DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and Lnpep

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	943	Identity:	304/943 - (32%)
Similarity:	468/943 - (49%)	Gaps:	103/943 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 PGCNYQQIRRAHTQLLSKE--QQLEQERKMAQKAKFERLPTNVVPRHYELLLQPNLKEFTFTGKT 245
            |.|.:.: ...|....|.|  |.:....|:...|:. ||||.::|:.|||.|.|||...||.|..
  Rat   132 PRCTFTK-EGCHKTNQSAELIQPIATNGKVFPWAQI-RLPTAIIPQRYELSLHPNLTSMTFRGSV 194

  Fly   246 VVQVNVKEPTTQITLNALDIVLDSVEL------------------HFECSKLKPEKIVYSAENET 292
            .:.:...:.|..|.|::....:.||..                  |.:.:.:.||.:: :..|.|
  Rat   195 TISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLL-TGHNYT 258

  Fly   293 ATLEFAQEIPAETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRCFPCWD 357
            ..:|::..|                ::...|||...|...:.|::....||||...||..|||:|
  Rat   259 LKIEYSANI----------------SNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFPCFD 307

  Fly   358 EPAIKATFDITLVVPKDRVALSNMPVIKEDSLP--DGLRRVRFDRTPIMSTYLVAVVVGEYDYVE 420
            |||.||||.|.:...:...||||||  |:.|:|  :||.:..|..:..|||||||.:|||   :.
  Rat   308 EPAFKATFIIKITRDEHHTALSNMP--KKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGE---MR 367

  Fly   421 GKSDD--GVLVRVFTPVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMEN 483
            ..|.|  |.||.|:....|.:|...||:...|:|.:|::||.|.|||.|:||:||.||.||||||
  Rat   368 NLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMEN 432

  Fly   484 WGLVTYRETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLC 548
            |||:|:||..:|.|...:|:..::.:...:.||:|||||||||||:||..||||||:|:|:|:..
  Rat   433 WGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFS 497

  Fly   549 VHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRMLHD 613
            |..:|.|.:.:..|: |...:.:..|||.:||||...|....:|:|:||.:||.||||::.||..
  Rat   498 VEKIFKELNSYEDFL-DARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKS 561

  Fly   614 YIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQEASSK--NVSDVMTSWTQHKGFPVVSVESEQT 676
            |:.||.|:..:.|||..|.|....::|||.:..|.:.|  :|..:|.:||..||||:|:|:.:.|
  Rat   562 YLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRKGT 626

  Fly   677 SKNQRLLRLKQCKF----TADGSQADENCLWVVPIS-VSTSKNPTGIAKTFLLDKSSMEVTLDNV 736
            .     |.|:|.:|    ..:...:|.:.||.:||| |:..:|.:......||||.|..:.|  .
  Rat   627 E-----LLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINL--T 684

  Fly   737 DEDDWIKINPGTVGYYRTRYSQE----MLEQLM--PAVEKMELPPLDRLGLIDDMFAMVQAGHAS 795
            ::..|:|:|....|||...|:.:    ::.||.  |.|    |...||..||:::|.:...|...
  Rat   685 EQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYV----LSDKDRANLINNIFELAGLGKVP 745

  Fly   796 TADVLALVDSYRNETNYTVWTAI---TNSLTNLHILISHTD----LMEDFHRFGRNLYEPVAYRL 853
            ......|:|..||||:....|..   |:.:.||...:.|.|    |:...|:..:|..:...:..
  Rat   746 LQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTD 810

  Fly   854 GWEPRDGENHLDTLLRSLVLTRLVSFRSSDTIEEAKIRFRR------HVNGTELLPADLRTTCYK 912
            ...|...|      |||    .|:.|..:.::|.......:      ..|||:.||.|:.||.:|
  Rat   811 EGTPSMRE------LRS----ALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFK 865

  Fly   913 AVLQDGDEKIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSE-VRAQDSVFVI 976
            ...:  .||.:..:..:|.:.....|:|:|..||....|...|..::..::..: :|.|....:|
  Rat   866 VGAR--TEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQKLSLII 928

  Fly   977 VAVAINPKGRDMAWEFFKENNKQLLERYQ-GGFLLSRLIKYLIENFASEERAKEVEEFLQVNQIP 1040
            ..|.....|..:||:|.|||..:|:.::. |.:.:..::......|:::....||:||.: ||..
  Rat   929 RTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFFE-NQSE 992

  Fly  1041 GC--ERTVSQAVETIRLNAAWLQRDREQLAIFL 1071
            ..  .|.|.:|.|.|.||..|:.|:.:.|.::|
  Rat   993 ATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	156/407 (38%)
		M1_APN_2	227..667	CDD:189008	177/463 (38%)
		ERAP1_C	742..1052	CDD:288671	82/332 (25%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	156/407 (38%)
		M1_APN_2	176..617	CDD:189008	177/463 (38%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	690..1005	CDD:288671	82/331 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53945
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830