DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and Y42A5A.1

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_505820.1	Gene:	Y42A5A.1 / 179536	WormBaseID:	WBGene00012776	Length:	1045	Species:	Caenorhabditis elegans

Alignment Length:	986	Identity:	261/986 - (26%)
Similarity:	398/986 - (40%)	Gaps:	254/986 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 VPR-HYELLLQPNLKEF------------TFTGKTVVQVN-VKEPTTQITLNALDIVLDSVELHF 274
            :|: |..||.:..||.|            .|:.|..|:|: .....::|.|::     ||.:...
Worm   153 IPQIHIPLLYEVELKLFVPWRPTISFGSDNFSVKGHVRVHFTSGGGSRILLHS-----DSKQHIG 212

  Fly   275 ECSKLKPEKIVYSAENETATL-----EFAQ--EIPAETQGVLHMSFTGELNDKMK-------GFY 325
            :|       :|....|...|:     :::|  ::..||..:..|::|.::..|..       |.:
Worm   213 DC-------VVRDELNRNITVKLVGRQYSQILDLNLETDMIHGMNYTLDVAFKSAINLNLAYGLF 270

  Fly   326 RSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKEDSLP 390
            .:.|...| |.|:...||.:.::||..|||.|.|.:||.||..::.|....:::||  ::..:..
Worm   271 AAPYTFEN-ETRYVVATQLQISEARTVFPCIDVPDMKAQFDTVIIHPTGTTSIANM--MENSTKV 332

  Fly   391 DG-LRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPY 454
            || .....|.|||.|||||.|..|.:|.|:|..|..||..||:....|........:....||.:
Worm   333 DGEWTTTTFHRTPPMSTYLFAFSVSDYPYLETFSGRGVRSRVYCDPTKLVDAQLITKSIGPVLDF 397

  Fly   455 YKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAH 519
            |:|||.|.|||.|:|::.:...|..|||||||:|.|:|..|......::.:|..:...|.||:||
Worm   398 YEDYFGIPYPLEKLDVVIVPALSVTAMENWGLITIRQTNGLYTEGRFAISQKHDVQEIVAHELAH 462

  Fly   520 QWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIW--------TQFVTDMYTRALELDSL 576
            |||||||||:||..||||||:|:.:....|.  |.|...|        :|.|.   .||.::||:
Worm   463 QWFGNLVTMKWWNDLWLNEGFATLISVRAVD--FLENTTWRYEDSSAESQCVA---LRADQIDSI 522

  Fly   577 ------KNSHPIEVPVGHPSEIDEIFDE--------ISYNKGASVIRMLHDYIGEDTFRKGMNLY 627
                  |||:               ||.        |.|.|.|.:|||:...:.||.||:|:..:
Worm   523 SPVSGKKNSN---------------FDSYMEIQGKAIIYKKSAIIIRMIERLVEEDIFRQGLKRF 572

  Fly   628 LTRHQYGNTCTEDLWAAL---QEASSK--------NVSDVMTSWTQHKGFPVVSVESEQTSKNQR 681
            |....|.|...|||:..|   .::|:.        ::||||.:|.:...|||:.|..::.|
Worm   573 LNTFLYKNADHEDLFNVLVYVHDSSAGGHLRGQNFSLSDVMDTWIRQAHFPVIHVNRKEGS---- 633

  Fly   682 LLRLKQCKFTADGSQADENCLWVVPISVSTSKNP-TGIAKTFLLDKSSMEVTLDNVDEDDWIKIN 745
            |:.|:|.|:........|..:|.:||...   :| :|..|.|.|..:..:|    .|....:.::
Worm   634 LVTLRQEKYEHVPRDEPEKQVWKIPIFYD---DPVSGKHKVFWLTDTQPKV----FDMGGLLVVD 691

  Fly   746 PGTVGYYRTRYSQEMLEQLMPAV--EKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDSYRN 808
            |..:.|.|.||..||...:..|:  :...:|...|..||||..||.:.|..          :|:.
Worm   692 PHQLTYMRLRYDMEMYSDITMALMDDFTMIPTNSRSRLIDDTLAMAENGQL----------TYKV 746

  Fly   809 ETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNL--YEPVAY-RLGWE------------PR 858
            ..|.|::             :|.......|..|...|  :.|..| ..||.            |.
Worm   747 PFNLTMY-------------MSREIAYRPFQTFSAYLDFFLPRMYIHEGWSIYKKYLELVVGIPF 798

  Fly   859 DGEN---------HLDTLL--RSLVLTRLVSFRSSDTIEEAKIRF----------RRHVNGTEL- 901
            |..|         |...|.  |.:|:.|.........:..||.||          .:.::|.|.
Worm   799 DKFNAEGLDVSFDHNTDLFHTRQIVVFRACGIEYEPCVRMAKQRFAELRVNCSGENQLLSGMECN 863

  Fly   902 -LPADLRTTCYKAVLQDGDEKIFN-----EMLDLYR-----------ATDLHEEQDR-------- 941
             :|..||...|.|.:.||.::.|:     .|::.|.           .|::.|..||
Worm   864 KIPYYLRPHVYSAAINDGTQEDFDFLYKKWMIEHYMMEHDNIFTGLCTTNIRENSDRAWRQVIKN 928

  Fly   942 ------ISRALGCCGDLKLLRRVIDFAMSSEVRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQL 1000
                  :.||..|...|.....::|...      :|.|::              .||..::.|.|
Worm   929 GARENVMVRAQLCSKKLSKNNFILDLLY------EDKVYL--------------KEFVDKDRKSL 973

  Fly  1001 LERYQGGFLLSRLIKYLIENFASEERAKEVEE----FLQVNQIP----------GCERTV----- 1046
            ....|   ||.|.|.|       ||...:.:|    :.|:..||          ...:||
Worm   974 FALQQ---LLYRKINY-------EEEVLKADEVFKPYPQLRWIPKLRAIASDRLDWRKTVAAQFT 1028

  Fly  1047 ---SQAVETIR 1054
               |:|:|.:|
Worm  1029 GNASEAIEEMR 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	133/430 (31%)
		M1_APN_2	227..667	CDD:189008	155/500 (31%)
		ERAP1_C	742..1052	CDD:288671	83/401 (21%)
Y42A5A.1	NP_505820.1	Peptidase_M1	159..549	CDD:279741	131/424 (31%)
		M1_APN_2	181..623	CDD:189008	149/476 (31%)
		ERAP1_C	688..998	CDD:288671	76/362 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820