DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and Npepps

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	896	Identity:	491/896 - (54%)
Similarity:	627/896 - (69%)	Gaps:	36/896 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 RRAHTQLLSKEQQLEQERKMAQKAKFERLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPT 255
            ||.|:..|:         .|.:|..|||||..|.|.:|.|.|:|:|.:|||.||......|::.|
Mouse    36 RRLHSLGLA---------AMPEKRPFERLPAEVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQAT 91

  Fly   256 TQITLNALDIVLDSV--------ELH---FECSKLKPEKIVYSAENETATLEFAQEIPAETQGVL 309
            .||.:|..||.:.:.        |:|   |.          |..|:|..||.|...:...| |.|
Mouse    92 NQIVMNCADIDIITASYAPEGDEEIHATGFN----------YQNEDEKVTLSFPSTLQTGT-GTL 145

  Fly   310 HMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKD 374
            .:.|.|||||||||||||:|..|.||.|:|.|||||||||||.|||||||||||||||:||||||
Mouse   146 KIDFVGELNDKMKGFYRSRYTTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKD 210

  Fly   375 RVALSNMPVIKEDSLPD--GLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGK 437
            |||||||.||.....||  .|..|:|.|||:|||||||.||||||:||.:|.|||.|||:|||||
Mouse   211 RVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGK 275

  Fly   438 REQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTS 502
            .|||.||||||.|.||:||||||:.|||||:|||||:||:|||||||||||||||.:|:||||:.
Mouse   276 AEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSC 340

  Fly   503 LMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMY 567
            ...:|.:||.||||:||||||||||||||||||||||:||::|:|||.|.|||||||||||:..|
Mouse   341 SSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADY 405

  Fly   568 TRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQ 632
            |||.|||:|.|||||||.||||||:|||||.|||:||||||||||||||:..|:||||:|||:.|
Mouse   406 TRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQ 470

  Fly   633 YGNTCTEDLWAALQEASSKNVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQA 697
            ..|..|||||.:|:.||.|.::.||.:||:..|||::.||:||. ::.|:|:|.|.||.|.|...
Mouse   471 QKNAATEDLWESLESASGKPIAAVMNTWTKQMGFPLIYVEAEQV-EDDRVLKLSQKKFCASGPYG 534

  Fly   698 DENC-LWVVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEML 761
            .|:| .|:|||::|||::|.......|:||..|.|.|.||..|.|:|:|.||||:|||:||..||
Mouse   535 GEDCPQWMVPITISTSEDPNQAKLKILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAML 599

  Fly   762 EQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRNETNYTVWTAITNSLTNLH 826
            |.|:|.:..:.|||:|||||.:|:|::.:||..||.:||.:::::.||.|||||:.::.:|..|.
Mouse   600 ESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILS 664

  Fly   827 ILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIR 891
            .|:||||..|:...|.::::.|:..||||:|:.||.|||.|||.|||.:|.......|:|||:.|
Mouse   665 TLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRR 729

  Fly   892 FRRHVNGTELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLR 956
            |:.||.|.::|.||||:..|..||:.||....:.||.|::..|:.||::||.|.||.....:|::
Mouse   730 FKEHVEGKQILSADLRSPVYLTVLKHGDGATLDIMLKLHKQADMQEEKNRIERVLGATLSPELIQ 794

  Fly   957 RVIDFAMSSEVRAQDSVFVIVAVAINPK-GRDMAWEFFKENNKQLLERYQGGFLLSRLIKYLIEN 1020
            :|:.||:|.|||.||:|.||..||...| ||..||:|.|:|.::|..|||||||:|||||..:|.
Mouse   795 KVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELHNRYQGGFLISRLIKLSVEG 859

  Fly  1021 FASEERAKEVEEFLQVNQIPGCERTVSQAVETIRLNAAWLQRDREQLAIFL 1071
            ||.::.|.||:.|.:.:..|..|||:.|..|.|.||||||:||.:.:..:|
Mouse   860 FAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDADSIHQYL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	256/398 (64%)
		M1_APN_2	227..667	CDD:189008	289/452 (64%)
		ERAP1_C	742..1052	CDD:288671	144/310 (46%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	256/398 (64%)
		M1_APN_2	62..505	CDD:189008	289/453 (64%)
		Substrate binding. /evidence=ECO:0000250	317..321		3/3 (100%)
		ERAP1_C	580..891	CDD:288671	144/310 (46%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847092
Domainoid	1	1.000	352	1.000	Domainoid score	I1008
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36199
Inparanoid	1	1.050	963	1.000	Inparanoid score	I324
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	1	1.010	-	-		QHG53945
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		oto92849
orthoMCL	1	0.900	-	-		OOG6_100948
Panther	1	1.100	-	-	LDO	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2032
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750