DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psa and lvrn

DIOPT Version :9

Sequence 1:	NP_728614.1	Gene:	Psa / 38175	FlyBaseID:	FBgn0261243	Length:	1075	Species:	Drosophila melanogaster
Sequence 2:	XP_031748993.1	Gene:	lvrn / 100496094	XenbaseID:	XB-GENE-980447	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	962	Identity:	264/962 - (27%)
Similarity:	446/962 - (46%)	Gaps:	152/962 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 RLPTNVVPRHYELLLQPNLKE-----FTFTGKTVVQVNVKEPTTQITLNALDIVLDSVELHFECS 277
            |||.|:||.||:|.|.|.::|     :.|:|:..:.::..|.|..:.|:::.:....|.|..
Frog    71 RLPHNLVPLHYDLELWPRMEEDEEGNYPFSGQVNITISCVEDTDVVLLHSIQLNFSDVGLRL--- 132

  Fly   278 KLKPEKIVYSA----------------------------------------ENETATLEFAQEIP 302
             |..:.|:|.:                                        ::....||..:.:.
Frog   133 -LGNKTIMYQSMEKDGKHNALQEGRAYKRLQDPTYDIHGGNVSINNVWTFEDHSYVVLELNERLV 196

  Fly   303 AETQGVLHMSFTGELNDKMKGFYRSKYFGPNGEERFAGVTQFEATDARRCFPCWDEPAIKATFDI 367
            |....:|.:::||.:......|.  .::.....::....:..|...||..:||:||||:||||.|
Frog   197 AGNLYLLELNYTGFIRQNTALFI--THYKDFNIDKAVVASLLEPEYARAVYPCFDEPALKATFKI 259

  Fly   368 TLVVPKDRVALSNMPVI----KEDSLPDG--LRRVRFDRTPIMSTYLVAVVVGEYDYVEGKSDDG 426
            .||.....|||||||.:    :||.  ||  .....||.||.||||:.|.|:.::||| ..::.|
Frog   260 RLVHNSSYVALSNMPAVAVSEREDI--DGSIWTVTTFDTTPKMSTYITAFVICDFDYV-NITERG 321

  Fly   427 VLVRVFT--PVGKREQGTFALEVATKVLPYYKDYFNIAYPLPKMDLIAISDFSAGAMENWGLVTY 489
            ..:||:.  .|.::...:.||.:|..:|.|.:|.||::|||.|.|.:|:.|....|||||||:|:
Frog   322 NEIRVWARKEVVQKGFASLALSIAGPLLSYMEDLFNVSYPLQKTDFVALPDLDVEAMENWGLITF 386

  Fly   490 RETFVLVDPKNTSLMRKQSIALTVGHEIAHQWFGNLVTMEWWTHLWLNEGYASFVEF-------- 546
            .|..::.||:..|...|...:|.|.||||||||||||||:|||.||||||:|:::|:
Frog   387 IEEALIYDPRQKSSNSKFRTSLIVSHEIAHQWFGNLVTMKWWTDLWLNEGFATYMEYFGITFLDS 451

  Fly   547 -LCVHHLFPEYDIWTQFVTDMYTRALELDSLKNSHPIEVPVGHPSEIDEIFDEISYNKGASVIRM 610
             |.::.||..:::...|..|:...|..: |:|.....|....|      :|:|.:|:||::::||
Frog   452 KLELNELFTMHNLQPIFERDVGAHAKTV-SMKEEELYEADSSH------MFNEFTYDKGSALVRM 509

  Fly   611 LHDYIGEDTFRKGMNLYLTRHQYGNTCTEDLWAALQ--------EASSKNVSDVMTSWTQHKGFP 667
            |..::.|..|.||::.||....:.|...:|||..||        ......:..:|.|||..:|.|
Frog   510 LSSFLTEKLFIKGISSYLKTFSFSNVDQDDLWNHLQMFIDHQDEVRLPTTLRHIMQSWTWQRGIP 574

  Fly   668 VVSVESEQTSKNQRLLRLKQCKFTADGSQADENCLWVVPISVSTSKNPTGIAKTFLLDKSSMEVT 732
            ::::::......:.|.:..    ..|...:|.|..|:||  |:..||.|.....:|..||.:...
Frog   575 LLTLDTTTGELAEELFKTD----NTDNITSDSNHTWIVP--VTWMKNGTKQISLWLDSKSKVFPV 633

  Fly   733 LDNVDEDDWIKINPGTVGYYRTRYSQEMLEQLMPAVE--KMELPPLDRLGLIDDMFAMVQAGHAS 795
            |... .|:||.:|....|||||.|::|...:|...:|  ...:|.::|:.||:|.|.:.:.|:..
Frog   634 LTTA-ADEWIVLNINVTGYYRTNYNKENWNRLAKQLEANPKVVPTVNRIQLIEDAFILARYGYTD 697

  Fly   796 TADVLALVDSYRNETNYTVWTAITNSLTNL-HILISHTDLMEDFHRFGRNLYEPVAYRLGWEPRD 859
            ....|:|......|....||..:...:|:. :.||::|: ...|.::......|:..|.....|.
Frog   698 HGTALSLTKYLEKEEEINVWYTVLKHVTSSDYPLITYTN-FPLFKKYILKRISPIYQRFANSIRR 761

  Fly   860 G----------ENHLDTLLRSLVLTRLVSFRSSDTIEEAK---IRFRRHVNGTELLPADLRT--T 909
            .          :.|::     |:|....||...|.::.|.   ..:.::.:| .::|..:|.  .
Frog   762 NFDEAADDYFIQVHIE-----LILKTACSFGLQDCLQLAHQLYATWMKNCSG-NVIPESIRNPIC 820

  Fly   910 CYKAVLQDGDE------KIFNEMLDLYRATDLHEEQDRISRALGCCGDLKLLRRVIDFAMSSEVR 968
            || |:...|::      |:.|:..::        |:|.:..||.|..:..||.|.:::::  |:.
Frog   821 CY-AIANGGEKEWEFAWKMVNKSEEI--------ERDLLFYALSCTKEPWLLHRYLEYSL--EMY 874

  Fly   969 AQDSVFVIVAVAINPKGRDMAWEFFKENNKQLLERYQGGFLLSRLIKYLIENFASEERA----KE 1029
            ...:..:.:.|..|..||.:||||.|||.:::.:.: |..........|:..|||:..:    :|
Frog   875 KSSAFTIFLDVIKNEIGRHIAWEFLKENWQRIHDIF-GPRDTVDFYTVLLPTFASKAASDLQFQE 938

  Fly  1030 VEEFLQVNQIPGCERTVSQAVE---------TIRLN---AAWLQRDREQLAI 1069
            ::.|:...........:.:.||         |.::|   ..||||:.::..|
Frog   939 IQLFINTTINENQRERILEQVENKWRKSLGWTSKINDEILTWLQRNADEAEI 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psa	NP_728614.1	Peptidase_M1	218..604	CDD:279741	141/447 (32%)
		M1_APN_2	227..667	CDD:189008	157/509 (31%)
		ERAP1_C	742..1052	CDD:288671	76/346 (22%)
lvrn	XP_031748993.1	M1_APN-Q_like	79..568	CDD:341064	154/504 (31%)
lvrn	XP_031748993.1	ERAP1_C	641..945	CDD:403137	75/322 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010