DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and Y67D8C.9

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001122826.1	Gene:	Y67D8C.9 / 177088	WormBaseID:	WBGene00022073	Length:	1144	Species:	Caenorhabditis elegans

Alignment Length:	1090	Identity:	245/1090 - (22%)
Similarity:	402/1090 - (36%)	Gaps:	307/1090 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 HTSADVIPGQDRHHPGCNYQQIRRAHTQLL---------SKEQ----------QLEQER------ 208
            :|::...|....||           ||.||         ||::          .||::|
Worm    96 YTTSTATPESLSHH-----------HTHLLTTSSAALGQSKKKTPPRVVERLIPLEKKRNFTISD 149

  Fly   209 ----------------------KMAQKAKFERLPTNVVPRHYELLLQPNLKEFT-FTGKTVVQVN 250
                                  |::..|....||..::|.||:|.|     :|: |.....::.|
Worm   150 VFPPPADGGFGIAEQLHAVRANKLSTDALLVPLPLYILPYHYDLQL-----DFSQFDTHLFIRAN 209

  Fly   251 VKEPTTQITLNAL-DIVLDSVELH------FECSKLKPEKIVYSAENETATLEFAQEIPAETQGV 308
            :     .|.|.:. :...|.::.|      .|..:|:.:...:.|:.      |.:|   |::.:
Worm   210 I-----SIHLESYGNSTEDEIQFHLGPNIKMERMRLRKDGKKFYAKT------FKRE---ESKKL 260

  Fly   309 LHMSFTGELNDKMKGFY--RSKYFGPNGEERFAGV------------------TQFEATDARRCF 353
            ..:|....|   .||.|  ...|.....:|...||                  |:||.|.||..|
Worm   261 GRISLRDPL---QKGKYILEMTYNMTICDEDVDGVRCSLDNQTNSSLKATSFTTKFEPTLARAFF 322

  Fly   354 PCWDEPAIKATFDITLVVPKDRVALSNMPVIK---EDSLPDGLRRVRFDRTPIMSTYLVAVVVGE 415
            ||||||.:||||:|::...|....|||||.::   ..|..|..:...|..||.|||||:|..:||
Worm   323 PCWDEPGVKATFNISVRHNKKYTVLSNMPPVESHDHKSWEDQFKTTVFQTTPPMSTYLLAFAIGE 387

  Fly   416 YDYVEGKSDDGVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGA 480
            :..:|.:::.|:.|.|:|.........|.||.|..:....:|...|.|||||:||||..:|..|.
Worm   388 FVKLESRTERGIPVTVWTYPEDVMSMKFTLEYAPVIFDRLEDALEIPYPLPKVDLIAARNFHVGG 452

  Fly   481 MENWGLVTYRETFVLVDPKNTS--------LMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLN 537
            |||||||.:....:...|..|.        :..:..|...:.||.|||||||||||..|:.|:||
Worm   453 MENWGLVVFEFASIAYTPPITDHVNETVDRMYNEFRIGKLIAHEAAHQWFGNLVTMRDWSELFLN 517

  Fly   538 EGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEV--PVGHPSEIDEIFDEIS 600
            ||:|:|..:   ..:..|..:..||.......:|.|...:..|.:.:  .:...|:::..|...:
Worm   518 EGFATFYVY---EMMSTERPVTAQFEYYDSLASLILAQSEEDHRLSLVRELATESQVESSFHPTN 579

  Fly   601 -YNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAAL-----QEASSKNVSDVMTS 659
             |.||..:||||.|.:.:..|:..:..||.::.|.:...:||:|:|     ..|..:.:|.|:..
Worm   580 LYTKGCVLIRMLRDLVSDFDFKAAVRRYLRKNAYRSVSRDDLFASLPAYADHGAEQEKLSHVLEG 644

  Fly   660 WTQHKGFPVVSV----ESEQTSKNQR------------------LLRLKQCKFTADG-------- 694
            |..::|.|.:::    ::|..:.:||                  .:|.:..:...||
Worm   645 WFVNEGIPEITLIRNYDNEMMTISQRKTVHHEYRSFLKDRKASASVRYRGSRSAEDGSTLFDDAL 709

  Fly   695 -------------------------------SQADE----------NCLWVVPI-----SVSTSK 713
                                           |:.||          ..||.:||     |:.||:
Worm   710 FDGYIEKKKDRRRKHRPIRRKTSTPPSISPISRRDELRKPRRVGASQDLWTIPITYMFGSLKTSE 774

  Fly   714 NPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEK--MELPPL 776
            ..  :.:.|.|...::......:..:..:.:||.....||..|.....:.|...:.:  :|:...
Worm   775 GQ--VIREFWLKNRTVSFGDAEISPNQAVLVNPEWKYPYRVNYDLLNWKLLARTLHQNHLEINEK 837

  Fly   777 DRLGLIDD--------------MFAMVQAGHASTADVL--------ALVDSYRNETNYTVWTAIT 819
            .|:.||.|              ::.:....|.:..:|:        ..:|.|:
Worm   838 SRMQLILDAEYFLSNSVNPHLYLYLLGYLAHETKMEVMLFGIDAVYKFIDVYK------------ 890

  Fly   820 NSLTNLHILISHTDLMEDFHRFGRNLYEPVA----YRLGWEPRDGENHLDTLLRSLVLTRLVSFR 880
            .:..|..||:               .:|||.    :.|.....|.|.....|:|...|.:|...|
Worm   891 ATQLNKAILV---------------YFEPVISQMDHLLNESQVDAETASLWLVRPERLAKLYQMR 940

  Fly   881 SSDTIEEAKIRF------RRHVNGTELLPADLRTTCYKAVLQDGDE-KIFNEMLDLYRATDLHEE 938
            .:..:...|..:      |.....||.:...:...|::......|| |...::|| .|......:
Worm   941 CAAGLSSCKNDYYTQRWSRSPDEWTEDVHKQVTAVCHQLFTNTPDEVKTVQDLLD-SRLQSSGAK 1004

  Fly   939 QDRISRALGCCGDLKLLRRVIDFAMSSE-----VRAQDSVFVIVAVAINPKGRDMAW-------- 990
            .....:...|..|.|||||.....:|::     ..|..|.|   ::..||..|...|
Worm  1005 WALTVQLAACSHDQKLLRRTARAIVSTKNAVVYASALQSDF---SLHYNPTFRKYLWAEIAKMST 1066

  Fly   991 ----EFFKENNKQLLERYQGGFLLSRLIKYLIENFASEERAKEVEEFLQV 1036
                ..|..|:..:|.       .||::.:.:         |.::|..|:
Worm  1067 FEKTALFSTNSTDILP-------ASRILLHSV---------KTIDELQQI 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	128/427 (30%)
		M1_APN_2	227..667	CDD:189008	145/486 (30%)
		ERAP1_C	742..1052	CDD:288671	63/347 (18%)
Y67D8C.9	NP_001122826.1	Peptidase_M1	182..584	CDD:279741	128/426 (30%)
Y67D8C.9	NP_001122826.1	M1_APN_2	190..652	CDD:189008	145/486 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870