DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Psa and Anpep

DIOPT Version :9

Sequence 1:NP_728614.1 Gene:Psa / 38175 FlyBaseID:FBgn0261243 Length:1075 Species:Drosophila melanogaster
Sequence 2:NP_032512.2 Gene:Anpep / 16790 MGIID:5000466 Length:966 Species:Mus musculus


Alignment Length:984 Identity:299/984 - (30%)
Similarity:477/984 - (48%) Gaps:132/984 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 SSDAPLLGDLCSQYRAILAHTSADVIPGQDRHHPGCNYQQIRRAHTQLLSKEQQLEQERKMAQKA 214
            |:.||.|....|.       |:|...|..|...|...|                           
Mouse    44 SATAPTLPGSTSA-------TTATTTPAVDESKPWNQY--------------------------- 74

  Fly   215 KFERLPTNVVPRHYELLLQPNLKE-----FTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHF 274
               |||..::|..|.::|:|.|..     :.|.|.:.|:....: ||.:      |::.|.:|::
Mouse    75 ---RLPKTLIPDSYRVILRPYLTPNNQGLYIFQGNSTVRFTCNQ-TTDV------IIIHSKKLNY 129

  Fly   275 ECSKLKPEKIVY-------SAEN--ETATLEFAQEIPAETQGVL--------HMSFTGELNDKMK 322
               .||....|.       .|.|  :|..:|..:.:....||.|        ...|.|||.|.:.
Mouse   130 ---TLKGNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLA 191

  Fly   323 GFYRSKYFGPNGE-ERFAGVTQFEATDARRCFPCWDEPAIKATFDITLVVPKDRVALSNMPVIKE 386
            |||||:|.  .|: ::....||.:|.|||:.|||:||||:||.|:|||:.|.:.:|||||  :.:
Mouse   192 GFYRSEYM--EGDVKKVVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNM--LPK 252

  Fly   387 DSLP----DGLRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDGVLVRVFT-PVGKRE-QGTFAL 445
            :|.|    .......|..||.|||||:|.:|.|:..:...|.:||.:.::. |....| ||.:||
Mouse   253 ESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYAL 317

  Fly   446 EVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTYRETFVLVDPKNTSLMRKQSIA 510
            .|...:|.::..::|.:|||||.|.||:.||:||||||||||||||:.::.|.:::|:..|:.:.
Mouse   318 NVTGPILNFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVV 382

  Fly   511 LTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEFLCVHHLFPEYDIWTQFVTDMYTRALELDS 575
            ..:.||:||||||||||:.||..||||||:||:||:|...:..|.:::....|.:...|.:.:|:
Mouse   383 TVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDA 447

  Fly   576 LKNSHPIEVP---VGHPSEIDEIFDEISYNKGASVIRMLHDYIGEDTFRKGMNLYLTRHQYGNTC 637
            |.:|||:..|   :..|.:|.|:||.|:|:|||||||||..::.||.|:||::.||..:||.||.
Mouse   448 LASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTV 512

  Fly   638 TEDLWAALQEASSK--------NVSDVMTSWTQHKGFPVVSVESEQTSKNQRLLRLKQCKFTADG 694
            ..|||..||:|.::        .|..:|..|....||||::|       |.....:.|..|..|.
Mouse   513 YLDLWEHLQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITV-------NTNTGEISQKHFLLDS 570

  Fly   695 SQ-----ADENCLWVVPISVSTSKNPTGIAKTFLLDKSSMEVTLDNVDEDDWIKINPGTVGYYRT 754
            ..     ::.|.:|:.||....|    |....:.||....:........::||.:|....|||..
Mouse   571 KSNVTRPSEFNYIWIAPIPFLKS----GQEDHYWLDVEKNQSAKFQTSSNEWILLNINVTGYYLV 631

  Fly   755 RYSQEMLEQLMPAVEK--MELPPLDRLGLIDDMFAMVQAG----HASTADVLALVDSYRNETNYT 813
            .|.:...::|...::.  ..:|.::|..:|.|.|.:..|.    ..:..:.|.||    .|..|.
Mouse   632 NYDENNWKKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLV----KEAEYM 692

  Fly   814 VWTAITNSLTNLHILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRDGENHLDTLLRSLVLTRLVS 878
            .|.|..:||....::...:::.....|:.:....|:.:.......:..|...||:........:|
Mouse   693 PWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPPTLMEQYNEINAIS 757

  Fly   879 FRSS-------DTIEEAKIRFRRHVNGTELLPADLRTTCYKAVLQDGDEKIFNEMLDLYRATDLH 936
            ...|       |.:.|...::.::.|...:.| :||:|.|...:..|.|:.:|...:.:|...|.
Mouse   758 TACSSGLKECRDLVVELYSQWMKNPNNNTIHP-NLRSTVYCNAIAFGGEEEWNFAWEQFRNATLV 821

  Fly   937 EEQDRISRALGCCGDLKLLRRVIDFAMSSE-VRAQDSVFVIVAVAINPKGRDMAWEFFKENNKQL 1000
            .|.|::..||.|..|:.:|.|.:.:.::.: :|.||:...|:::|.|..|..:.|:|.:.|.|:|
Mouse   822 NEADKLRSALACSKDVWILNRYLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKL 886

  Fly  1001 LERYQGG-FLLSRLIKYLIENFASEERAKEVEEFLQVNQIPGC---ERTVSQAVETIRLNAAWLQ 1061
            .|.|.|| |..:.||:.:...|:||...:::|:|...|...|.   .|.:.||:|..|.|..|::
Mouse   887 FENYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVK 951

  Fly  1062 RDREQLAIF 1070
            .:::  |:|
Mouse   952 ENKD--AVF 958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PsaNP_728614.1 Peptidase_M1 218..604 CDD:279741 156/417 (37%)
M1_APN_2 227..667 CDD:189008 182/479 (38%)
ERAP1_C 742..1052 CDD:288671 79/327 (24%)
AnpepNP_032512.2 Cytosolic Ser/Thr-rich junction 33..68 9/30 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..64 7/26 (27%)
Metalloprotease 69..966 290/952 (30%)
M1_APN-Q_like 84..545 CDD:341064 181/474 (38%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P15144 351..355 3/3 (100%)
ERAP1_C 618..945 CDD:403137 81/331 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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