DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psa and mnp-1

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_497878.1	Gene:	mnp-1 / 175564	WormBaseID:	WBGene00007139	Length:	781	Species:	Caenorhabditis elegans

Alignment Length:	674	Identity:	132/674 - (19%)
Similarity:	243/674 - (36%)	Gaps:	164/674 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 LLSKEQQLEQERKMAQKAKFERLPTNVVPRHYELLLQPNLKEFTFTGKTVVQVNVKEPT----TQ 257
            |..|.:..|...|.|:   .:.||.:..|....|...|:..:.......:...:|::|.    .|
Worm   138 LKDKTKDFEIVEKCAE---IQALPVSCTPSQSPLTSDPSKFQPIHYVLNITIRDVRKPVLEGHMQ 199

  Fly   258 ITLNALD----IVLDSVELH----------FECSKLKPEKIVYSAE---NETATLEFAQEIPAET 305
            :..:..|    |.|.||::|          ..|:  ..|.|..|..   ::...||.||.|   :
Worm   200 LFASTKDQVQAISLHSVKIHNLENRDRIHVVNCN--TGETICVSRVHQIDDLIHLELAQSI---S 259

  Fly   306 QGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGV---------TQFEATDARRCFPCWDEPAI 361
            .||       .|...:.||. |...||:..::....         :.||.|.||..||.:|....
Worm   260 SGV-------NLRVDIDGFI-SADSGPHVFKQIPTAKWRVPQMIGSVFEPTSARHVFPSFDLHNQ 316

  Fly   362 KATFDITLVVPKDRVALSN------------------MPVIKEDSLPDGLRRVRFDRT-PIM--S 405
            |:||::.|.......|::|                  :|:|.:.     |..|.|::| |:.  :
Worm   317 KSTFNLCLNHGPSMSAIANSLINPNVSTSGISCFEKTVPLIAQQ-----LSFVAFEKTNPLFYNT 376

  Fly   406 TYLVAVVVGEYDYVEGKSDDGVLVRVFTPVGKR-EQGTFALEVATKVLPYYKDYFNIAYPLPKMD 469
            |.:....:.|.|            .:|....|. :|..:.....:||:.....:...:|||.:::
Worm   377 TTMDGAYLPEID------------MIFNLNAKNFKQYEWIHSEVSKVMALMSKWSGFSYPLTRLE 429

  Fly   470 LIAISDFSAG--AMENWGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWT 532
            :: ::...||  |:   |::|.....:... |:||...      |:..|:..||...:||.|
Worm   430 IV-VAPVQAGHSAL---GVITLPAQAIAYQ-KHTSTHE------TLIKEVIGQWMEGVVTTE--- 480

  Fly   533 HLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFD 597
            |....:...::||             |.  :.:      ||..:|.:..:||....|..::|..|
Worm   481 HTCFEKALIAYVE-------------WK--INE------ELQIVKKTRKMEVSKIRPRNLNETAD 524

  Fly   598 EI---------SYN----KGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEAS 649
            .:         |.|    :...|...|.:..|::|....:.:...:..: :|.|...||:..|.:
Worm   525 SVRVLRQIKSQSSNLCSPRFVEVFYTLDETYGQETVIGMIRVIFDKFAF-STATISDWASAAETA 588

  Fly   650 S---KNVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVST 711
            :   .....::..|.:           ..::.::.:||......:.:.:|..|. .|.||:.:|
Worm   589 TGGRPEAGALIHQWYR-----------PSSTISRPVLRAVVSSNSVEFNQLTEE-TWTVPLEIS- 640

  Fly   712 SKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVEKMELPPL 776
                 |.|.|.|...|..:..:..| ..|::.::.|...:....|..:...:|:........|..
Worm   641 -----GSAGTQLAVISEKKQAIPFV-SSDYVVVDAGRKSHAFVVYDADTYLRLIRCFGDSRCPSK 699

  Fly   777 DRLGLIDDMFAMVQAGHASTADVL 800
            :..|:..|:      |.|..|::|
Worm   700 EIGGIFSDL------GAALLANIL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	92/452 (20%)
		M1_APN_2	227..667	CDD:189008	99/509 (19%)
		ERAP1_C	742..1052	CDD:288671	10/59 (17%)
mnp-1	NP_497878.1	Peptidase_M1	172..556	CDD:279741	90/448 (20%)
		GluZincin	<294..>480	CDD:301352	46/213 (22%)
		GluZincin	<547..602	CDD:301352	9/55 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810