DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psa and T16G12.1

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_499230.2	Gene:	T16G12.1 / 176416	WormBaseID:	WBGene00011803	Length:	1890	Species:	Caenorhabditis elegans

Alignment Length:	928	Identity:	226/928 - (24%)
Similarity:	405/928 - (43%)	Gaps:	126/928 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 KAKFERLPT-NVVPRHYELLLQPNL---------KEFTFTGKTVVQVNVKEPTTQITLNALDIVL 267
            |..:|:.|. :.|..:|:|.||.|:         :..||:..:.|...:..||:.||:||..::.
Worm   989 KTPWEKTPNIDAVFPYYKLDLQVNIPGSGPYQWYENMTFSATSTVTFQLVSPTSSITINAHRLMF 1053

  Fly   268 DSVELHFECSKLKPEKIVYSAENETA----TLEFAQ----------EIPAETQGVLH-------M 311
            |.|.:.           :|:..:|.|    .::|::          .||.....||:       :
Worm  1054 DPVSIR-----------LYNENDENAHTPIPIDFSKVMKDYDKGTVTIPTMNNTVLYPNQYSLFI 1107

  Fly   312 SFTGEL-NDKMKGFYRSKYFGP-NGEERFAGVTQFE-ATDARRCFPCWDEPAIKATFDITLVVPK 373
            .:||.: .:..:|...:.|.|. |..:.:...|.|| ...||...||||||:.|..|::::..|.
Worm  1108 EYTGFIFQNPDEGDASNTYLGGLNNRKGWIFTTDFEGGPGARSLLPCWDEPSYKGQFEVSVFHPT 1172

  Fly   374 DRVALSNMPVIKEDSLPDGLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKR 438
            |.:||||...|:.....:|....:|..|..|||||:|:.||.:..:...:..|||.||:|..|..
Worm  1173 DMIALSNEVDIQRTIYDNGWTTTKFATTNQMSTYLLALCVGHFSNLATVTRTGVLTRVWTWSGME 1237

  Fly   439 EQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDF--SAGAMENWGLVTYRETFVLVDPKNT 501
            :.|.|||.|....:.:.::||:..:||.|:|::|:.::  :|||||||||:....:..:.||...
Worm  1238 QYGEFALNVTAGTIDFMENYFSYDFPLKKLDVMALPEYTMNAGAMENWGLIIGEYSLFMFDPDYA 1302

  Fly   502 SLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDM 566
            :......:|.|..||:.|||||::||::||..::||||:|.:.....:.:.|||...::......
Worm  1303 TTRDITEVAETTAHEVVHQWFGDIVTLDWWNDIFLNEGFAQYWFANGIDNTFPEQHAYSIDYNRF 1367

  Fly   567 YTR--ALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLT 629
            |..  ||:.|.:..   :..||  .|:...:|....|.||::::.:|::.:....|::|::.|||
Worm  1368 YMNHIALKYDCIPG---VAKPV--ISDTPPVFGIEPYYKGSALLNLLNNVLTPAVFQEGLSSYLT 1427

  Fly   630 RHQYGNTCTEDLWAALQEASSK-----------NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLL 683
            ::.|.|....:||.:|..|:.:           :||..|..:|....:|::::....||..|  .
Worm  1428 QYGYVNASPRNLWTSLTVAAQRHNITDWNGQPLDVSSFMDPYTLQTSYPIITLTLRGTSTVQ--A 1490

  Fly   684 RLKQCKFTADGSQADENCLWVVPISVSTS--------KNPTGIAKTFLLDKSSMEVTLDNVDEDD 740
            ..:.|       .:||. ||.||:...|.        .|.||......|........:||.....
Worm  1491 NQQSC-------MSDET-LWNVPLFTQTPGALDFNWFVNFTGGNDATWLRPLPTGYRVDNAGSTS 1547

  Fly   741 WIKINPGTVGYYRTRYSQEMLEQLMPAVEKMELPPLDRLGLIDDMFAMVQAGHASTADVLALVDS 805
            :.:||.....:|      .:..||:..:..|.  ...|..|:||.....|:|.......|.|...
Worm  1548 FARINYDDKSWY------SIQAQLLSNMNTMS--STTRAMLLDDANFFYQSGRWEMTKFLDLTLY 1604

  Fly   806 YRNETNYTVWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHL---DTL 867
            ..||.:...|.......|.:.....:...::....:...:.:....:..|    ..|.|   |.:
Worm  1605 LVNEDSLAPWEQAIEFFTEMLNRFQYQPEIDTVRNYVIQITKNAVSKFQW----NTNGLWANDRI 1665

  Fly   868 LRSLV-LTRLVSFRSSDTI-----EEAKIRFRRHVNGT---ELLPADLR--TTCYKAVLQDGDEK 921
            ::.|| :..|...|.|..:     ....::.:..::||   ..:..:||  |.|| .:.|..:..
Worm  1666 VQLLVNVNNLAVNRQSRQVALTLFNNFVLKCKYSLSGTGKCSGIHPNLRQPTYCY-GLRQSNNID 1729

  Fly   922 IFNEMLDLY-----RATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSEVRAQDSVFVIVAVAI 981
            .|..:.:||     .|..|..:...:..||||..:|.|.:.::...:|.:....    ::.::|:
Worm  1730 DFTTVNNLYSWFVQNAGYLQTDGSNLLNALGCVQNLDLQKTMLRSILSGDYPPS----LLNSIAV 1790

  Fly   982 NPKGRDMAWEFFKENNKQLLERYQGGFLLSRLIKYLIENFASE---ERAKEVEEFLQVNQIPGCE 1043
            :....|:.:.|..:|.:.:|   ...|..|..:|.:.:|:::.   |.||:.:.....|.:...:
Worm  1791 HDDSSDVLYNFLLDNTQDIL---NAPFDFSLYVKAMFQNWSTSNQLELAKDFQNSSNYNLLNAAQ 1852

  Fly  1044 RTV-SQAVETIRLNAAWL 1060
            :.: .|.:.|:..||.|:
Worm  1853 KNIYKQGILTVNSNANWM 1870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	123/423 (29%)
		M1_APN_2	227..667	CDD:189008	139/487 (29%)
		ERAP1_C	742..1052	CDD:288671	61/332 (18%)
T16G12.1	NP_499230.2	M1_APN_2	88..549	CDD:189008
		ERAP1_C	640..931	CDD:314669
		Peptidase_M1	999..1402	CDD:279741	122/418 (29%)
		ERAP1_C	1542..1839	CDD:314669	60/316 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820