   455 YKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAH 519
            .:|.|||:|.|||.|:||:..|...|||||||:.:.|:.:|::||:....:|..|:..|.|||.|
Human   355 LEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGH 419

  Fly   520 QWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEV 584
            |||||||||.||.::|||||:||:.||..:::..|:......|.:::....|..|....:..:.:
Human   420 QWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAM 484

  Fly   585 PVGH--PSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQE 647
            .|.:  .|||.|:||..:|:||||:.|||..::.|..|...:..||....|.|...:|||...|.
Human   485 KVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQM 549

  Fly   648 ASS--------KNVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWV 704
            |..        ..:.::|.|||...||||:::........|....|:..|   :.:....|..|:
Human   550 AIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIK---NRTLLTSNDTWI 611

  Fly   705 VPISVSTSKNPTGIAKTFLLDKSS-----MEVTLDNVDED-DWIKINPGTVGYYRTRYSQEMLEQ 763
            |||  ...||.| ......||:||     |:|:    |.| ||:.:|....||||..|.:...::
Human   612 VPI--LWIKNGT-TQPLVWLDQSSKVFPEMQVS----DSDHDWVILNLNMTGYYRVNYDKLGWKK 669

  Fly   764 LMPAVEK--MELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVW-TAITNSLTNL 825
            |...:||  ..:|.:.||.||||.|::.:..:......|.|......|....|| |.:.|.:|
Human   670 LNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVT-- 732

  Fly   826 HILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLT------RLVSFRS--- 881
            ..|:|..::.:.:....|.|.:.:  .|.|      |...|::|..||.      .|:|...
Human   733 RDLVSEVNIYDIYSLLKRYLLKRL--NLIW------NIYSTIIRENVLALQDDYLALISLEKLFV 789

  Fly   882 -------SDTIEEAKIRFRRHVNGTE-LLPADLR--TTCYKAVLQDGDEKIFNEMLDLYRATDLH 936
                   .|.::.:|..|.:.|:..| .:|..::  ..||...|  |.:|.::.:|:.|..|...
Human   790 TACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIAL--GSDKEWDILLNTYTNTTNK 852

  Fly   937 EEQDRISRALGCCGDLKLLRRVIDFAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQLL 1001
            ||:.:::.|:.|..|..:|.|.:::|:|:.....:...:|..||.:..||.:|.:|...|.:.:.
Human   853 EEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVASSEVGRYVAKDFLVNNWQAVS 917

  Fly  1002 ERYQGGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIPGCER-TVSQAVETIRLN--------- 1056
            :|| |...|..||..:.....::.:..|:::|.. |.:...:| .|...::||:..
Human   918 KRY-GTQSLINLIYTIGRTVTTDLQIVELQQFFS-NMLEEHQRIRVHANLQTIKNENLKNKKLSA 980

  Fly  1057 --AAWLQRD 1063
              ||||:|:
Human   981 RIAAWLRRN 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	141/410 (34%)
		M1_APN_2	227..667	CDD:189008	159/472 (34%)
		ERAP1_C	742..1052	CDD:288671	80/332 (24%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91
		Peptidase_M1	97..506	CDD:279741	141/410 (34%)
		M1_APN_2	105..577	CDD:189008	159/473 (34%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	77/316 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820